ENSMUSG00000022297


Mus musculus

Features
Gene ID: ENSMUSG00000022297
  
Biological name :Fzd6
  
Synonyms : Frizzled-6 / Fzd6 / Q61089
  
Possible biological names infered from orthology : frizzled class receptor 6 / O60353
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: B3.1
Gene start: 39006034
Gene end: 39038188
  
Corresponding Affymetrix probe sets: 10423825 (MoGene1.0st)   1417301_at (Mouse Genome 430 2.0 Array)   1448662_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022906
Ensembl peptide - ENSMUSP00000136328
Ensembl peptide - ENSMUSP00000154162
Ensembl peptide - ENSMUSP00000154443
NCBI entrez gene - 14368     See in Manteia.
MGI - MGI:108474
RefSeq - XM_017316431
RefSeq - NM_001162494
RefSeq - NM_008056
RefSeq - XM_006520438
RefSeq - XM_011245454
RefSeq - XM_017316430
RefSeq Peptide - NP_001155966
RefSeq Peptide - NP_032082
swissprot - Q542J1
swissprot - Q61089
Ensembl - ENSMUSG00000022297
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01088508.1ENSDARG00000104874Danio rerio
 FZD6ENSGALG00000030626Gallus gallus
 FZD6ENSG00000164930Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fzd3 / Q61086 / Frizzled-3 / Q9NPG1* / frizzled class receptor 3*ENSMUSG0000000798948
Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*ENSMUSG0000004107532
Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*ENSMUSG0000004467432
Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*ENSMUSG0000005028831
Fzd5 / Q9EQD0 / Frizzled-5 / Q13467* / frizzled class receptor 5*ENSMUSG0000004500529
Fzd9 / Q9R216 / Frizzled-9 / O00144* / frizzled class receptor 9*ENSMUSG0000004955128
Fzd8 / Q61091 / Frizzled-8 / Q9H461* / frizzled class receptor 8*ENSMUSG0000003690428
Fzd10 / Q8BKG4 / Frizzled-10 / Q9ULW2* / frizzled class receptor 10*ENSMUSG0000008168328
Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*ENSMUSG0000004979124
Smo / P56726 / smoothened, frizzled class receptor / Q99835*ENSMUSG0000000176122
Sfrp4 / Q9Z1N6 / secreted frizzled-related protein 4 / Q6FHJ7*ENSMUSG0000002131911
Frzb / P97401 / Secreted frizzled-related protein 3 / Q92765* / frizzled related protein*ENSMUSG0000002700410
Sfrp2 / P97299 / secreted frizzled-related protein 2 / Q96HF1*ENSMUSG000000279969
Sfrp5 / secreted frizzled-related sequence protein 5 / Q5T4F7* / secreted frizzled related protein 5*ENSMUSG000000188229
Sfrp1 / Q8C4U3 / Secreted frizzled-related protein 1 / Q8N474*ENSMUSG000000315489


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR026543  Frizzled-6
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001736 establishment of planar polarity IGI
 biological_processGO:0001843 neural tube closure IGI
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030168 platelet activation IMP
 biological_processGO:0030901 midbrain development IGI
 biological_processGO:0033278 cell proliferation in midbrain IGI
 biological_processGO:0035567 non-canonical Wnt signaling pathway ISO
 biological_processGO:0035880 embryonic nail plate morphogenesis IMP
 biological_processGO:0042472 inner ear morphogenesis IGI
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0048105 establishment of body hair planar orientation IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IBA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane IDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017147 Wnt-protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042813 Wnt-activated receptor activity ISO


Pathways (from Reactome)
Pathway description
Ca2+ pathway
PCP/CE pathway
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Clocktm1.1Rep/Clocktm1.1Rep
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: En1tm1(PDGFB)Nist/En1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Astn2tm1.2Nat/Astn2tm1.2Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129S6/SvEvTac * BALB/cJ * C57BL/6 * CBA

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Clocktm1.1Rep/Clocktm1.1Rep
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Clocktm1.1Rep/Clocktm1.1Rep
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Clocktm1.1Rep/Clocktm1.1Rep
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thap1tm1.1Meeh/Thap1tm1.2Meeh
Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Seletm1Alb/Seletm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Clocktm1.1Rep/Clocktm1.1Rep
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004249 abnormal crista ampullaris morphology "anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004399 abnormal cochlear outer hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004492 abnormal orientation of inner hair cell stereociliary bundles "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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