ENSG00000117153


Homo sapiens

Features
Gene ID: ENSG00000117153
  
Biological name :KLHL12
  
Synonyms : kelch like family member 12 / KLHL12 / Q53G59
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q32.1
Gene start: 202891100
Gene end: 202928636
  
Corresponding Affymetrix probe sets: 219931_s_at (Human Genome U133 Plus 2.0 Array)   225068_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356227
Ensembl peptide - ENSP00000356228
Ensembl peptide - ENSP00000356230
NCBI entrez gene - 59349     See in Manteia.
OMIM - 614522
RefSeq - XM_017001995
RefSeq - NM_001303051
RefSeq - NM_001303109
RefSeq - NM_021633
RefSeq - XM_011509835
RefSeq - XM_011509836
RefSeq - XM_011509837
RefSeq Peptide - NP_001289980
RefSeq Peptide - NP_001290038
RefSeq Peptide - NP_067646
swissprot - Q53G59
swissprot - Q9H7R2
swissprot - J3QSX3
Ensembl - ENSG00000117153
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klhl12ENSDARG00000100631Danio rerio
 KLHL12 (1 of many)ENSDARG00000112728Danio rerio
 KLHL12ENSGALG00000000518Gallus gallus
 Klhl12ENSMUSG00000026455Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLHL20 / Q9Y2M5 / kelch like family member 20ENSG0000007632144
KLHL2 / O95198 / kelch like family member 2ENSG0000010946642
KLHL17 / Q6TDP4 / kelch like family member 17ENSG0000018796141
KLHL3 / Q9UH77 / kelch like family member 3ENSG0000014602140
KLHL18 / O94889 / kelch like family member 18ENSG0000011464839
KLHL28 / Q9NXS3 / kelch like family member 28ENSG0000017945438
KLHL8 / Q9P2G9 / kelch like family member 8ENSG0000014533238
KLHL1 / Q9NR64 / kelch like family member 1ENSG0000015036138
KLHL5 / Q96PQ7 / kelch like family member 5ENSG0000010979037
KLHL4 / Q9C0H6 / kelch like family member 4ENSG0000010227136
KEAP1 / Q14145 / kelch like ECH associated protein 1ENSG0000007999936
KLHL10 / Q6JEL2 / kelch like family member 10ENSG0000016159432


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller
 IPR017096  BTB-kelch protein
 IPR037293  Galactose oxidase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006513 protein monoubiquitination IDA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IMP
 biological_processGO:0014029 neural crest formation IMP
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0016055 Wnt signaling pathway IMP
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0048208 COPII vesicle coating IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030127 COPII vesicle coat IDA
 cellular_componentGO:0030134 COPII-coated ER to Golgi transport vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Degradation of DVL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / reaction / complex
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000161202 DVL3 / Q92997 / dishevelled segment polarity protein 3  / complex / reaction
 ENSG00000036257 CUL3 / Q13618 / cullin 3  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr