ENSDARG00000056801


Danio rerio

Features
Gene ID: ENSDARG00000056801
  
Biological name :sufu
  
Synonyms : sufu / suppressor of fused homolog (Drosophila)
  
Possible biological names infered from orthology : Q9UMX1 / Q9Z0P7 / SUFU negative regulator of hedgehog signaling
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 11828516
Gene end: 11872143
  
Corresponding Affymetrix probe sets: Dr.6399.1.S1_at (Zebrafish Array)   NM_201309_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000131692
Ensembl peptide - ENSDARP00000136805
Ensembl peptide - ENSDARP00000136012
Ensembl peptide - ENSDARP00000133214
NCBI entrez gene - 100001615     See in Manteia.
RefSeq - NM_201309
RefSeq Peptide - NP_958466
swissprot - A9JRW8
swissprot - A0A0R4IN62
swissprot - A0A0R4IFN6
ZFIN ID - ZDB-GENE-030131-6223
Ensembl - ENSDARG00000056801
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SUFUENSGALG00000008096Gallus gallus
 SUFUENSG00000107882Homo sapiens
 SufuENSMUSG00000025231Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007768  Suppressor of fused
 IPR016591  Suppressor of fused, eukaryotic
 IPR020941  Suppressor of fused-like domain
 IPR024314  Suppressor of fused C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0007224 smoothened signaling pathway IGI
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0033333 fin development IMP
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0035301 Hedgehog signaling complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Degradation of GLI1 by the proteasome
Hedgehog off state
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens quality , abnormal
lens decreased size , abnormal
lens elliptic , abnormal
lens degenerate , abnormal
lens morphology , abnormal
Show

 ZFA:0000040 median fin fold median fin fold epithelium undulate , abnormal
median fin fold increased size , abnormal
median fin fold undulate , abnormal
Show

 ZFA:0000155 somite somite shape , abnormal
somite obtuse angle to somite , abnormal
Show

 ZFA:0000217 inner ear inner ear quality , abnormal
inner ear decreased size , abnormal
inner ear structure , abnormal
inner ear morphology , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0001056 myotome myotome increased distribution , abnormal
Show

 ZFA:0001069 ventral fin fold ventral fin fold epithelium undulate , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased size , abnormal
whole organism sterile , abnormal
whole organism dwarf-like , abnormal
Show

 ZFA:0001114 head head increased volume , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin increased size , abnormal
pectoral fin folded , abnormal
pectoral fin undulate , abnormal
Show

 ZFA:0001162 anal fin anal fin aplastic , abnormal
anal fin absent , abnormal
Show

 ZFA:0001283 pupil pupil size , abnormal
pupil decreased size , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage physical object quality , abnormal
ceratohyal cartilage ossified , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage physical object quality , abnormal
hyosymplectic cartilage ossified , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 chondrocyte irregular spatial pattern , abnormal
Show

 ZFA:0001672 dorsolateral septum dorsolateral septum aplastic , abnormal
Show

 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell decreased amount , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell increased amount , abnormal
slow muscle cell disorganized , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell increased amount , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
Show

 ZFA:0009323 thrombocyte thrombocyte decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000074903 itcha / itchy E3 ubiquitin protein ligase a / ITCH* / Q8C863* / Q96J02* / itchy E3 ubiquitin protein ligase* / E3 ubiquitin-protein ligase Itchy *  / complex
 ENSDARG00000099199 itchb / itchy E3 ubiquitin protein ligase b / ITCH* / Q96J02* / itchy E3 ubiquitin protein ligase*  / complex






 

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