ENSGALG00000000518


Gallus gallus

Features
Gene ID: ENSGALG00000000518
  
Biological name :KLHL12
  
Synonyms : kelch like family member 12 / KLHL12
  
Possible biological names infered from orthology : Kelch-like protein 12 / Q53G59 / Q8BZM0
  
Species: Gallus gallus
  
Chr. number: 26
Strand: 1
Band:
Gene start: 499824
Gene end: 513711
  
Corresponding Affymetrix probe sets: Gga.12644.1.S1_a_at (Chicken Array)   Gga.12644.1.S1_x_at (Chicken Array)   Gga.12644.2.S1_a_at (Chicken Array)   Gga.12644.2.S1_x_at (Chicken Array)   GgaAffx.325.1.S1_s_at (Chicken Array)   GgaAffx.325.7.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000000711
Ensembl peptide - ENSGALP00000057126
NCBI entrez gene - 101748977     See in Manteia.
RefSeq - XM_015298734
swissprot - F1NLC2
Ensembl - ENSGALG00000000518
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klhl12ENSDARG00000100631Danio rerio
 KLHL12 (1 of many)ENSDARG00000112728Danio rerio
 KLHL12ENSG00000117153Homo sapiens
 Klhl12ENSMUSG00000026455Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KLHL20 / kelch-like protein 20 / Q8VCK5* / Q9Y2M5* / kelch like family member 20*ENSGALG0000003693144
KLHL2 / kelch like family member 2 / O95198* / Q8JZP3* / Kelch-like protein 2 *ENSGALG0000000955441
KLHL17 / kelch like family member 17 / Q6TDP3* / Q6TDP4* / Plekhn1* / Kelch-like protein 17 *ENSGALG0000000219941
KLHL18 / kelch-like protein 18 / O94889* / kelch like family member 18*ENSGALG0000000558240
KLHL3 / kelch like family member 3 / E0CZ16* / Q9UH77* / Kelch-like protein 3 *ENSGALG0000003912440
KLHL1 / kelch like family member 1 / Q9JI74* / Q9NR64* / Kelch-like protein 1 *ENSGALG0000001690738
KLHL8 / kelch like family member 8 / P59280* / Q9P2G9* / Kelch-like protein 8 *ENSGALG0000001101738
KLHL28 / kelch like family member 28 / Q9CR40* / Q9NXS3* / Kelch-like protein 28 *ENSGALG0000001248937
KLHL4 / kelch like family member 4 / Q9C0H6* / kelch-like protein 4 isoform 3 *ENSGALG0000000687736
KLHL5 / kelch like family member 5 / Q96PQ7* / Mus musculus kelch-like 5 (Klhl5), transcript variant 2, mRNA.*ENSGALG0000003138836
KLHL10 / kelch like family member 10 / Q6JEL2* / Q9D5V2* / kelch-like 10*ENSGALG0000000362432


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR017096  BTB-kelch protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IEA
 biological_processGO:0014029 neural crest formation IEA
 biological_processGO:0014032 neural crest cell development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0048208 COPII vesicle coating IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0030127 COPII vesicle coat IEA
 cellular_componentGO:0030134 COPII-coated ER to Golgi transport vesicle IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Degradation of DVL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008414 DVL3 / dishevelled segment polarity protein 3 / Q61062* / Q92997* / Segment polarity DVL-3 *  / complex / reaction
 ENSGALG00000005108 CUL3 / cullin 3 / Q13618* / Q9JLV5*  / complex
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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