ENSDARG00000062280


Danio rerio

Features
Gene ID: ENSDARG00000062280
  
Biological name :hace1
  
Synonyms : hace1 / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase HACE1 / Q3U0D9 / Q8IYU2
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 2351520
Gene end: 2390931
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000124679
NCBI entrez gene - 572430     See in Manteia.
swissprot - K7DY07
ZFIN ID - ZDB-GENE-110411-52
Ensembl - ENSDARG00000062280
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HACE1ENSGALG00000015415Gallus gallus
 HACE1ENSG00000085382Homo sapiens
 Hace1ENSMUSG00000038822Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nedd4l / neural precursor cell expressed, developmentally down-regulated 4-like / Q96PU5* / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase*ENSDARG0000006000625
hecw1b / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b / HECW1* / Q8K4P8* / Q76N89* / E3 ubiquitin-protein ligase HECW1 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000000429124
si:ch211-188f17.1 / HECW1* / Q76N89* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1*ENSDARG0000010095823
itcha / itchy E3 ubiquitin protein ligase a / ITCH* / Q8C863* / Q96J02* / itchy E3 ubiquitin protein ligase* / E3 ubiquitin-protein ligase Itchy *ENSDARG0000007490323
hecw2a / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a / HECW2* / Q9P2P5* / Q6I6G8* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000006244723
A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *ENSDARG0000003806723
wwp1 / WW domain containing E3 ubiquitin protein ligase 1 / Q8BZZ3* / Q9H0M0*ENSDARG0000009753723
smurf1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *ENSDARG0000001608622
wwp2 / WW domain containing E3 ubiquitin protein ligase 2 / O00308* / Q9DBH0*ENSDARG0000006134522
itchb / itchy E3 ubiquitin protein ligase b / ITCH* / Q96J02* / itchy E3 ubiquitin protein ligase*ENSDARG0000009919922
nedd4a / neural precursor cell expressed, developmentally down-regulated 4a / NEDD4* / P46934* / P46935* / neural precursor cell expressed, developmentally down-regulated 4* / neural precur...ENSDARG0000009984319
hecw2b / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b / HECW2* / Q9P2P5* / Q6I6G8* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000006325311
LO018629.1 / HECW2* / Q6I6G8* / Q9P2P5* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2*ENSDARG000001138482


Protein motifs (from Interpro)
Interpro ID Name
 IPR000569  HECT domain
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle decreased thickness , abnormal
cardiac ventricle elongated , abnormal
Show

 ZFA:0000114 heart heart decreased amount , abnormal
heart tubular , abnormal
heart morphology , abnormal
heart inverted , abnormal
heart reactive oxygen species increased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism reactive oxygen species increased amount , abnormal
whole organism reactive oxygen species amount , ameliorated
Show

 ZFA:0001315 atrioventricular canal atrioventricular canal morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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