ENSGALG00000040266


Gallus gallus

Features
Gene ID: ENSGALG00000040266
  
Biological name :GLI3
  
Synonyms : GLI3 / GLI family zinc finger 3
  
Possible biological names infered from orthology : P10071 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 50875914
Gene end: 51069730
  
Corresponding Affymetrix probe sets: Gga.3297.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048561
NCBI entrez gene - 420769     See in Manteia.
RefSeq - XM_015281561
RefSeq - NM_001271903
RefSeq - XM_015281557
RefSeq - XM_015281558
RefSeq - XM_015281556
RefSeq Peptide - NP_001258832
swissprot - A0A1D5P775
Ensembl - ENSGALG00000040266
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GLI3ENSG00000106571Homo sapiens
 Gli3ENSMUSG00000021318Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GLI2 / GLI family zinc finger 2 / P10070* / Q0VGT2* / Zinc finger protein GLI2 *ENSGALG0000001163046
GLIS3 / GLIS family zinc finger 3 / Q6XP49* / Q8NEA6* / Zinc finger protein GLIS3 *ENSGALG0000001018014
GLIS1 / GLIS family zinc finger 1 / Q8K1M4* / Q8NBF1* / Zinc finger protein GLIS1 *ENSGALG0000001072112
ZIC2 / Zic family member 2 / O95409* / zinc finger protein of the cerebellum 2*ENSGALG000000410839
ZIC3 / Zic family member 3 / O60481* / Q62521* / zinc finger protein of the cerebellum 3*ENSGALG000000311449
ZIC1 / zinc finger protein ZIC 1 ENSGALG000000405329
ZIC4 / Zic family member 4 / Q61467* / Q8N9L1* / zinc finger protein of the cerebellum 4*ENSGALG000000068108
GLIS2 / GLIS family zinc finger 2 / Q8VDL9* / Q9BZE0* / Zinc finger protein GLIS2 *ENSGALG000000347378
ZIC5 / Zic family member 5 / Q96T25* / zinc finger protein of the cerebellum 5*ENSGALG000000341976


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR032851  Transcription factor GLI3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0002052 positive regulation of neuroblast proliferation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007442 hindgut morphogenesis IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IEA
 biological_processGO:0009954 proximal/distal pattern formation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0021513 spinal cord dorsal/ventral patterning IEA
 biological_processGO:0021522 spinal cord motor neuron differentiation IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0021543 pallium development IEA
 biological_processGO:0021544 subpallium development IEA
 biological_processGO:0021631 optic nerve morphogenesis IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification IEA
 biological_processGO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification IEA
 biological_processGO:0021798 forebrain dorsal/ventral pattern formation IEA
 biological_processGO:0021801 cerebral cortex radial glia guided migration IEA
 biological_processGO:0021819 layer formation in cerebral cortex IEA
 biological_processGO:0021861 forebrain radial glial cell differentiation IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0022018 lateral ganglionic eminence cell proliferation IEA
 biological_processGO:0030318 melanocyte differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0035108 limb morphogenesis IEA
 biological_processGO:0035295 tube development IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043586 tongue development IEA
 biological_processGO:0045060 negative thymic T cell selection IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IEA
 biological_processGO:0046639 negative regulation of alpha-beta T cell differentiation IEA
 biological_processGO:0048557 embryonic digestive tract morphogenesis IEA
 biological_processGO:0048566 embryonic digestive tract development IEA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0048598 embryonic morphogenesis IEA
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IEA
 biological_processGO:0048663 neuron fate commitment IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0048856 anatomical structure development IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060173 limb development IEA
 biological_processGO:0060364 frontal suture morphogenesis IEA
 biological_processGO:0060366 lambdoid suture morphogenesis IEA
 biological_processGO:0060367 sagittal suture morphogenesis IEA
 biological_processGO:0060594 mammary gland specification IEA
 biological_processGO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning IEA
 biological_processGO:0060840 artery development IEA
 biological_processGO:0060873 anterior semicircular canal development IEA
 biological_processGO:0060875 lateral semicircular canal development IEA
 biological_processGO:0061005 cell differentiation involved in kidney development IEA
 biological_processGO:0070242 thymocyte apoptotic process IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1903010 regulation of bone development IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0016592 mediator complex IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
GLI3 is processed to GLI3R by the proteasome
Hedgehog off state
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001364 P67962 / CSNK1A1 / Casein kinase I isoform alpha / Q8N752* / P48729* / Q8BK63* / CSNK1A1L* / casein kinase 1 alpha 1* / casein kinase 1 alpha 1 like*  / reaction
 ENSGALG00000005108 CUL3 / cullin 3 / Q13618* / Q9JLV5*  / complex / reaction
 ENSGALG00000008096 SUFU / SUFU negative regulator of hedgehog signaling / Q9UMX1* / Q9Z0P7*  / reaction / complex
 ENSGALG00000009939 SPOP / speckle type BTB/POZ protein / Gm5286* / Gm5773* / Gm9117* / Gm9125* / Tdpoz5* / Gm4778* / Gm4858* / O43791* / P0DMR5* / P0DMR6* / Q6YCH2* / Q6ZWS8* / Q717B2* / Q717B4* / Tdpoz1* / T...  / complex / reaction
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSGALG00000032215 ULK3 / unc-51 like kinase 3 / Q3U3Q1* / Q6PHR2*  / reaction
 ENSGALG00000002469 CDC73 / Q5ZLM0 / Parafibromin / Q6P1J9* / Q8JZM7* / cell division cycle 73*  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr