ENSMUSG00000003233


Mus musculus

Features
Gene ID: ENSMUSG00000003233
  
Biological name :Dvl3
  
Synonyms : Dvl3 / Q61062 / Segment polarity DVL-3
  
Possible biological names infered from orthology : dishevelled segment polarity protein 3 / Q92997
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 20516982
Gene end: 20532520
  
Corresponding Affymetrix probe sets: 10434366 (MoGene1.0st)   1420457_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130925
Ensembl peptide - ENSMUSP00000003318
Ensembl peptide - ENSMUSP00000126082
NCBI entrez gene - 13544     See in Manteia.
MGI - MGI:108100
RefSeq - XM_011245824
RefSeq - NM_007889
RefSeq - XM_006521779
RefSeq - XM_006521780
RefSeq - XM_006521782
RefSeq Peptide - NP_001334105
RefSeq Peptide - NP_031915
swissprot - Q61062
swissprot - E9Q967
swissprot - E9Q150
Ensembl - ENSMUSG00000003233
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DVL3ENSGALG00000008414Gallus gallus
 DVL3ENSG00000161202Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*ENSMUSG0000002088869
Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*ENSMUSG0000002907164
Dixdc1 / Dixin / Q80Y83 / Q155Q3* / DIX domain containing 1*ENSMUSG0000003206412


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR001158  DIX domain
 IPR001478  PDZ domain
 IPR003351  Dishevelled protein domain
 IPR008339  Dishevelled family
 IPR008342  Dishevelled-3
 IPR015506  Dishevelled-related protein
 IPR024580  Dishevelled C-terminal
 IPR029071  Ubiquitin-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0003007 heart morphogenesis IGI
 biological_processGO:0003148 outflow tract septum morphogenesis IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IEA
 biological_processGO:0038031 non-canonical Wnt signaling pathway via JNK cascade IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IEA
 biological_processGO:0090103 cochlea morphogenesis IGI
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IGI
 biological_processGO:0150012 positive regulation of neuron projection arborization IEA
 biological_processGO:1903827 regulation of cellular protein localization IEA
 biological_processGO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation NAS
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:1990909 Wnt signalosome IDA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0030674 protein binding, bridging IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
WNT mediated activation of DVL
PCP/CE pathway
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dvl3tm1Awb/Dvl3+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Dvl3tm1Awb/Dvl3+,Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Cdh23ahl/Cdh23ahl,mt-Trm1
Genetic Background: either: A/J X (A/J x CAST/Ei)F1 or A/J X (CAST/Ei x A/J)F1

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Dvl3b2b2866Clo/Dvl3b2b2866Clo
Genetic Background: C57BL/6J-Dvl3b2b2866Clo

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Dvl3b2b2866Clo/Dvl3b2b2866Clo
Genetic Background: C57BL/6J-Dvl3b2b2866Clo

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Cdh23ahl/Cdh23ahl,mt-Trm1
Genetic Background: either: A/J X (A/J x CAST/Ei)F1 or A/J X (CAST/Ei x A/J)F1

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Abcb4tm1Bor/Abcb4tm1Bor
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Cdh23ahl/Cdh23ahl,mt-Trm1
Genetic Background: either: A/J X (A/J x CAST/Ei)F1 or A/J X (CAST/Ei x A/J)F1

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdh23ahl/Cdh23ahl,mt-Trm1
Genetic Background: either: A/J X (A/J x CAST/Ei)F1 or A/J X (CAST/Ei x A/J)F1

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dvl3b2b2866Clo/Dvl3b2b2866Clo
Genetic Background: C57BL/6J-Dvl3b2b2866Clo

 MP:0003456 absent tail "completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0004407 increased cochlear hair cell number "increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdh23ahl/Cdh23ahl,mt-Trm1
Genetic Background: either: A/J X (A/J x CAST/Ei)F1 or A/J X (CAST/Ei x A/J)F1

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004678 split xiphoid process "the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23ahl/Cdh23ahl,mt-Trm1
Genetic Background: either: A/J X (A/J x CAST/Ei)F1 or A/J X (CAST/Ei x A/J)F1

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0006198 enophthalmos "sinking or retraction of the eye back into the socket" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dvl3b2b2866Clo/Dvl3b2b2866Clo
Genetic Background: C57BL/6J-Dvl3b2b2866Clo

 MP:0006286 inner ear hypoplasia "underdevelopment or reduced size of inner ear structures, usually due to decreased cell number" [J:83662, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Dvl3tm1Awb/Dvl3+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Dvl3tm1Awb/Dvl3+,Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic Background: involves: 129 * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cdh23ahl/Cdh23ahl,mt-Trm1
Genetic Background: either: A/J X (A/J x CAST/Ei)F1 or A/J X (CAST/Ei x A/J)F1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0011666 double outlet right ventricle, ventricular defect committed to aorta "a form of DORV in which a ventricular septal defect is located just below the aorta; the left ventricular outflow is directed toward the aorta, resulting in aortic oxygen saturations that exceed pulmonary saturations; pulmonary stenosis is also often present" [MGI:csmith]
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Allelic Composition: Dvl3b2b2866Clo/Dvl3b2b2866Clo
Genetic Background: C57BL/6J-Dvl3b2b2866Clo

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
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Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022997 Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*  / complex
 ENSMUSG00000024182 Axin1 / O15169*  / reaction / complex
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / complex
 ENSMUSG00000004364 Cul3 / Q9JLV5 / Cullin-3 / Q13618*  / complex / reaction
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / complex / reaction
 ENSMUSG00000009900 Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*  / complex
 ENSMUSG00000036961 Wnt8b / wingless-type MMTV integration site family, member 8B / Q93098* / Wnt family member 8B*  / complex
 ENSMUSG00000012282 Wnt8a / Q64527 / wingless-type MMTV integration site family, member 8A / Q9H1J5* / Wnt family member 8A*  / complex
 ENSMUSG00000044674 Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*  / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000050288 Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*  / complex
 ENSMUSG00000026455 Klhl12 / Q8BZM0 / Kelch-like protein 12 / Q53G59* / kelch like family member 12*  / complex / reaction
 ENSMUSG00000024867 P70181 / Pip5k1b / Phosphatidylinositol 4-phosphate 5-kinase type-1 beta / O14986*  / complex / reaction
 ENSMUSG00000024387 Csnk2b / P67871 / Casein kinase II subunit beta / P67870* / casein kinase 2 beta*  / reaction
 ENSMUSG00000046707 O54833 / Csnk2a2 / Casein kinase II subunit alpha / P19784* / casein kinase 2 alpha 2*  / reaction
 ENSMUSG00000022433 Csnk1e / Q9JMK2 / Casein kinase I isoform epsilon / P49674* / Z98749.3* / casein kinase 1 epsilon*  / reaction
 ENSMUSG00000101523 Q60737 / Gm10031 / predicted pseudogene 10031 / Q8NEV1* / P68400* / CSNK2A1* / CSNK2A3* / casein kinase 2 alpha 1* / casein kinase 2 alpha 3*  / reaction






 

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