ENSG00000109466


Homo sapiens

Features
Gene ID: ENSG00000109466
  
Biological name :KLHL2
  
Synonyms : kelch like family member 2 / KLHL2 / O95198
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q32.3
Gene start: 165207618
Gene end: 165323156
  
Corresponding Affymetrix probe sets: 219157_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421324
Ensembl peptide - ENSP00000408974
Ensembl peptide - ENSP00000421844
Ensembl peptide - ENSP00000437526
Ensembl peptide - ENSP00000424198
Ensembl peptide - ENSP00000424108
Ensembl peptide - ENSP00000422113
Ensembl peptide - ENSP00000226725
NCBI entrez gene - 11275     See in Manteia.
OMIM - 605774
RefSeq - XM_017007677
RefSeq - NM_001161521
RefSeq - NM_001161522
RefSeq - NM_007246
RefSeq - XM_011531572
RefSeq - XM_011531575
RefSeq - XM_011531576
RefSeq - XM_017007674
RefSeq - XM_017007675
RefSeq - XM_017007676
RefSeq Peptide - NP_001317952
RefSeq Peptide - NP_001317953
RefSeq Peptide - NP_009177
RefSeq Peptide - NP_001154993
RefSeq Peptide - NP_001154994
swissprot - D6R9G5
swissprot - B4DFZ5
swissprot - O95198
swissprot - E9PEX9
swissprot - D6RGC3
swissprot - D6RAP5
Ensembl - ENSG00000109466
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klhl2ENSDARG00000061786Danio rerio
 KLHL2ENSGALG00000009554Gallus gallus
 Klhl2ENSMUSG00000031605Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLHL3 / Q9UH77 / kelch like family member 3ENSG0000014602176
KLHL17 / Q6TDP4 / kelch like family member 17ENSG0000018796147
KLHL20 / Q9Y2M5 / kelch like family member 20ENSG0000007632142
KLHL12 / Q53G59 / kelch like family member 12ENSG0000011715340
KLHL5 / Q96PQ7 / kelch like family member 5ENSG0000010979039
KLHL1 / Q9NR64 / kelch like family member 1ENSG0000015036138
KLHL18 / O94889 / kelch like family member 18ENSG0000011464837
KLHL4 / Q9C0H6 / kelch like family member 4ENSG0000010227137
KEAP1 / Q14145 / kelch like ECH associated protein 1ENSG0000007999936
KLHL28 / Q9NXS3 / kelch like family member 28ENSG0000017945436
KLHL8 / Q9P2G9 / kelch like family member 8ENSG0000014533235
KLHL10 / Q6JEL2 / kelch like family member 10ENSG0000016159434


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller
 IPR017096  BTB-kelch protein
 IPR037293  Galactose oxidase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination ISS
 biological_processGO:0043687 post-translational protein modification TAS
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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