ENSMUSG00000031548


Mus musculus

Features
Gene ID: ENSMUSG00000031548
  
Biological name :Sfrp1
  
Synonyms : Q8C4U3 / Secreted frizzled-related protein 1 / Sfrp1
  
Possible biological names infered from orthology : Q8N474
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 23411502
Gene end: 23449632
  
Corresponding Affymetrix probe sets: 10570957 (MoGene1.0st)   1416594_at (Mouse Genome 430 2.0 Array)   1428136_at (Mouse Genome 430 2.0 Array)   1438620_x_at (Mouse Genome 430 2.0 Array)   1448395_at (Mouse Genome 430 2.0 Array)   1460187_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033952
NCBI entrez gene - 20377     See in Manteia.
MGI - MGI:892014
RefSeq - NM_013834
RefSeq - XM_011242128
RefSeq Peptide - NP_038862
swissprot - Q8C4U3
Ensembl - ENSMUSG00000031548
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sfrp1aENSDARG00000035521Danio rerio
 sfrp1bENSDARG00000057678Danio rerio
 SFRP1ENSGALG00000003473Gallus gallus
 SFRP1ENSG00000104332Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sfrp5 / secreted frizzled-related sequence protein 5 / Q5T4F7* / secreted frizzled related protein 5*ENSMUSG0000001882255
Sfrp2 / P97299 / secreted frizzled-related protein 2 / Q96HF1*ENSMUSG0000002799637
Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*ENSMUSG0000004467428
Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*ENSMUSG0000004107526
Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*ENSMUSG0000005028825
Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*ENSMUSG0000004979124
Fzd9 / Q9R216 / Frizzled-9 / O00144* / frizzled class receptor 9*ENSMUSG0000004955123
Fzd8 / Q61091 / Frizzled-8 / Q9H461* / frizzled class receptor 8*ENSMUSG0000003690422
Fzd5 / Q9EQD0 / Frizzled-5 / Q13467* / frizzled class receptor 5*ENSMUSG0000004500522
Fzd10 / Q8BKG4 / Frizzled-10 / Q9ULW2* / frizzled class receptor 10*ENSMUSG0000008168322
Fzd6 / Q61089 / Frizzled-6 / O60353* / frizzled class receptor 6*ENSMUSG0000002229721
Fzd3 / Q61086 / Frizzled-3 / Q9NPG1* / frizzled class receptor 3*ENSMUSG0000000798920
Smo / P56726 / smoothened, frizzled class receptor / Q99835*ENSMUSG0000000176119
Sfrp4 / Q9Z1N6 / secreted frizzled-related protein 4 / Q6FHJ7*ENSMUSG0000002131917
Frzb / P97401 / Secreted frizzled-related protein 3 / Q92765* / frizzled related protein*ENSMUSG0000002700417


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR018933  Netrin module, non-TIMP type
 IPR020067  Frizzled domain
 IPR026559  Secreted frizzled-related protein 1
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001657 ureteric bud development IEP
 biological_processGO:0001756 somitogenesis IEP
 biological_processGO:0001843 neural tube closure IGI
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IGI
 biological_processGO:0008585 female gonad development IGI
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0009950 dorsal/ventral axis specification IEA
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0010564 regulation of cell cycle process IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010975 regulation of neuron projection development IDA
 biological_processGO:0014034 neural crest cell fate commitment IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021915 neural tube development IGI
 biological_processGO:0030036 actin cytoskeleton organization ISO
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IGI
 biological_processGO:0033689 negative regulation of osteoblast proliferation IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading ISO
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043508 negative regulation of JUN kinase activity IGI
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0044345 stromal-epithelial cell signaling involved in prostate gland development IEP
 biological_processGO:0045578 negative regulation of B cell differentiation IMP
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0045671 negative regulation of osteoclast differentiation IMP
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046546 development of primary male sexual characteristics IGI
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046851 negative regulation of bone remodeling IEA
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEA
 biological_processGO:0048546 digestive tract morphogenesis IGI
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IDA
 biological_processGO:0060218 hematopoietic stem cell differentiation IEA
 biological_processGO:0060346 bone trabecula formation IMP
 biological_processGO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
 biological_processGO:0060687 regulation of branching involved in prostate gland morphogenesis IMP
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IEA
 biological_processGO:0071305 cellular response to vitamin D IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IEA
 biological_processGO:0071391 cellular response to estrogen stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071481 cellular response to X-ray IDA
 biological_processGO:0071504 cellular response to heparin IEA
 biological_processGO:0071542 dopaminergic neuron differentiation IDA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090175 regulation of establishment of planar polarity IGI
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IGI
 biological_processGO:0090244 Wnt signaling pathway involved in somitogenesis IGI
 biological_processGO:0090246 convergent extension involved in somitogenesis IGI
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1904956 regulation of midbrain dopaminergic neuron differentiation IGI
 biological_processGO:2000041 negative regulation of planar cell polarity pathway involved in axis elongation IGI
 biological_processGO:2000052 positive regulation of non-canonical Wnt signaling pathway IEA
 biological_processGO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification IEA
 biological_processGO:2000080 negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation IEA
 biological_processGO:2000270 negative regulation of fibroblast apoptotic process IEA
 biological_processGO:2000271 positive regulation of fibroblast apoptotic process IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rfx3tm1Wrth/Rfx3tm1Wrth
Genetic Background: involves: 129 * C57BL/6J

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rfx3tm1Wrth/Rfx3tm1Wrth
Genetic Background: involves: 129 * C57BL/6J

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rfx3tm1Wrth/Rfx3tm1Wrth
Genetic Background: involves: 129 * C57BL/6J

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0001158 abnormal prostate morphology "mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Nfasctm1.1Brp/Nfasctm1.1Brp,Tg(Plp1-Nfasc*)1Brp/0
Genetic Background: B6.Cg-Nfasctm1.1Brp Tg(Plp1-Nfasc*)1Brp

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rfx3tm1Wrth/Rfx3tm1Wrth
Genetic Background: involves: 129 * C57BL/6J

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+
Genetic Background: involves: 129 * C57BL/6

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2+
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rfx3tm1Wrth/Rfx3tm1Wrth
Genetic Background: involves: 129 * C57BL/6J

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Rfx3tm1Wrth/Rfx3tm1Wrth
Genetic Background: involves: 129 * C57BL/6J

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2+,Sfrp5tm1Aksh/Sfrp5tm1Aksh,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0004648 decreased thoracic vertebrae number "reduced number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rfx3tm1Wrth/Rfx3tm1Wrth
Genetic Background: involves: 129 * C57BL/6J

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

 MP:0009736 abnormal prostate gland branching morphogenesis "anomaly of the prostatic bud to repeatedly divide into lobules during development of the prostate gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfasctm1.1Brp/Nfasctm1.1Brp,Tg(Plp1-Nfasc*)1Brp/0
Genetic Background: B6.Cg-Nfasctm1.1Brp Tg(Plp1-Nfasc*)1Brp

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rfx3tm1Wrth/Rfx3tm1Wrth
Genetic Background: involves: 129 * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0011733 fused somites "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0012182 abnormal presomitic mesoderm morphology "any structural anomaly of the unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form" [MGI:anna]
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Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh
Genetic Background: involves: 129 * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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