ENSGALG00000005108


Gallus gallus

Features
Gene ID: ENSGALG00000005108
  
Biological name :CUL3
  
Synonyms : CUL3 / cullin 3
  
Possible biological names infered from orthology : Q13618 / Q9JLV5
  
Species: Gallus gallus
  
Chr. number: 9
Strand: -1
Band:
Gene start: 8405073
Gene end: 8455900
  
Corresponding Affymetrix probe sets: Gga.4769.1.S1_s_at (Chicken Array)   GgaAffx.26407.1.S1_at (Chicken Array)   GgaAffx.26407.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000008177
NCBI entrez gene - 424804     See in Manteia.
RefSeq - XM_422620
swissprot - E1BYQ3
Ensembl - ENSGALG00000005108
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cul3aENSDARG00000038967Danio rerio
 cul3bENSDARG00000100108Danio rerio
 CUL3ENSG00000036257Homo sapiens
 Cul3ENSMUSG00000004364Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CUL4A / cullin 4A / Q13619* / Q3TCH7*ENSGALG0000001683038
CUL4B / cullin 4B / A2A432* / Q13620*ENSGALG0000000855938
CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*ENSGALG0000003694130
CUL2 / cullin-2 / Q13617* / Q9D4H8*ENSGALG0000000709526
CUL5 / cullin 5 / Q93034*ENSGALG0000001716524


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR011991  ArsR-like helix-turn-helix domain
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001831 trophectodermal cellular morphogenesis IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IEA
 biological_processGO:0007080 mitotic metaphase plate congression IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0017145 stem cell division IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IEA
 biological_processGO:0040016 embryonic cleavage IEA
 biological_processGO:0043149 stress fiber assembly IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0044346 fibroblast apoptotic process IEA
 biological_processGO:0045842 positive regulation of mitotic metaphase/anaphase transition IEA
 biological_processGO:0048208 COPII vesicle coating IEA
 biological_processGO:0071630 nuclear protein quality control by the ubiquitin-proteasome system IEA
 biological_processGO:0072576 liver morphogenesis IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005827 polar microtubule IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IBA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IEA
 cellular_componentGO:0036126 sperm flagellum IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005112 Notch binding IEA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0031208 POZ domain binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Degradation of DVL
Hedgehog on state
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000011630 GLI2 / GLI family zinc finger 2 / P10070* / Q0VGT2* / Zinc finger protein GLI2 *  / complex / reaction
 ENSGALG00000040266 GLI3 / GLI family zinc finger 3 / P10071* / Q61602* / Transcriptional activator GLI3 Transcriptional repressor GLI3R*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000000518 KLHL12 / kelch like family member 12 / Q53G59* / Q8BZM0* / Kelch-like protein 12 *  / complex
 ENSGALG00000009939 SPOP / speckle type BTB/POZ protein / Gm5286* / Gm5773* / Gm9117* / Gm9125* / Tdpoz5* / Gm4778* / Gm4858* / O43791* / P0DMR5* / P0DMR6* / Q6YCH2* / Q6ZWS8* / Q717B2* / Q717B4* / Tdpoz1* / T...  / complex
 ENSGALG00000005108 CUL3 / cullin 3 / Q13618* / Q9JLV5*  / complex
 ENSGALG00000008414 DVL3 / dishevelled segment polarity protein 3 / Q61062* / Q92997* / Segment polarity DVL-3 *  / complex / reaction






 

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