ENSMUSG00000050288


Mus musculus

Features
Gene ID: ENSMUSG00000050288
  
Biological name :Fzd2
  
Synonyms : Frizzled-2 / Fzd2 / Q9JIP6
  
Possible biological names infered from orthology : frizzled class receptor 2 / Q14332
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 102604396
Gene end: 102608058
  
Corresponding Affymetrix probe sets: 10381603 (MoGene1.0st)   1418532_at (Mouse Genome 430 2.0 Array)   1418533_s_at (Mouse Genome 430 2.0 Array)   1418534_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091463
NCBI entrez gene - 57265     See in Manteia.
MGI - MGI:1888513
RefSeq - NM_020510
RefSeq Peptide - NP_065256
swissprot - Q9JIP6
Ensembl - ENSMUSG00000050288
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzd2ENSDARG00000054438Danio rerio
 FZD2ENSGALG00000030847Gallus gallus
 FZD2ENSG00000180340Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*ENSMUSG0000004467478
Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*ENSMUSG0000004107577
Fzd8 / Q61091 / Frizzled-8 / Q9H461* / frizzled class receptor 8*ENSMUSG0000003690449
Fzd5 / Q9EQD0 / Frizzled-5 / Q13467* / frizzled class receptor 5*ENSMUSG0000004500548
Fzd10 / Q8BKG4 / Frizzled-10 / Q9ULW2* / frizzled class receptor 10*ENSMUSG0000008168345
Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*ENSMUSG0000004979142
Fzd9 / Q9R216 / Frizzled-9 / O00144* / frizzled class receptor 9*ENSMUSG0000004955142
Fzd3 / Q61086 / Frizzled-3 / Q9NPG1* / frizzled class receptor 3*ENSMUSG0000000798941
Fzd6 / Q61089 / Frizzled-6 / O60353* / frizzled class receptor 6*ENSMUSG0000002229739
Smo / P56726 / smoothened, frizzled class receptor / Q99835*ENSMUSG0000000176125
Sfrp4 / Q9Z1N6 / secreted frizzled-related protein 4 / Q6FHJ7*ENSMUSG0000002131915
Frzb / P97401 / Secreted frizzled-related protein 3 / Q92765* / frizzled related protein*ENSMUSG0000002700414
Sfrp1 / Q8C4U3 / Secreted frizzled-related protein 1 / Q8N474*ENSMUSG0000003154814
Sfrp5 / secreted frizzled-related sequence protein 5 / Q5T4F7* / secreted frizzled related protein 5*ENSMUSG0000001882213
Sfrp2 / P97299 / secreted frizzled-related protein 2 / Q96HF1*ENSMUSG0000002799612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR026550  Frizzled-2
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003149 membranous septum morphogenesis IGI
 biological_processGO:0003150 muscular septum morphogenesis IGI
 biological_processGO:0003151 outflow tract morphogenesis IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007608 sensory perception of smell IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030825 obsolete positive regulation of cGMP metabolic process IEA
 biological_processGO:0030855 epithelial cell differentiation IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060022 hard palate development IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060119 inner ear receptor cell development IGI
 biological_processGO:0060412 ventricular septum morphogenesis IGI
 biological_processGO:0090103 cochlea morphogenesis IGI
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017147 Wnt-protein binding IBA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity ISO


Pathways (from Reactome)
Pathway description
Ca2+ pathway
Asymmetric localization of PCP proteins
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD2, FZD5 and ROR2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Fzd1tm1.1Nat/Fzd1tm1.1Nat,Fzd2tm1.1Nat/Fzd2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt3atm1Amc/Wnt3a+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt11tm1Amc/Wnt11+
Genetic Background: involves: 129 * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Fzd1tm1.1Nat/Fzd1tm1.1Nat,Fzd2tm1.1Nat/Fzd2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Fzd1tm1.1Nat/Fzd1+,Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Dvl3tm1Awb/Dvl3+,Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt3atm1Amc/Wnt3a+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt11tm1Amc/Wnt11+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0000452 abnormal mouth morphology "anomalous structure or development of the oral cavity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Fzd1tm1.1Nat/Fzd1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0001723 disorganized vascular plexus 
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0001983 abnormal olfactory system physiology "abnormal function of the system relating to smell " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt5atm1Amc/Wnt5a+
Genetic Background: involves: 129 * C57BL/6

 MP:0004406 abnormal cochlear hair cell number "abnormal number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0009653 abnormal palate development "abnormal formation of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Fzd1tm1.1Nat/Fzd1+,Fzd2tm1.1Nat/Fzd2+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Dvl3tm1Awb/Dvl3+,Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt3atm1Amc/Wnt3a+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt11tm1Amc/Wnt11+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Wnt5atm1Amc/Wnt5a+
Genetic Background: involves: 129 * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0011203 abnormal parietal yolk sac morphology "any structural anomaly of the tissue that consists of two cellular layers (parietal endoderm and trophoblast) separated by a relatively thick nonvascular basement membrane (Reichert s membrane), and acts as a protective layer to supports and facilitates transport of nutrients between the uterine tissue and the yolk sac cavity" [PMID:1150659, PMID:21123814]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / complex
 ENSMUSG00000009900 Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*  / complex
 ENSMUSG00000012282 Wnt8a / Q64527 / wingless-type MMTV integration site family, member 8A / Q9H1J5* / Wnt family member 8A*  / complex
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex
 ENSMUSG00000022997 Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*  / complex
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / complex
 ENSMUSG00000036961 Wnt8b / wingless-type MMTV integration site family, member 8B / Q93098* / Wnt family member 8B*  / complex
 ENSMUSG00000029071 Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*  / complex
 ENSMUSG00000021994 Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*  / reaction / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / complex / reaction
 ENSMUSG00000024182 Axin1 / O15169*  / reaction / complex






 

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