Manteia

ENSMUSG00000029312

Mus musculus

Features

Gene ID:	ENSMUSG00000029312

Biological name :	Klhl8

Synonyms :	Kelch-like protein 8 / Klhl8 / P59280

Possible biological names infered from orthology :	kelch like family member 8 / Q9P2G9

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	E5
Gene start:	103861973
Gene end:	103911259

Corresponding Affymetrix probe sets:	10531899 (MoGene1.0st) 1433526_at (Mouse Genome 430 2.0 Array) 1454637_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000031254 Ensembl peptide - ENSMUSP00000117671 Ensembl peptide - ENSMUSP00000108434 Ensembl peptide - ENSMUSP00000108430 NCBI entrez gene - 246293 See in Manteia. MGI - MGI:2179430 RefSeq - XM_017320883 RefSeq - NM_178741 RefSeq - XM_006534942 RefSeq Peptide - NP_848856 swissprot - D6REH9 swissprot - P59280 swissprot - A2AH59 swissprot - A2AH60 Ensembl - ENSMUSG00000029312

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Klhl20 / Q8VCK5 / Kelch-like protein 20 / Q9Y2M5* / kelch like family member 20*	ENSMUSG00000026705	37
Klhl5 / Mus musculus kelch-like 5 (Klhl5), transcript variant 2, mRNA. / Q96PQ7* / kelch like family member 5*	ENSMUSG00000054920	35
Klhl1 / Q9JI74 / Kelch-like protein 1 / Q9NR64* / kelch like family member 1*	ENSMUSG00000022076	35
Klhl12 / Q8BZM0 / Kelch-like protein 12 / Q53G59* / kelch like family member 12*	ENSMUSG00000026455	34
Klhl4 / kelch-like protein 4 isoform 3 / Q9C0H6* / kelch like family member 4*	ENSMUSG00000025597	34
Klhl3 / E0CZ16 / Kelch-like protein 3 / Q9UH77* / kelch like family member 3*	ENSMUSG00000014164	34
Q6TDP3 / Plekhn1 / Kelch-like protein 17 / KLHL17* / Q6TDP4* / kelch like family member 17*	ENSMUSG00000078485	34
Klhl2 / Q8JZP3 / Kelch-like protein 2 / O95198* / kelch like family member 2*	ENSMUSG00000031605	34
Klhl18 / kelch like family member 18 / O94889*	ENSMUSG00000054792	32
Klhl28 / Q9CR40 / Kelch-like protein 28 / Q9NXS3* / kelch like family member 28*	ENSMUSG00000020948	30
Keap1 / Q9Z2X8 / Kelch-like ECH-associated protein 1 / Q14145*	ENSMUSG00000003308	29
Klhl10 / Q9D5V2 / kelch-like 10 / Q6JEL2* / kelch like family member 10*	ENSMUSG00000001558	26

Protein motifs (from Interpro)

Interpro ID	Name
IPR000210	BTB/POZ domain
IPR006652	Kelch repeat type 1
IPR011043	Galactose oxidase/kelch, beta-propeller
IPR011333	SKP1/BTB/POZ domain superfamily
IPR011705	BTB/Kelch-associated
IPR015915	Kelch-type beta propeller
IPR017096	BTB-kelch protein
IPR030605	Kelch-like protein 8

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	IEA
biological_process	GO:0016567	protein ubiquitination	ISO
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0031463	Cul3-RING ubiquitin ligase complex	ISO
molecular_function	GO:0004842	ubiquitin-protein transferase activity	IBA
molecular_function	GO:0005515	protein binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Izumo1r^{tm2a(KOMP)Wtsi}/Izumo1r^{tm2a(KOMP)Wtsi} Genetic Background: C57BL/6N-Izumo1r^{tm2a(KOMP)Wtsi}/Wtsi

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr