ENSGALG00000001600


Gallus gallus

Features
Gene ID: ENSGALG00000001600
  
Biological name :DVL1
  
Synonyms : dishevelled segment polarity protein 1 / DVL1
  
Possible biological names infered from orthology : O14640 / P51141 / Segment polarity DVL-1
  
Species: Gallus gallus
  
Chr. number: 21
Strand: 1
Band:
Gene start: 2268370
Gene end: 2322090
  
Corresponding Affymetrix probe sets: Gga.16412.1.S1_s_at (Chicken Array)   GgaAffx.1037.1.S1_at (Chicken Array)   GgaAffx.20672.1.S1_at (Chicken Array)   GgaAffx.20935.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002423
NCBI entrez gene - 419416     See in Manteia.
RefSeq - XM_015297118
RefSeq - XM_015297119
RefSeq - XM_015297120
swissprot - F6T4S2
Ensembl - ENSGALG00000001600
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dvl1aENSDARG00000010515Danio rerio
 dvl1bENSDARG00000055552Danio rerio
 si:ch73-236e11.2ENSDARG00000095919Danio rerio
 DVL1ENSG00000107404Homo sapiens
 Dvl1ENSMUSG00000029071Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DVL3 / dishevelled segment polarity protein 3 / Q61062* / Q92997* / Segment polarity DVL-3 *ENSGALG0000000841471
DIXDC1 / DIX domain containing 1 / Dixin * / Q155Q3* / Q80Y83*ENSGALG0000000792911


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR001158  DIX domain
 IPR001478  PDZ domain
 IPR003351  Dishevelled protein domain
 IPR008339  Dishevelled family
 IPR008340  Dishevelled-1
 IPR011991  ArsR-like helix-turn-helix domain
 IPR015506  Dishevelled-related protein
 IPR024580  Dishevelled C-terminal
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001505 regulation of neurotransmitter levels IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007269 neurotransmitter secretion IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007528 neuromuscular junction development IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0022007 convergent extension involved in neural plate elongation IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0031122 cytoplasmic microtubule organization IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035372 protein localization to microtubule IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043113 receptor clustering IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048668 collateral sprouting IEA
 biological_processGO:0048675 axon extension IEA
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0060029 convergent extension involved in organogenesis IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IEA
 biological_processGO:0060134 prepulse inhibition IEA
 biological_processGO:0071340 skeletal muscle acetylcholine-gated channel clustering IEA
 biological_processGO:0090103 cochlea morphogenesis IEA
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1903827 regulation of cellular protein localization IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:1990909 Wnt signalosome IEA
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
WNT mediated activation of DVL
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000029402 AXIN1 / O15169*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000042657 WNT3A / Q2LMP1 / Protein Wnt-3a / P56704* / P27467* / Wnt family member 3A* / wingless-type MMTV integration site family, member 3A*  / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000015107 PIP5K1B / phosphatidylinositol 4-phosphate 5-kinase type-1 beta / O14986* / P70181*  / reaction / complex
 ENSGALG00000031503 LRP6 / LDL receptor related protein 6 / O75581*  / complex
 ENSGALG00000032257 CSNK1E / Q5ZLL1 / Casein kinase I isoform epsilon / Q9JMK2* / P49674* / Z98749.3* / casein kinase 1 epsilon*  / reaction






 

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