ENSDARG00000055552


Danio rerio

Features
Gene ID: ENSDARG00000055552
  
Biological name :dvl1b
  
Synonyms : dishevelled segment polarity protein 1b / dvl1b
  
Possible biological names infered from orthology : dishevelled segment polarity protein 1 / DVL1 / O14640 / P51141 / Segment polarity DVL-1
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 24360744
Gene end: 24428319
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000094527
Ensembl peptide - ENSDARP00000156001
NCBI entrez gene - 560032     See in Manteia.
RefSeq - NM_001044917
RefSeq Peptide - NP_001038382
swissprot - F1QNA4
ZFIN ID - ZDB-GENE-071004-1
Ensembl - ENSDARG00000055552
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DVL1ENSGALG00000001600Gallus gallus
 DVL1ENSG00000107404Homo sapiens
 Dvl1ENSMUSG00000029071Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dvl1a / dishevelled segment polarity protein 1a / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*ENSDARG0000001051562
dvl3b / dishevelled segment polarity protein 3bENSDARG0000010346261
dvl2 / dishevelled segment polarity protein 2 / O14641* / Q60838* / Segment polarity DVL-2 *ENSDARG0000005618458
dvl3a / dishevelled segment polarity protein 3aENSDARG0000001570755
si:ch73-236e11.2 / DVL1* / O14640* / P51141* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*ENSDARG0000009591915
dixdc1b / DIX domain containing 1b / Q80Y83* / Dixin * / DIXDC1* / Q155Q3* / DIX domain containing 1*ENSDARG0000005626711
dixdc1a / DIX domain containing 1a / Q80Y83* / Dixin * / DIXDC1* / Q155Q3* / DIX domain containing 1*ENSDARG000000253027


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR001158  DIX domain
 IPR001478  PDZ domain
 IPR003351  Dishevelled protein domain
 IPR008339  Dishevelled family
 IPR008340  Dishevelled-1
 IPR011991  ArsR-like helix-turn-helix domain
 IPR015506  Dishevelled-related protein
 IPR024580  Dishevelled C-terminal
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IBA
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IBA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0005109 frizzled binding IBA


Pathways (from Reactome)
Pathway description
WNT mediated activation of DVL
PCP/CE pathway
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism has extra parts of type post-vent region , abnormal
Show

 ZFA:0001117 post-vent region post-vent region deformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006508 pip5k1bb / phosphatidylinositol-4-phosphate 5-kinase, type I, beta b / O14986* / P70181* / PIP5K1B* / phosphatidylinositol-4-phosphate 5-kinase type 1 beta*  / reaction / complex
 ENSDARG00000055554 wnt1 / P24257 / wingless-type MMTV integration site family, member 1 / P04628* / P04426* / Wnt family member 1*  / complex
 ENSDARG00000045150 csnk1e / casein kinase 1, epsilon / P49674* / Q9JMK2* / Z98749.3* / Casein kinase I isoform epsilon *  / reaction
 ENSDARG00000044295 pip5k1ba / phosphatidylinositol-4-phosphate 5-kinase, type I, beta a / O14986* / P70181* / PIP5K1B* / phosphatidylinositol-4-phosphate 5-kinase type 1 beta*  / reaction / complex
 ENSDARG00000102964 axin1 / O15169*  / complex / reaction
 ENSDARG00000052468 si:dkeyp-80c12.7 / GSK3B (1 of many) / GSK3B* / P49841* / Q9WV60* / glycogen synthase kinase 3 beta*  / reaction / complex
 ENSDARG00000017803 gsk3b / glycogen synthase kinase 3 beta / P49841* / Q9WV60*  / reaction / complex
 ENSDARG00000004291 hecw1b / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b / HECW1* / Q8K4P8* / Q76N89* / E3 ubiquitin-protein ligase HECW1 * / HECT, C2 and WW domain containing E3 ubiquitin...  / complex / reaction
 ENSDARG00000106062 fzd1 / frizzled class receptor 1 / Q9UP38*  / complex






 

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