ENSGALG00000011630


Gallus gallus

Features
Gene ID: ENSGALG00000011630
  
Biological name :GLI2
  
Synonyms : GLI2 / GLI family zinc finger 2
  
Possible biological names infered from orthology : P10070 / Q0VGT2 / Zinc finger protein GLI2
  
Species: Gallus gallus
  
Chr. number: 7
Strand: 1
Band:
Gene start: 25930783
Gene end: 26109391
  
Corresponding Affymetrix probe sets: Gga.1898.1.S1_at (Chicken Array)   Gga.4969.1.S1_at (Chicken Array)   GgaAffx.7399.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000018975
Ensembl peptide - ENSGALP00000060206
Ensembl peptide - ENSGALP00000049184
Ensembl peptide - ENSGALP00000044160
NCBI entrez gene - 395956     See in Manteia.
RefSeq - XM_015289787
RefSeq - NM_001271901
RefSeq - NM_001271902
RefSeq - XM_015289786
RefSeq Peptide - NP_001258831
RefSeq Peptide - NP_001258830
swissprot - A0A1L1RN49
swissprot - A0A1D5P8Y5
swissprot - A0A1D5NUY9
swissprot - F1P5L2
Ensembl - ENSGALG00000011630
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gli2bENSDARG00000020884Danio rerio
 GLI2ENSG00000074047Homo sapiens
 Gli2ENSMUSG00000048402Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GLI3 / GLI family zinc finger 3 / P10071* / Q61602* / Transcriptional activator GLI3 Transcriptional repressor GLI3R*ENSGALG0000004026648
GLIS3 / GLIS family zinc finger 3 / Q6XP49* / Q8NEA6* / Zinc finger protein GLIS3 *ENSGALG0000001018015
GLIS1 / GLIS family zinc finger 1 / Q8K1M4* / Q8NBF1* / Zinc finger protein GLIS1 *ENSGALG0000001072113
GLIS2 / GLIS family zinc finger 2 / Q8VDL9* / Q9BZE0* / Zinc finger protein GLIS2 *ENSGALG000000347379
ZIC1 / zinc finger protein ZIC 1 ENSGALG000000405329
ZIC2 / Zic family member 2 / O95409* / zinc finger protein of the cerebellum 2*ENSGALG000000410839
ZIC3 / Zic family member 3 / O60481* / Q62521* / zinc finger protein of the cerebellum 3*ENSGALG000000311448
ZIC4 / Zic family member 4 / Q61467* / Q8N9L1* / zinc finger protein of the cerebellum 4*ENSGALG000000068108
ZIC5 / Zic family member 5 / Q96T25* / zinc finger protein of the cerebellum 5*ENSGALG000000341977


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0002009 morphogenesis of an epithelium IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0002076 osteoblast development IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007418 ventral midline development IEA
 biological_processGO:0007442 hindgut morphogenesis IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008589 regulation of smoothened signaling pathway IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IEA
 biological_processGO:0009954 proximal/distal pattern formation IEA
 biological_processGO:0021508 floor plate formation IEA
 biological_processGO:0021513 spinal cord dorsal/ventral patterning IEA
 biological_processGO:0021517 ventral spinal cord development IEA
 biological_processGO:0021522 spinal cord motor neuron differentiation IEA
 biological_processGO:0021696 cerebellar cortex morphogenesis IEA
 biological_processGO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification IEA
 biological_processGO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification IEA
 biological_processGO:0021904 dorsal/ventral neural tube patterning IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IEA
 biological_processGO:0021965 spinal cord ventral commissure morphogenesis IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0030902 hindbrain development IEA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IEA
 biological_processGO:0035295 tube development IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048566 embryonic digestive tract development IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0048856 anatomical structure development IEA
 biological_processGO:0060032 notochord regression IEA
 biological_processGO:0060322 head development IEA
 biological_processGO:0060513 prostatic bud formation IEA
 biological_processGO:0060603 mammary gland duct morphogenesis IEA
 biological_processGO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0090103 cochlea morphogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0097542 ciliary tip IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
Hedgehog off state
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005108 CUL3 / cullin 3 / Q13618* / Q9JLV5*  / complex / reaction
 ENSGALG00000008096 SUFU / SUFU negative regulator of hedgehog signaling / Q9UMX1* / Q9Z0P7*  / reaction / complex
 ENSGALG00000009939 SPOP / speckle type BTB/POZ protein / Gm5286* / Gm5773* / Gm9117* / Gm9125* / Tdpoz5* / Gm4778* / Gm4858* / O43791* / P0DMR5* / P0DMR6* / Q6YCH2* / Q6ZWS8* / Q717B2* / Q717B4* / Tdpoz1* / T...  / complex / reaction
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSGALG00000002469 CDC73 / Q5ZLM0 / Parafibromin / Q6P1J9* / Q8JZM7* / cell division cycle 73*  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000032215 ULK3 / unc-51 like kinase 3 / Q3U3Q1* / Q6PHR2*  / reaction






 

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