ENSG00000076321


Homo sapiens

Features
Gene ID: ENSG00000076321
  
Biological name :KLHL20
  
Synonyms : kelch like family member 20 / KLHL20 / Q9Y2M5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q25.1
Gene start: 173714941
Gene end: 173786702
  
Corresponding Affymetrix probe sets: 204176_at (Human Genome U133 Plus 2.0 Array)   204177_s_at (Human Genome U133 Plus 2.0 Array)   210634_at (Human Genome U133 Plus 2.0 Array)   210635_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000209884
NCBI entrez gene - 27252     See in Manteia.
OMIM - 617679
RefSeq - XM_017001054
RefSeq - NM_014458
RefSeq - XM_011509420
RefSeq - XM_017001052
RefSeq - XM_017001053
RefSeq - XM_005245093
RefSeq Peptide - NP_055273
swissprot - Q9Y2M5
swissprot - A0A024R940
Ensembl - ENSG00000076321
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klhl20ENSDARG00000038801Danio rerio
 KLHL20ENSGALG00000036931Gallus gallus
 Klhl20ENSMUSG00000026705Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLHL17 / Q6TDP4 / kelch like family member 17ENSG0000018796146
KLHL1 / Q9NR64 / kelch like family member 1ENSG0000015036142
KLHL2 / O95198 / kelch like family member 2ENSG0000010946642
KLHL5 / Q96PQ7 / kelch like family member 5ENSG0000010979041
KLHL12 / Q53G59 / kelch like family member 12ENSG0000011715341
KLHL3 / Q9UH77 / kelch like family member 3ENSG0000014602141
KLHL28 / Q9NXS3 / kelch like family member 28ENSG0000017945439
KLHL8 / Q9P2G9 / kelch like family member 8ENSG0000014533239
KLHL4 / Q9C0H6 / kelch like family member 4ENSG0000010227139
KLHL18 / O94889 / kelch like family member 18ENSG0000011464838
KEAP1 / Q14145 / kelch like ECH associated protein 1ENSG0000007999936
KLHL10 / Q6JEL2 / kelch like family member 10ENSG0000016159434


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller
 IPR017096  BTB-kelch protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006895 Golgi to endosome transport IMP
 biological_processGO:0007010 cytoskeleton organization TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0035455 response to interferon-alpha TAS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:1990390 protein K33-linked ubiquitination IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0016605 PML body IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019964 interferon-gamma binding IDA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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