ENSMUSG00000014164


Mus musculus

Features
Gene ID: ENSMUSG00000014164
  
Biological name :Klhl3
  
Synonyms : E0CZ16 / Kelch-like protein 3 / Klhl3
  
Possible biological names infered from orthology : kelch like family member 3 / Q9UH77
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 58000228
Gene end: 58113592
  
Corresponding Affymetrix probe sets: 10409629 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000089173
Ensembl peptide - ENSMUSP00000123701
NCBI entrez gene - 100503085     See in Manteia.
MGI - MGI:2445185
RefSeq - XM_006517013
RefSeq - NM_001195075
RefSeq - XM_006517010
RefSeq - XM_006517011
RefSeq - XM_006517008
RefSeq - XM_006517009
RefSeq Peptide - NP_001182004
swissprot - E0CZ16
Ensembl - ENSMUSG00000014164
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klhl3ENSDARG00000056647Danio rerio
 KLHL3ENSGALG00000039124Gallus gallus
 KLHL3ENSG00000146021Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klhl2 / Q8JZP3 / Kelch-like protein 2 / O95198* / kelch like family member 2*ENSMUSG0000003160570
Q6TDP3 / Plekhn1 / Kelch-like protein 17 / KLHL17* / Q6TDP4* / kelch like family member 17*ENSMUSG0000007848543
Klhl20 / Q8VCK5 / Kelch-like protein 20 / Q9Y2M5* / kelch like family member 20*ENSMUSG0000002670539
Klhl5 / Mus musculus kelch-like 5 (Klhl5), transcript variant 2, mRNA. / Q96PQ7* / kelch like family member 5*ENSMUSG0000005492037
Klhl12 / Q8BZM0 / Kelch-like protein 12 / Q53G59* / kelch like family member 12*ENSMUSG0000002645536
Klhl1 / Q9JI74 / Kelch-like protein 1 / Q9NR64* / kelch like family member 1*ENSMUSG0000002207635
Klhl4 / kelch-like protein 4 isoform 3 / Q9C0H6* / kelch like family member 4*ENSMUSG0000002559735
Klhl18 / kelch like family member 18 / O94889*ENSMUSG0000005479234
Klhl28 / Q9CR40 / Kelch-like protein 28 / Q9NXS3* / kelch like family member 28*ENSMUSG0000002094833
Keap1 / Q9Z2X8 / Kelch-like ECH-associated protein 1 / Q14145*ENSMUSG0000000330833
Klhl8 / P59280 / Kelch-like protein 8 / Q9P2G9* / kelch like family member 8*ENSMUSG0000002931233
Klhl10 / Q9D5V2 / kelch-like 10 / Q6JEL2* / kelch like family member 10*ENSMUSG0000000155830


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011041  Soluble quinoprotein glucose/sorbosone dehydrogenase
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller
 IPR017096  BTB-kelch protein
 IPR037293  Galactose oxidase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0050801 ion homeostasis ISO
 biological_processGO:0070294 renal sodium ion absorption IBA
 biological_processGO:0070936 protein K48-linked ubiquitination IBA
 biological_processGO:0072156 distal tubule morphogenesis ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex ISO
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdia4tm1b(EUCOMM)Wtsi/Pdia4tm1b(EUCOMM)Wtsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6N

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcnj11tm1b(EUCOMM)Wtsi/H

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcnj11tm1b(EUCOMM)Wtsi/H

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcnj11tm1b(EUCOMM)Wtsi/H

Allelic Composition: Klhl3tm2.1Esoh/Klhl3tm2.1Esoh
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0003030 acidemia "increased concentration of H-ion in the blood or a fall below normal in pH" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Klhl3tm2.1Esoh/Klhl3tm2.1Esoh
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0004217 salt-sensitive hypertension "sustained high blood pressure that is maintained with a normal or increase in the amount of salt consumed in the diet; blood pressure may return to normotensive with a low salt diet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(CAG-Lancl1)Pfw/Gt(ROSA)26Sortm2(CAG-Lancl1)Pfw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Klhl3tm1.1Esoh/Klhl3+
Genetic Background: involves: C57BL/6

Allelic Composition: Klhl3tm2.1Esoh/Klhl3tm2.1Esoh
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0004757 abnormal distal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex; it is partly responsible for the regulation of potassium, sodium, calcium, and pH through the endocrine system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klhl3tm2.1Esoh/Klhl3tm2.1Esoh
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Kcnj11tm1b(EUCOMM)Wtsi/Kcnj11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcnj11tm1b(EUCOMM)Wtsi/H

Allelic Composition: Klhl3tm2.1Esoh/Klhl3tm2.1Esoh
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0012339 hyperkalemia "excessively high concentrations of potassium in the circulating blood; may be due to renal insufficiency or to mineralocorticoid deficiency or resistance" [ISBN:0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Lancl1)Pfw/Gt(ROSA)26Sortm2(CAG-Lancl1)Pfw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Klhl3tm1.1Esoh/Klhl3+
Genetic Background: involves: C57BL/6

 MP:0012551 metabolic acidosis "decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Lancl1)Pfw/Gt(ROSA)26Sortm2(CAG-Lancl1)Pfw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Klhl3tm1.1Esoh/Klhl3+
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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