ENSDARG00000060006


Danio rerio

Features
Gene ID: ENSDARG00000060006
  
Biological name :nedd4l
  
Synonyms : nedd4l / neural precursor cell expressed, developmentally down-regulated 4-like
  
Possible biological names infered from orthology : neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase / Q96PU5
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 10890258
Gene end: 11054876
  
Corresponding Affymetrix probe sets: Dr.26164.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000078496
Ensembl peptide - ENSDARP00000117300
Ensembl peptide - ENSDARP00000153459
swissprot - F1Q632
swissprot - F1QP93
ZFIN ID - ZDB-GENE-051118-2
Ensembl - ENSDARG00000060006
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000034584Gallus gallus
 ENSGALG00000031355Gallus gallus
 NEDD4LENSG00000049759Homo sapiens
 Nedd4lENSMUSG00000024589Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nedd4a / neural precursor cell expressed, developmentally down-regulated 4a / NEDD4* / P46934* / P46935* / neural precursor cell expressed, developmentally down-regulated 4* / neural precur...ENSDARG0000009984349
wwp2 / WW domain containing E3 ubiquitin protein ligase 2 / O00308* / Q9DBH0*ENSDARG0000006134532
itcha / itchy E3 ubiquitin protein ligase a / ITCH* / Q8C863* / Q96J02* / itchy E3 ubiquitin protein ligase* / E3 ubiquitin-protein ligase Itchy *ENSDARG0000007490331
hecw1b / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b / HECW1* / Q8K4P8* / Q76N89* / E3 ubiquitin-protein ligase HECW1 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000000429130
wwp1 / WW domain containing E3 ubiquitin protein ligase 1 / Q8BZZ3* / Q9H0M0*ENSDARG0000009753730
itchb / itchy E3 ubiquitin protein ligase b / ITCH* / Q96J02* / itchy E3 ubiquitin protein ligase*ENSDARG0000009919930
hecw2a / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a / HECW2* / Q9P2P5* / Q6I6G8* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000006244729
A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *ENSDARG0000003806729
smurf1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *ENSDARG0000001608628
si:ch211-188f17.1 / HECW1* / Q76N89* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1*ENSDARG0000010095827
hace1 / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 / Q8IYU2*ENSDARG0000006228022
hecw2b / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b / HECW2* / Q9P2P5* / Q6I6G8* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000006325311
LO018629.1 / HECW2* / Q6I6G8* / Q9P2P5* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2*ENSDARG000001138482


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR024928  E3 ubiquitin-protein ligase, SMURF1 type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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