ENSMUSG00000027996


Mus musculus

Features
Gene ID: ENSMUSG00000027996
  
Biological name :Sfrp2
  
Synonyms : P97299 / secreted frizzled-related protein 2 / Sfrp2
  
Possible biological names infered from orthology : Q96HF1
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E3
Gene start: 83766321
Gene end: 83774316
  
Corresponding Affymetrix probe sets: 10492798 (MoGene1.0st)   1448201_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029625
NCBI entrez gene - 20319     See in Manteia.
MGI - MGI:108078
RefSeq - NM_009144
RefSeq Peptide - NP_033170
swissprot - P97299
swissprot - Q3UI35
Ensembl - ENSMUSG00000027996
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sfrp2ENSDARG00000070050Danio rerio
 SFRP2ENSGALG00000009241Gallus gallus
 SFRP2ENSG00000145423Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sfrp5 / secreted frizzled-related sequence protein 5 / Q5T4F7* / secreted frizzled related protein 5*ENSMUSG0000001882242
Sfrp1 / Q8C4U3 / Secreted frizzled-related protein 1 / Q8N474*ENSMUSG0000003154839
Fzd9 / Q9R216 / Frizzled-9 / O00144* / frizzled class receptor 9*ENSMUSG0000004955126
Fzd8 / Q61091 / Frizzled-8 / Q9H461* / frizzled class receptor 8*ENSMUSG0000003690425
Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*ENSMUSG0000004467425
Fzd10 / Q8BKG4 / Frizzled-10 / Q9ULW2* / frizzled class receptor 10*ENSMUSG0000008168324
Fzd5 / Q9EQD0 / Frizzled-5 / Q13467* / frizzled class receptor 5*ENSMUSG0000004500524
Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*ENSMUSG0000004979123
Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*ENSMUSG0000004107523
Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*ENSMUSG0000005028823
Fzd6 / Q61089 / Frizzled-6 / O60353* / frizzled class receptor 6*ENSMUSG0000002229722
Fzd3 / Q61086 / Frizzled-3 / Q9NPG1* / frizzled class receptor 3*ENSMUSG0000000798921
Smo / P56726 / smoothened, frizzled class receptor / Q99835*ENSMUSG0000000176116
Frzb / P97401 / Secreted frizzled-related protein 3 / Q92765* / frizzled related protein*ENSMUSG0000002700415
Sfrp4 / Q9Z1N6 / secreted frizzled-related protein 4 / Q6FHJ7*ENSMUSG0000002131915


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR018933  Netrin module, non-TIMP type
 IPR020067  Frizzled domain
 IPR026558  Secreted frizzled-related protein 2
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IDA
 biological_processGO:0001756 somitogenesis IGI
 biological_processGO:0001843 neural tube closure IGI
 biological_processGO:0002063 chondrocyte development IMP
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003214 cardiac left ventricle morphogenesis IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IGI
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IDA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010950 positive regulation of endopeptidase activity IDA
 biological_processGO:0010975 regulation of neuron projection development IDA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021915 neural tube development IGI
 biological_processGO:0030111 regulation of Wnt signaling pathway IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IDA
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0030307 positive regulation of cell growth IDA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IGI
 biological_processGO:0031668 cellular response to extracellular stimulus IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0042662 negative regulation of mesodermal cell fate specification IGI
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043508 negative regulation of JUN kinase activity IGI
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IGI
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046546 development of primary male sexual characteristics IGI
 biological_processGO:0048546 digestive tract morphogenesis IGI
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060028 convergent extension involved in axis elongation IGI
 biological_processGO:0060349 bone morphogenesis IMP
 biological_processGO:0061056 sclerotome development IEP
 biological_processGO:0061185 negative regulation of dermatome development IDA
 biological_processGO:0071425 hematopoietic stem cell proliferation IDA
 biological_processGO:0071481 cellular response to X-ray IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090175 regulation of establishment of planar polarity IGI
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IGI
 biological_processGO:0090244 Wnt signaling pathway involved in somitogenesis IGI
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
 biological_processGO:1904956 regulation of midbrain dopaminergic neuron differentiation IGI
 biological_processGO:2000035 regulation of stem cell division IDA
 biological_processGO:2000041 negative regulation of planar cell polarity pathway involved in axis elongation IGI
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity IDA
 molecular_functionGO:0017147 Wnt-protein binding IPI
 molecular_functionGO:0042813 Wnt-activated receptor activity IBA
 molecular_functionGO:0048018 receptor ligand activity IDA
 molecular_functionGO:0061133 endopeptidase activator activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

Allelic Composition: Sfrp2tm1Aksh/Sfrp2tm1Aksh
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Sfrp2tm1Ktas/Sfrp2+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * CBA/N

Allelic Composition: Sfrp2tm1Ktas/Sfrp2+
Genetic Background: involves: 129X1/SvJ * CBA/N

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sfrp2tm1.1Brle/Sfrp2tm1.1Brle
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Kcnj11Y12stop/Kcnj11Y12stop
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * CBA/N

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+
Genetic Background: involves: 129 * C57BL/6

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2+
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prph2Rd2/Prph2Rd2
Genetic Background: C3.O20-Prph2Rd2

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnj11Y12stop/Kcnj11Y12stop
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il3tm1Glli/Il3tm1Glli
Genetic Background: B6.129S2-Il3tm1Glli

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
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Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * CBA/N

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002772 brachypodia "abnormally short feet" [J:31930, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Sfrp2tm1.1Brle/Sfrp2tm1.1Brle
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2+,Sfrp5tm1Aksh/Sfrp5tm1Aksh,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Sfrp2tm1.1Brle/Sfrp2tm1.1Brle
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0004083 polysyndactyly "greater than 5 digits present on an autopod with interdigital webbing also present" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Sfrp2tm1.1Brle/Sfrp2tm1.1Brle
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sfrp2tm1.1Brle/Sfrp2tm1.1Brle
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sfrp2tm1.1Brle/Sfrp2tm1.1Brle
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1.1Dbc/Nodaltm1.1Dbc
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004634 short metacarpal bones "reduced length of the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sfrp2tm1.1Brle/Sfrp2tm1.1Brle
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004635 short metatarsal bones "reduced length of the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sfrp2tm1.1Brle/Sfrp2tm1.1Brle
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004648 decreased thoracic vertebrae number "reduced number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sfrp2tm1.1Brle/Sfrp2tm1.1Brle
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nodaltm1.1Dbc/Nodaltm1.1Dbc
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * CBA/N

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006394 abnormal vertebral epiphyseal plate morphology "any structural anomaly in the lateral cartilaginous centers of ossification; may be found on the lateral, upper, and/or lower surfaces of the vertebrae at different times during development" [ISBN:0-914294-08-3 "Gray s Anatomy", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * CBA/N

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sfrp2tm1.1Brle/Sfrp2tm1.1Brle
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009874 abnormal interdigital cell death "change in the expected number of cells undergoing programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of normal digits" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * CBA/N

Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1.1Dbc/Nodaltm1.1Dbc
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0011733 fused somites "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic Background: involves: 129 * C57BL/6

 MP:0012182 abnormal presomitic mesoderm morphology "any structural anomaly of the unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form" [MGI:anna]
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Allelic Composition: Dkk1tm1Sia/Dkk1tm1Sia,Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh
Genetic Background: involves: 129 * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000009900 Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*  / reaction / complex






 

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