ENSDARG00000099199


Danio rerio

Features
Gene ID: ENSDARG00000099199
  
Biological name :itchb
  
Synonyms : itchb / itchy E3 ubiquitin protein ligase b
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase Itchy / ITCH / itchy E3 ubiquitin protein ligase / Q8C863 / Q96J02
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 43535224
Gene end: 43595956
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000130100
swissprot - A0A0R4IBD8
ZFIN ID - ZDB-GENE-131024-2
Ensembl - ENSDARG00000099199
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ITCHENSGALG00000040474Gallus gallus
 ITCHENSG00000078747Homo sapiens
 ItchENSMUSG00000027598Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
itcha / itchy E3 ubiquitin protein ligase a / ITCH* / Q8C863* / Q96J02* / itchy E3 ubiquitin protein ligase* / E3 ubiquitin-protein ligase Itchy *ENSDARG0000007490379
wwp1 / WW domain containing E3 ubiquitin protein ligase 1 / Q8BZZ3* / Q9H0M0*ENSDARG0000009753756
wwp2 / WW domain containing E3 ubiquitin protein ligase 2 / O00308* / Q9DBH0*ENSDARG0000006134554
nedd4l / neural precursor cell expressed, developmentally down-regulated 4-like / Q96PU5* / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase*ENSDARG0000006000636
A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *ENSDARG0000003806734
hecw1b / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b / HECW1* / Q8K4P8* / Q76N89* / E3 ubiquitin-protein ligase HECW1 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000000429132
smurf1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *ENSDARG0000001608632
hecw2a / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a / HECW2* / Q9P2P5* / Q6I6G8* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000006244731
si:ch211-188f17.1 / HECW1* / Q76N89* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1*ENSDARG0000010095829
nedd4a / neural precursor cell expressed, developmentally down-regulated 4a / NEDD4* / P46934* / P46935* / neural precursor cell expressed, developmentally down-regulated 4* / neural precur...ENSDARG0000009984329
hace1 / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 / Q8IYU2*ENSDARG0000006228024
hecw2b / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b / HECW2* / Q9P2P5* / Q6I6G8* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000006325312
LO018629.1 / HECW2* / Q6I6G8* / Q9P2P5* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2*ENSDARG000001138482


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR024928  E3 ubiquitin-protein ligase, SMURF1 type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0048920 posterior lateral line neuromast primordium migration IMP
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Downregulation of ERBB4 signaling
NOD1/2 Signaling Pathway
Activated NOTCH1 Transmits Signal to the Nucleus
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000056801 sufu / suppressor of fused homolog (Drosophila) / Q9UMX1* / Q9Z0P7* / SUFU negative regulator of hedgehog signaling*  / complex






 

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