ENSGALG00000008096


Gallus gallus

Features
Gene ID: ENSGALG00000008096
  
Biological name :SUFU
  
Synonyms : SUFU / SUFU negative regulator of hedgehog signaling
  
Possible biological names infered from orthology : Q9UMX1 / Q9Z0P7
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 23183999
Gene end: 23265004
  
Corresponding Affymetrix probe sets: Gga.18181.1.S1_at (Chicken Array)   Gga.2771.1.S1_at (Chicken Array)   Gga.2771.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053949
Ensembl peptide - ENSGALP00000013127
NCBI entrez gene - 374118     See in Manteia.
RefSeq - XM_015288541
RefSeq - NM_204264
RefSeq Peptide - NP_989595
swissprot - Q8QG94
swissprot - A0A1D5PM76
Ensembl - ENSGALG00000008096
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sufuENSDARG00000056801Danio rerio
 SUFUENSG00000107882Homo sapiens
 SufuENSMUSG00000025231Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007768  Suppressor of fused
 IPR016591  Suppressor of fused, eukaryotic
 IPR020941  Suppressor of fused-like domain
 IPR024314  Suppressor of fused C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0003281 ventricular septum development IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0021513 spinal cord dorsal/ventral patterning IEA
 biological_processGO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification IEA
 biological_processGO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification IEA
 biological_processGO:0035904 aorta development IEA
 biological_processGO:0042994 cytoplasmic sequestering of transcription factor IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IBA
 biological_processGO:0043588 skin development IEA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IEA
 biological_processGO:0060976 coronary vasculature development IEA
 biological_processGO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning IEA
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005929 cilium IEA
 molecular_functionGO:0003714 transcription corepressor activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog off state
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001364 P67962 / CSNK1A1 / Casein kinase I isoform alpha / Q8N752* / P48729* / Q8BK63* / CSNK1A1L* / casein kinase 1 alpha 1* / casein kinase 1 alpha 1 like*  / reaction
 ENSGALG00000040474 ITCH / itchy E3 ubiquitin protein ligase / Q8C863* / Q96J02* / E3 ubiquitin-protein ligase Itchy *  / complex / reaction
 ENSGALG00000040266 GLI3 / GLI family zinc finger 3 / P10071* / Q61602* / Transcriptional activator GLI3 Transcriptional repressor GLI3R*  / complex / reaction
 ENSGALG00000032215 ULK3 / unc-51 like kinase 3 / Q3U3Q1* / Q6PHR2*  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000011630 GLI2 / GLI family zinc finger 2 / P10070* / Q0VGT2* / Zinc finger protein GLI2 *  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr