Manteia

ENSDARG00000061345

Danio rerio

Features

Gene ID:	ENSDARG00000061345

Biological name :	wwp2

Synonyms :	WW domain containing E3 ubiquitin protein ligase 2 / wwp2

Possible biological names infered from orthology :	O00308 / Q9DBH0

Species:	Danio rerio

Chr. number:	25
Strand:	1
Band:
Gene start:	34748125
Gene end:	34805144

Corresponding Affymetrix probe sets:	Dr.25779.1.A1_at (Zebrafish Array) Dr.3154.1.A1_at (Zebrafish Array)

Cross references:	Ensembl peptide - ENSDARP00000112571 Ensembl peptide - ENSDARP00000154551 Ensembl peptide - ENSDARP00000122529 Ensembl peptide - ENSDARP00000117944 Ensembl peptide - ENSDARP00000081798 NCBI entrez gene - 564527 See in Manteia. RefSeq - XM_005163171 RefSeq - XM_005163173 RefSeq - XM_017354087 RefSeq - NM_001099448 RefSeq Peptide - NP_001092918 swissprot - E9QGN8 swissprot - E9QDH5 swissprot - A2VCZ7 swissprot - F6P346 ZFIN ID - ZDB-GENE-000607-82 Ensembl - ENSDARG00000061345

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
WWP2	ENSGALG00000000699	Gallus gallus
WWP2	ENSG00000198373	Homo sapiens
Wwp2	ENSMUSG00000031930	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
wwp1 / WW domain containing E3 ubiquitin protein ligase 1 / Q8BZZ3* / Q9H0M0*	ENSDARG00000097537	59
itcha / itchy E3 ubiquitin protein ligase a / ITCH* / Q8C863* / Q96J02* / itchy E3 ubiquitin protein ligase* / E3 ubiquitin-protein ligase Itchy *	ENSDARG00000074903	55
itchb / itchy E3 ubiquitin protein ligase b / ITCH* / Q96J02* / itchy E3 ubiquitin protein ligase*	ENSDARG00000099199	53
nedd4l / neural precursor cell expressed, developmentally down-regulated 4-like / Q96PU5* / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase*	ENSDARG00000060006	37
A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *	ENSDARG00000038067	33
hecw1b / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b / HECW1* / Q8K4P8* / Q76N89* / E3 ubiquitin-protein ligase HECW1 * / HECT, C2 and WW domain containing E3 ubiquitin...	ENSDARG00000004291	32
smurf1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *	ENSDARG00000016086	32
hecw2a / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a / HECW2* / Q9P2P5* / Q6I6G8* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin...	ENSDARG00000062447	30
si:ch211-188f17.1 / HECW1* / Q76N89* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1*	ENSDARG00000100958	29
nedd4a / neural precursor cell expressed, developmentally down-regulated 4a / NEDD4* / P46934* / P46935* / neural precursor cell expressed, developmentally down-regulated 4* / neural precur...	ENSDARG00000099843	27
hace1 / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 / Q8IYU2*	ENSDARG00000062280	23
hecw2b / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b / HECW2* / Q9P2P5* / Q6I6G8* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin...	ENSDARG00000063253	13
LO018629.1 / HECW2* / Q6I6G8* / Q9P2P5* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2*	ENSDARG00000113848	1

Protein motifs (from Interpro)

Interpro ID	Name
IPR000008	C2 domain
IPR000569	HECT domain
IPR001202	WW domain
IPR024928	E3 ubiquitin-protein ligase, SMURF1 type

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	IEA
biological_process	GO:0016567	protein ubiquitination	IEA
biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
biological_process	GO:0060021	roof of mouth development	IMP
cellular_component	GO:0005634	nucleus	ISS
cellular_component	GO:0005737	cytoplasm	IBA
molecular_function	GO:0004842	ubiquitin-protein transferase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016874	ligase activity	IEA
molecular_function	GO:0061630	ubiquitin protein ligase activity	IEA

Pathways (from Reactome)

Pathway description

Regulation of PTEN stability and activity

NOTCH3 Activation and Transmission of Signal to the Nucleus

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0005509	palate	palate decreased size , abnormal palate fused with palate , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr