ENSMUSG00000026455


Mus musculus

Features
Gene ID: ENSMUSG00000026455
  
Biological name :Klhl12
  
Synonyms : Kelch-like protein 12 / Klhl12 / Q8BZM0
  
Possible biological names infered from orthology : kelch like family member 12 / Q53G59
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 134455531
Gene end: 134491018
  
Corresponding Affymetrix probe sets: 10350024 (MoGene1.0st)   1435786_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027725
Ensembl peptide - ENSMUSP00000107851
Ensembl peptide - ENSMUSP00000112227
NCBI entrez gene - 240756     See in Manteia.
MGI - MGI:2385619
RefSeq - XM_006529561
RefSeq - NM_001311136
RefSeq - NM_153128
RefSeq Peptide - NP_694768
RefSeq Peptide - NP_001298065
swissprot - Q8BZM0
Ensembl - ENSMUSG00000026455
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klhl12ENSDARG00000100631Danio rerio
 KLHL12 (1 of many)ENSDARG00000112728Danio rerio
 KLHL12ENSGALG00000000518Gallus gallus
 KLHL12ENSG00000117153Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klhl20 / Q8VCK5 / Kelch-like protein 20 / Q9Y2M5* / kelch like family member 20*ENSMUSG0000002670544
Klhl2 / Q8JZP3 / Kelch-like protein 2 / O95198* / kelch like family member 2*ENSMUSG0000003160542
Q6TDP3 / Plekhn1 / Kelch-like protein 17 / KLHL17* / Q6TDP4* / kelch like family member 17*ENSMUSG0000007848541
Klhl3 / E0CZ16 / Kelch-like protein 3 / Q9UH77* / kelch like family member 3*ENSMUSG0000001416440
Klhl18 / kelch like family member 18 / O94889*ENSMUSG0000005479239
Klhl28 / Q9CR40 / Kelch-like protein 28 / Q9NXS3* / kelch like family member 28*ENSMUSG0000002094838
Klhl8 / P59280 / Kelch-like protein 8 / Q9P2G9* / kelch like family member 8*ENSMUSG0000002931238
Klhl1 / Q9JI74 / Kelch-like protein 1 / Q9NR64* / kelch like family member 1*ENSMUSG0000002207638
Klhl5 / Mus musculus kelch-like 5 (Klhl5), transcript variant 2, mRNA. / Q96PQ7* / kelch like family member 5*ENSMUSG0000005492037
Klhl4 / kelch-like protein 4 isoform 3 / Q9C0H6* / kelch like family member 4*ENSMUSG0000002559737
Keap1 / Q9Z2X8 / Kelch-like ECH-associated protein 1 / Q14145*ENSMUSG0000000330836
Klhl10 / Q9D5V2 / kelch-like 10 / Q6JEL2* / kelch like family member 10*ENSMUSG0000000155832


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011043  Galactose oxidase/kelch, beta-propeller
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller
 IPR017096  BTB-kelch protein
 IPR037293  Galactose oxidase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006513 protein monoubiquitination IBA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport ISS
 biological_processGO:0014029 neural crest formation ISO
 biological_processGO:0014032 neural crest cell development ISS
 biological_processGO:0016055 Wnt signaling pathway ISO
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0048208 COPII vesicle coating IBA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0030127 COPII vesicle coat ISS
 cellular_componentGO:0030134 COPII-coated ER to Golgi transport vesicle IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Degradation of DVL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / complex / reaction
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000004364 Cul3 / Q9JLV5 / Cullin-3 / Q13618*  / complex






 

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