ENSDARG00000004291


Danio rerio

Features
Gene ID: ENSDARG00000004291
  
Biological name :hecw1b
  
Synonyms : HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b / hecw1b
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase HECW1 / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 / HECW1 / Q76N89 / Q8K4P8
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 49884696
Gene end: 49978227
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000116253
NCBI entrez gene - 563730     See in Manteia.
RefSeq - NM_001145764
RefSeq Peptide - NP_001139236
swissprot - Q1LYI3
ZFIN ID - ZDB-GENE-060503-2
Ensembl - ENSDARG00000004291
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HECW1ENSGALG00000037193Gallus gallus
 HECW1ENSG00000002746Homo sapiens
 Hecw1ENSMUSG00000021301Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:ch211-188f17.1 / HECW1* / Q76N89* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1*ENSDARG0000010095861
hecw2a / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a / HECW2* / Q9P2P5* / Q6I6G8* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000006244751
nedd4l / neural precursor cell expressed, developmentally down-regulated 4-like / Q96PU5* / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase*ENSDARG0000006000619
itcha / itchy E3 ubiquitin protein ligase a / ITCH* / Q8C863* / Q96J02* / itchy E3 ubiquitin protein ligase* / E3 ubiquitin-protein ligase Itchy *ENSDARG0000007490319
wwp2 / WW domain containing E3 ubiquitin protein ligase 2 / O00308* / Q9DBH0*ENSDARG0000006134518
A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *ENSDARG0000003806717
smurf1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *ENSDARG0000001608617
itchb / itchy E3 ubiquitin protein ligase b / ITCH* / Q96J02* / itchy E3 ubiquitin protein ligase*ENSDARG0000009919917
wwp1 / WW domain containing E3 ubiquitin protein ligase 1 / Q8BZZ3* / Q9H0M0*ENSDARG0000009753717
nedd4a / neural precursor cell expressed, developmentally down-regulated 4a / NEDD4* / P46934* / P46935* / neural precursor cell expressed, developmentally down-regulated 4* / neural precur...ENSDARG0000009984315
hace1 / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 / Q8IYU2*ENSDARG0000006228014
hecw2b / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b / HECW2* / Q9P2P5* / Q6I6G8* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000006325313
LO018629.1 / HECW2* / Q6I6G8* / Q9P2P5* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2*ENSDARG000001138489


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR032348  E3 ubiquitin-protein ligase HECW1/2, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Degradation of DVL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010515 dvl1a / dishevelled segment polarity protein 1a / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*  / complex / reaction
 ENSDARG00000055552 dvl1b / dishevelled segment polarity protein 1b / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*  / reaction / complex






 

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