ENSMUSG00000026705


Mus musculus

Features
Gene ID: ENSMUSG00000026705
  
Biological name :Klhl20
  
Synonyms : Kelch-like protein 20 / Klhl20 / Q8VCK5
  
Possible biological names infered from orthology : kelch like family member 20 / Q9Y2M5
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H2.1
Gene start: 161088375
Gene end: 161131511
  
Corresponding Affymetrix probe sets: 10359405 (MoGene1.0st)   1425664_at (Mouse Genome 430 2.0 Array)   1454994_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107238
Ensembl peptide - ENSMUSP00000114044
Ensembl peptide - ENSMUSP00000141213
NCBI entrez gene - 226541     See in Manteia.
MGI - MGI:2444855
RefSeq - NM_001039482
RefSeq Peptide - NP_001034571
swissprot - Q8BL42
swissprot - Q8VCK5
Ensembl - ENSMUSG00000026705
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klhl20ENSDARG00000038801Danio rerio
 KLHL20ENSGALG00000036931Gallus gallus
 KLHL20ENSG00000076321Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6TDP3 / Plekhn1 / Kelch-like protein 17 / KLHL17* / Q6TDP4* / kelch like family member 17*ENSMUSG0000007848547
Klhl2 / Q8JZP3 / Kelch-like protein 2 / O95198* / kelch like family member 2*ENSMUSG0000003160542
Klhl1 / Q9JI74 / Kelch-like protein 1 / Q9NR64* / kelch like family member 1*ENSMUSG0000002207642
Klhl12 / Q8BZM0 / Kelch-like protein 12 / Q53G59* / kelch like family member 12*ENSMUSG0000002645541
Klhl5 / Mus musculus kelch-like 5 (Klhl5), transcript variant 2, mRNA. / Q96PQ7* / kelch like family member 5*ENSMUSG0000005492041
Klhl3 / E0CZ16 / Kelch-like protein 3 / Q9UH77* / kelch like family member 3*ENSMUSG0000001416441
Klhl4 / kelch-like protein 4 isoform 3 / Q9C0H6* / kelch like family member 4*ENSMUSG0000002559740
Klhl28 / Q9CR40 / Kelch-like protein 28 / Q9NXS3* / kelch like family member 28*ENSMUSG0000002094839
Klhl8 / P59280 / Kelch-like protein 8 / Q9P2G9* / kelch like family member 8*ENSMUSG0000002931238
Klhl18 / kelch like family member 18 / O94889*ENSMUSG0000005479238
Keap1 / Q9Z2X8 / Kelch-like ECH-associated protein 1 / Q14145*ENSMUSG0000000330836
Klhl10 / Q9D5V2 / kelch-like 10 / Q6JEL2* / kelch like family member 10*ENSMUSG0000000155834


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011043  Galactose oxidase/kelch, beta-propeller
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller
 IPR017096  BTB-kelch protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006895 Golgi to endosome transport ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0035455 response to interferon-alpha IBA
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:1990390 protein K33-linked ubiquitination ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016605 PML body IBA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019964 interferon-gamma binding ISO


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0008852 retinal neovascularization "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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