ENSMUSG00000022076


Mus musculus

Features
Gene ID: ENSMUSG00000022076
  
Biological name :Klhl1
  
Synonyms : Kelch-like protein 1 / Klhl1 / Q9JI74
  
Possible biological names infered from orthology : kelch like family member 1 / Q9NR64
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E2.1
Gene start: 96102736
Gene end: 96519102
  
Corresponding Affymetrix probe sets: 10421934 (MoGene1.0st)   1436465_at (Mouse Genome 430 2.0 Array)   1449241_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022666
NCBI entrez gene - 93688     See in Manteia.
MGI - MGI:2136335
RefSeq - NM_053105
RefSeq Peptide - NP_444335
swissprot - Q9JI74
Ensembl - ENSMUSG00000022076
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klhl5ENSDARG00000062122Danio rerio
 KLHL1ENSGALG00000016907Gallus gallus
 KLHL1ENSG00000150361Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klhl4 / kelch-like protein 4 isoform 3 / Q9C0H6* / kelch like family member 4*ENSMUSG0000002559762
Klhl5 / Mus musculus kelch-like 5 (Klhl5), transcript variant 2, mRNA. / Q96PQ7* / kelch like family member 5*ENSMUSG0000005492061
Klhl20 / Q8VCK5 / Kelch-like protein 20 / Q9Y2M5* / kelch like family member 20*ENSMUSG0000002670534
Q6TDP3 / Plekhn1 / Kelch-like protein 17 / KLHL17* / Q6TDP4* / kelch like family member 17*ENSMUSG0000007848531
Klhl28 / Q9CR40 / Kelch-like protein 28 / Q9NXS3* / kelch like family member 28*ENSMUSG0000002094830
Klhl3 / E0CZ16 / Kelch-like protein 3 / Q9UH77* / kelch like family member 3*ENSMUSG0000001416430
Klhl8 / P59280 / Kelch-like protein 8 / Q9P2G9* / kelch like family member 8*ENSMUSG0000002931230
Klhl18 / kelch like family member 18 / O94889*ENSMUSG0000005479230
Klhl2 / Q8JZP3 / Kelch-like protein 2 / O95198* / kelch like family member 2*ENSMUSG0000003160530
Klhl12 / Q8BZM0 / Kelch-like protein 12 / Q53G59* / kelch like family member 12*ENSMUSG0000002645528
Keap1 / Q9Z2X8 / Kelch-like ECH-associated protein 1 / Q14145*ENSMUSG0000000330827
Klhl10 / Q9D5V2 / kelch-like 10 / Q6JEL2* / kelch like family member 10*ENSMUSG0000000155825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0021680 cerebellar Purkinje cell layer development IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IBA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
Show

Allelic Composition: Ptk2tm1Imeg/Ptk2+
Genetic Background: CBA.Cg-Ptk2tm1Imeg

Allelic Composition: Klhl1/Atxn8ostm1.1Mdk/Klhl1/Atxn8ostm1.1Mdk
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Klhl1/Atxn8ostm1.1Mdk/Klhl1/Klhl1as+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptk2tm1Imeg/Ptk2+
Genetic Background: CBA.Cg-Ptk2tm1Imeg

Allelic Composition: Klhl1/Atxn8ostm1.1Mdk/Klhl1/Atxn8ostm1.1Mdk
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Klhl1/Atxn8ostm1.1Mdk/Klhl1/Klhl1as+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Klhl1/Atxn8ostm1.1Mdk/Klhl1/Atxn8ostm1.1Mdk
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Klhl1/Atxn8ostm1.1Mdk/Klhl1/Klhl1as+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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