ENSMUSG00000027004


Mus musculus

Features
Gene ID: ENSMUSG00000027004
  
Biological name :Frzb
  
Synonyms : Frzb / P97401 / Secreted frizzled-related protein 3
  
Possible biological names infered from orthology : frizzled related protein / Q92765
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C3
Gene start: 80411970
Gene end: 80447625
  
Corresponding Affymetrix probe sets: 10484307 (MoGene1.0st)   1416658_at (Mouse Genome 430 2.0 Array)   1448424_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028389
NCBI entrez gene - 20378     See in Manteia.
MGI - MGI:892032
RefSeq - NM_011356
RefSeq Peptide - NP_035486
swissprot - P97401
Ensembl - ENSMUSG00000027004
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 frzbENSDARG00000018383Danio rerio
 FRZBENSGALG00000002763Gallus gallus
 FRZBENSG00000162998Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sfrp4 / Q9Z1N6 / secreted frizzled-related protein 4 / Q6FHJ7*ENSMUSG0000002131951
Fzd5 / Q9EQD0 / Frizzled-5 / Q13467* / frizzled class receptor 5*ENSMUSG0000004500527
Fzd8 / Q61091 / Frizzled-8 / Q9H461* / frizzled class receptor 8*ENSMUSG0000003690426
Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*ENSMUSG0000004107526
Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*ENSMUSG0000005028825
Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*ENSMUSG0000004467425
Fzd10 / Q8BKG4 / Frizzled-10 / Q9ULW2* / frizzled class receptor 10*ENSMUSG0000008168323
Fzd9 / Q9R216 / Frizzled-9 / O00144* / frizzled class receptor 9*ENSMUSG0000004955123
Fzd3 / Q61086 / Frizzled-3 / Q9NPG1* / frizzled class receptor 3*ENSMUSG0000000798922
Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*ENSMUSG0000004979121
Fzd6 / Q61089 / Frizzled-6 / O60353* / frizzled class receptor 6*ENSMUSG0000002229721
Smo / P56726 / smoothened, frizzled class receptor / Q99835*ENSMUSG0000000176116
Sfrp1 / Q8C4U3 / Secreted frizzled-related protein 1 / Q8N474*ENSMUSG0000003154816
Sfrp5 / secreted frizzled-related sequence protein 5 / Q5T4F7* / secreted frizzled related protein 5*ENSMUSG0000001882216
Sfrp2 / P97299 / secreted frizzled-related protein 2 / Q96HF1*ENSMUSG0000002799614


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR018933  Netrin module, non-TIMP type
 IPR020067  Frizzled domain
 IPR026556  Secreted frizzled-related protein 3
 IPR035813  Secreted frizzled-related protein 3, NTR domain
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010721 negative regulation of cell development IDA
 biological_processGO:0014033 neural crest cell differentiation IEP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IBA
 biological_processGO:0042472 inner ear morphogenesis IGI
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0060029 convergent extension involved in organogenesis IGI
 biological_processGO:0061037 negative regulation of cartilage development IGI
 biological_processGO:0061053 somite development IEP
 biological_processGO:0070367 negative regulation of hepatocyte differentiation IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090103 cochlea morphogenesis IGI
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017147 Wnt-protein binding IPI
 molecular_functionGO:0042813 Wnt-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Ppp2catm1.2Nju/Ppp2catm1.2Nju
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ppp2catm1.2Nju/Ppp2catm1.2Nju
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ppp2catm1.2Nju/Ppp2catm1.2Nju
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Bcl11atm1.1Sbri/Bcl11atm1.1Sbri
Genetic Background: involves: BALB/cJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Seletm1Alb/Seletm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ppp2catm1.2Nju/Ppp2catm1.2Nju
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Frzbtm1.1Fplu/Frzbtm1.1Fplu
Genetic Background: B6.Cg-Frzbtm1.1Fplu

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Seletm1Alb/Seletm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prph2Rd2/Prph2Rd2
Genetic Background: C3.O20-Prph2Rd2

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ppp2catm1.2Nju/Ppp2catm1.2Nju
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Seletm1Alb/Seletm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Ppp2catm1.2Nju/Ppp2catm1.2Nju
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp2catm1.2Nju/Ppp2catm1.2Nju
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0004149 increased bone strength "increased ability of bone to endure the application of force without yielding or breaking" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp2catm1.2Nju/Ppp2catm1.2Nju
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0006282 abnormal posterior horn morphology "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl11atm1.1Sbri/Bcl11atm1.1Sbri
Genetic Background: involves: BALB/cJ

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Frzbtm1.1Fplu/Frzbtm1.1Fplu
Genetic Background: B6.Cg-Frzbtm1.1Fplu

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp2catm1.2Nju/Ppp2catm1.2Nju
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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