ENSG00000145332


Homo sapiens

Features
Gene ID: ENSG00000145332
  
Biological name :KLHL8
  
Synonyms : kelch like family member 8 / KLHL8 / Q9P2G9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q22.1
Gene start: 87160103
Gene end: 87240314
  
Corresponding Affymetrix probe sets: 1561206_at (Human Genome U133 Plus 2.0 Array)   226874_at (Human Genome U133 Plus 2.0 Array)   242648_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000273963
Ensembl peptide - ENSP00000424131
Ensembl peptide - ENSP00000426361
Ensembl peptide - ENSP00000426451
Ensembl peptide - ENSP00000408854
NCBI entrez gene - 57563     See in Manteia.
OMIM - 611967
RefSeq - NM_001292006
RefSeq - NM_001292003
RefSeq - NM_001292007
RefSeq - NM_020803
RefSeq Peptide - NP_001278936
RefSeq Peptide - NP_001278932
RefSeq Peptide - NP_001278935
RefSeq Peptide - NP_065854
swissprot - Q68DU9
swissprot - D6RGH5
swissprot - Q9P2G9
Ensembl - ENSG00000145332
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klhl8ENSDARG00000101270Danio rerio
 KLHL8ENSGALG00000011017Gallus gallus
 Klhl8ENSMUSG00000029312Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLHL20 / Q9Y2M5 / kelch like family member 20ENSG0000007632138
KLHL1 / Q9NR64 / kelch like family member 1ENSG0000015036137
KLHL5 / Q96PQ7 / kelch like family member 5ENSG0000010979036
KLHL17 / Q6TDP4 / kelch like family member 17ENSG0000018796135
KLHL3 / Q9UH77 / kelch like family member 3ENSG0000014602135
KLHL12 / Q53G59 / kelch like family member 12ENSG0000011715334
KLHL2 / O95198 / kelch like family member 2ENSG0000010946634
KLHL4 / Q9C0H6 / kelch like family member 4ENSG0000010227134
KLHL18 / O94889 / kelch like family member 18ENSG0000011464832
KLHL28 / Q9NXS3 / kelch like family member 28ENSG0000017945431
KEAP1 / Q14145 / kelch like ECH associated protein 1ENSG0000007999929
KLHL10 / Q6JEL2 / kelch like family member 10ENSG0000016159427


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011043  Galactose oxidase/kelch, beta-propeller
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller
 IPR017096  BTB-kelch protein
 IPR030605  Kelch-like protein 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0016567 protein ubiquitination IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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