ENSG00000162998


Homo sapiens

Features
Gene ID: ENSG00000162998
  
Biological name :FRZB
  
Synonyms : frizzled related protein / FRZB / Q92765
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q32.1
Gene start: 182833275
Gene end: 182867162
  
Corresponding Affymetrix probe sets: 203697_at (Human Genome U133 Plus 2.0 Array)   203698_s_at (Human Genome U133 Plus 2.0 Array)   231273_x_at (Human Genome U133 Plus 2.0 Array)   244419_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295113
NCBI entrez gene - 2487     See in Manteia.
OMIM - 605083
RefSeq - NM_001463
RefSeq Peptide - NP_001454
swissprot - D9ZGF6
swissprot - Q92765
Ensembl - ENSG00000162998
  
Related genetic diseases (OMIM): 165720 - {Osteoarthritis susceptibility 1}, 165720
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 frzbENSDARG00000018383Danio rerio
 FRZBENSGALG00000002763Gallus gallus
 FrzbENSMUSG00000027004Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SFRP4 / Q6FHJ7 / secreted frizzled related protein 4ENSG0000010648350
FZD8 / Q9H461 / frizzled class receptor 8ENSG0000017728327
FZD7 / O75084 / frizzled class receptor 7ENSG0000015576026
FZD1 / Q9UP38 / frizzled class receptor 1ENSG0000015724025
FZD5 / Q13467 / frizzled class receptor 5ENSG0000016325125
FZD2 / Q14332 / frizzled class receptor 2ENSG0000018034025
FZD10 / Q9ULW2 / frizzled class receptor 10ENSG0000011143223
FZD9 / O00144 / frizzled class receptor 9ENSG0000018876322
FZD4 / Q9ULV1 / frizzled class receptor 4ENSG0000017480422
FZD3 / Q9NPG1 / frizzled class receptor 3ENSG0000010429021
FZD6 / O60353 / frizzled class receptor 6ENSG0000016493021
SFRP5 / Q5T4F7 / secreted frizzled related protein 5ENSG0000012005717
SFRP1 / Q8N474 / secreted frizzled related protein 1ENSG0000010433216
SMO / Q99835 / smoothened, frizzled class receptorENSG0000012860216
SFRP2 / Q96HF1 / secreted frizzled related protein 2ENSG0000014542314


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR018933  Netrin module, non-TIMP type
 IPR020067  Frizzled domain
 IPR026556  Secreted frizzled-related protein 3
 IPR035813  Secreted frizzled-related protein 3, NTR domain
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010721 negative regulation of cell development IEA
 biological_processGO:0014033 neural crest cell differentiation IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway NAS
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IBA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IGI
 biological_processGO:0045600 positive regulation of fat cell differentiation IDA
 biological_processGO:0060029 convergent extension involved in organogenesis IEA
 biological_processGO:0061037 negative regulation of cartilage development IEA
 biological_processGO:0061053 somite development IEA
 biological_processGO:0070367 negative regulation of hepatocyte differentiation IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090103 cochlea morphogenesis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017147 Wnt-protein binding IBA
 molecular_functionGO:0042813 Wnt-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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