ENSMUSG00000041075


Mus musculus

Features
Gene ID: ENSMUSG00000041075
  
Biological name :Fzd7
  
Synonyms : Frizzled-7 / Fzd7 / Q61090
  
Possible biological names infered from orthology : frizzled class receptor 7 / O75084
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C2
Gene start: 59482424
Gene end: 59486955
  
Corresponding Affymetrix probe sets: 10346607 (MoGene1.0st)   1450043_at (Mouse Genome 430 2.0 Array)   1450044_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109884
NCBI entrez gene - 14369     See in Manteia.
MGI - MGI:108570
RefSeq - NM_008057
RefSeq Peptide - NP_032083
swissprot - Q61090
Ensembl - ENSMUSG00000041075
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzd7aENSDARG00000060004Danio rerio
 fzd7bENSDARG00000027589Danio rerio
 FZD7ENSGALG00000034973Gallus gallus
 FZD7ENSG00000155760Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*ENSMUSG0000004467478
Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*ENSMUSG0000005028877
Fzd8 / Q61091 / Frizzled-8 / Q9H461* / frizzled class receptor 8*ENSMUSG0000003690447
Fzd5 / Q9EQD0 / Frizzled-5 / Q13467* / frizzled class receptor 5*ENSMUSG0000004500547
Fzd10 / Q8BKG4 / Frizzled-10 / Q9ULW2* / frizzled class receptor 10*ENSMUSG0000008168344
Fzd9 / Q9R216 / Frizzled-9 / O00144* / frizzled class receptor 9*ENSMUSG0000004955142
Fzd3 / Q61086 / Frizzled-3 / Q9NPG1* / frizzled class receptor 3*ENSMUSG0000000798942
Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*ENSMUSG0000004979141
Fzd6 / Q61089 / Frizzled-6 / O60353* / frizzled class receptor 6*ENSMUSG0000002229740
Smo / P56726 / smoothened, frizzled class receptor / Q99835*ENSMUSG0000000176125
Sfrp4 / Q9Z1N6 / secreted frizzled-related protein 4 / Q6FHJ7*ENSMUSG0000002131916
Frzb / P97401 / Secreted frizzled-related protein 3 / Q92765* / frizzled related protein*ENSMUSG0000002700415
Sfrp1 / Q8C4U3 / Secreted frizzled-related protein 1 / Q8N474*ENSMUSG0000003154814
Sfrp5 / secreted frizzled-related sequence protein 5 / Q5T4F7* / secreted frizzled related protein 5*ENSMUSG0000001882213
Sfrp2 / P97299 / secreted frizzled-related protein 2 / Q96HF1*ENSMUSG0000002799612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR026552  Frizzled-7
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IEA
 biological_processGO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IMP
 biological_processGO:0035567 non-canonical Wnt signaling pathway IGI
 biological_processGO:0038031 non-canonical Wnt signaling pathway via JNK cascade IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042666 negative regulation of ectodermal cell fate specification IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048103 somatic stem cell division IMP
 biological_processGO:0060054 positive regulation of epithelial cell proliferation involved in wound healing IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060231 mesenchymal to epithelial transition IEA
 biological_processGO:2000726 negative regulation of cardiac muscle cell differentiation IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity ISO


Pathways (from Reactome)
Pathway description
PCP/CE pathway
Asymmetric localization of PCP proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt3atm1Amc/Wnt3a+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt11tm1Amc/Wnt11+
Genetic Background: involves: 129 * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Eif3cXs-J/Eif3c+
Genetic Background: B6C3Fe a/a-Eif3cXs-J/J

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Dvl3tm1Awb/Dvl3+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Dvl3tm1Awb/Dvl3+,Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt3atm1Amc/Wnt3a+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt3atm1Amc/Wnt3a+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt11tm1Amc/Wnt11+
Genetic Background: involves: 129 * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Eif3cXs-J/Eif3c+
Genetic Background: B6C3Fe a/a-Eif3cXs-J/J

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Eif3cXs-J/Eif3c+
Genetic Background: B6C3Fe a/a-Eif3cXs-J/J

Allelic Composition: Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt5atm1Amc/Wnt5a+
Genetic Background: involves: 129 * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0001723 disorganized vascular plexus 
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt5atm1Amc/Wnt5a+
Genetic Background: involves: 129 * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Dvl3tm1Awb/Dvl3+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Dvl3tm1Awb/Dvl3+,Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt3atm1Amc/Wnt3a+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt3atm1Amc/Wnt3a+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt11tm1Amc/Wnt11+
Genetic Background: involves: 129 * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt5atm1Amc/Wnt5a+
Genetic Background: involves: 129 * C57BL/6

 MP:0011203 abnormal parietal yolk sac morphology "any structural anomaly of the tissue that consists of two cellular layers (parietal endoderm and trophoblast) separated by a relatively thick nonvascular basement membrane (Reichert s membrane), and acts as a protective layer to supports and facilitates transport of nutrients between the uterine tissue and the yolk sac cavity" [PMID:1150659, PMID:21123814]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022997 Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*  / complex
 ENSMUSG00000015957 Wnt11 / P48615 / wingless-type MMTV integration site family, member 11 / O96014* / Wnt family member 11*  / complex
 ENSMUSG00000021994 Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*  / complex / reaction
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / reaction / complex






 

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