ENSMUSG00000018822


Mus musculus

Features
Gene ID: ENSMUSG00000018822
  
Biological name :Sfrp5
  
Synonyms : secreted frizzled-related sequence protein 5 / Sfrp5
  
Possible biological names infered from orthology : Q5T4F7 / secreted frizzled related protein 5
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 42197971
Gene end: 42202252
  
Corresponding Affymetrix probe sets: 10467744 (MoGene1.0st)   1423023_at (Mouse Genome 430 2.0 Array)   1436075_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018966
NCBI entrez gene - 54612     See in Manteia.
MGI - MGI:1860298
RefSeq - NM_018780
RefSeq Peptide - NP_061250
swissprot - A0A0R4J001
Ensembl - ENSMUSG00000018822
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sfrp5ENSDARG00000039041Danio rerio
 SFRP5ENSGALG00000007515Gallus gallus
 SFRP5ENSG00000120057Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sfrp1 / Q8C4U3 / Secreted frizzled-related protein 1 / Q8N474*ENSMUSG0000003154855
Sfrp2 / P97299 / secreted frizzled-related protein 2 / Q96HF1*ENSMUSG0000002799640
Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*ENSMUSG0000004467426
Fzd9 / Q9R216 / Frizzled-9 / O00144* / frizzled class receptor 9*ENSMUSG0000004955125
Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*ENSMUSG0000004107525
Fzd5 / Q9EQD0 / Frizzled-5 / Q13467* / frizzled class receptor 5*ENSMUSG0000004500524
Fzd10 / Q8BKG4 / Frizzled-10 / Q9ULW2* / frizzled class receptor 10*ENSMUSG0000008168324
Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*ENSMUSG0000005028823
Fzd8 / Q61091 / Frizzled-8 / Q9H461* / frizzled class receptor 8*ENSMUSG0000003690423
Fzd3 / Q61086 / Frizzled-3 / Q9NPG1* / frizzled class receptor 3*ENSMUSG0000000798921
Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*ENSMUSG0000004979121
Fzd6 / Q61089 / Frizzled-6 / O60353* / frizzled class receptor 6*ENSMUSG0000002229721
Smo / P56726 / smoothened, frizzled class receptor / Q99835*ENSMUSG0000000176118
Frzb / P97401 / Secreted frizzled-related protein 3 / Q92765* / frizzled related protein*ENSMUSG0000002700417
Sfrp4 / Q9Z1N6 / secreted frizzled-related protein 4 / Q6FHJ7*ENSMUSG0000002131916


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR018933  Netrin module, non-TIMP type
 IPR020067  Frizzled domain
 IPR034860  Secreted frizzled-related protein 5
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030111 regulation of Wnt signaling pathway IEA
 biological_processGO:0030510 regulation of BMP signaling pathway IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2000057 negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Kcnj11Y12stop/Kcnj11Y12stop
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+
Genetic Background: involves: 129 * C57BL/6

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
Show

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crxtm1Clc/Crx+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sfrp5tm1Shwl/Sfrp5tm1Shwl
Genetic Background: either: 129S-Sfrp5tm1Shwl or B6.129S7-Sfrp5tm1Shwl

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnj11Y12stop/Kcnj11Y12stop
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Sfrp5tm1Shwl/Sfrp5tm1Shwl
Genetic Background: either: 129S-Sfrp5tm1Shwl or B6.129S7-Sfrp5tm1Shwl

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
Show

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0011733 fused somites "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]
Show

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0030324 abnormal anterior head development "any anomaly in the process in which the anatomical structures of the anterior part of the head are generated and organized" [GO:0097065, MGI:anna]
Show

Allelic Composition: Sfrp5tm1Shwl/Sfrp5tm1Shwl
Genetic Background: either: 129S-Sfrp5tm1Shwl or B6.129S7-Sfrp5tm1Shwl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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