ENSMUSG00000029071


Mus musculus

Features
Gene ID: ENSMUSG00000029071
  
Biological name :Dvl1
  
Synonyms : Dvl1 / P51141 / Segment polarity DVL-1
  
Possible biological names infered from orthology : dishevelled segment polarity protein 1 / O14640
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 155847402
Gene end: 155859303
  
Corresponding Affymetrix probe sets: 10511190 (MoGene1.0st)   1437301_a_at (Mouse Genome 430 2.0 Array)   1450978_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030948
Ensembl peptide - ENSMUSP00000133137
NCBI entrez gene - 13542     See in Manteia.
MGI - MGI:94941
RefSeq - XM_017319952
RefSeq - NM_001302342
RefSeq - NM_010091
RefSeq - XM_006538521
RefSeq - XM_006538522
RefSeq - XM_006538523
RefSeq - XM_006538518
RefSeq - XM_006538519
RefSeq - XM_006538520
RefSeq Peptide - NP_034221
RefSeq Peptide - NP_001289271
swissprot - P51141
Ensembl - ENSMUSG00000029071
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dvl1aENSDARG00000010515Danio rerio
 dvl1bENSDARG00000055552Danio rerio
 si:ch73-236e11.2ENSDARG00000095919Danio rerio
 DVL1ENSGALG00000001600Gallus gallus
 DVL1ENSG00000107404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*ENSMUSG0000000323367
Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*ENSMUSG0000002088861
Dixdc1 / Dixin / Q80Y83 / Q155Q3* / DIX domain containing 1*ENSMUSG0000003206413


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR001158  DIX domain
 IPR001478  PDZ domain
 IPR003351  Dishevelled protein domain
 IPR008339  Dishevelled family
 IPR008340  Dishevelled-1
 IPR015506  Dishevelled-related protein
 IPR024580  Dishevelled C-terminal
 IPR029071  Ubiquitin-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001505 regulation of neurotransmitter levels IMP
 biological_processGO:0001932 regulation of protein phosphorylation IGI
 biological_processGO:0001933 negative regulation of protein phosphorylation IGI
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0006366 transcription by RNA polymerase II ISO
 biological_processGO:0006469 negative regulation of protein kinase activity ISO
 biological_processGO:0007269 neurotransmitter secretion IGI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007409 axonogenesis IDA
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0007528 neuromuscular junction development IGI
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0016055 Wnt signaling pathway NAS
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0022007 convergent extension involved in neural plate elongation IGI
 biological_processGO:0030177 positive regulation of Wnt signaling pathway ISO
 biological_processGO:0031122 cytoplasmic microtubule organization IGI
 biological_processGO:0032091 negative regulation of protein binding ISO
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0034504 protein localization to nucleus ISO
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0035372 protein localization to microtubule IGI
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043113 receptor clustering IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0048668 collateral sprouting IDA
 biological_processGO:0048675 axon extension IDA
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0050808 synapse organization IMP
 biological_processGO:0050821 protein stabilization IGI
 biological_processGO:0060029 convergent extension involved in organogenesis IMP
 biological_processGO:0060070 canonical Wnt signaling pathway ISO
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway ISO
 biological_processGO:0060134 prepulse inhibition IMP
 biological_processGO:0060997 dendritic spine morphogenesis IEA
 biological_processGO:0071340 skeletal muscle acetylcholine-gated channel clustering IMP
 biological_processGO:0090103 cochlea morphogenesis IGI
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IGI
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0150012 positive regulation of neuron projection arborization IEA
 biological_processGO:1903827 regulation of cellular protein localization ISO
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0015630 microtubule cytoskeleton ISO
 cellular_componentGO:0016020 membrane NAS
 cellular_componentGO:0016328 lateral plasma membrane ISO
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone ISO
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0043005 neuron projection ISO
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:1990909 Wnt signalosome IDA
 molecular_functionGO:0005109 frizzled binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
WNT mediated activation of DVL
PCP/CE pathway
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Tg(Dvl2*/EGFP)4Awb/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001446 whisker trimming "biting of the whiskers or facial hair by cagemates" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001448 abnormal huddling behavior "deviation from the usual tendency of mice to pile together when sleeping" [What s wrong with my mouse?:ISBN 0-471-31639-3, J:42758]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2Lp
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Tg(Dvl2/EGFP)2Awb/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0002635 reduced sensorimotor gating 
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

 MP:0004407 increased cochlear hair cell number "increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Tg(Dvl2*K446M/EGFP)5Awb/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl1tm1Awb/Dvl1+,Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2Lp
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Tg(Dvl2*/EGFP)4Awb/?
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Tg(Dvl2*K446M/EGFP)5Awb/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Dvl1tm1Awb/Dvl1+,Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0012675 enlarged floor plate "increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [MGI:anna]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024867 P70181 / Pip5k1b / Phosphatidylinositol 4-phosphate 5-kinase type-1 beta / O14986*  / reaction / complex
 ENSMUSG00000024387 Csnk2b / P67871 / Casein kinase II subunit beta / P67870* / casein kinase 2 beta*  / reaction
 ENSMUSG00000044674 Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*  / complex
 ENSMUSG00000012282 Wnt8a / Q64527 / wingless-type MMTV integration site family, member 8A / Q9H1J5* / Wnt family member 8A*  / complex
 ENSMUSG00000022997 Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*  / complex
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / complex
 ENSMUSG00000009900 Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*  / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction / complex
 ENSMUSG00000036961 Wnt8b / wingless-type MMTV integration site family, member 8B / Q93098* / Wnt family member 8B*  / complex
 ENSMUSG00000024182 Axin1 / O15169*  / complex / reaction
 ENSMUSG00000050288 Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*  / complex
 ENSMUSG00000046707 O54833 / Csnk2a2 / Casein kinase II subunit alpha / P19784* / casein kinase 2 alpha 2*  / reaction
 ENSMUSG00000021301 Hecw1 / Q8K4P8 / E3 ubiquitin-protein ligase HECW1 / Q76N89* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1*  / reaction / complex
 ENSMUSG00000022433 Csnk1e / Q9JMK2 / Casein kinase I isoform epsilon / P49674* / Z98749.3* / casein kinase 1 epsilon*  / reaction
 ENSMUSG00000101523 Q60737 / Gm10031 / predicted pseudogene 10031 / Q8NEV1* / P68400* / CSNK2A1* / CSNK2A3* / casein kinase 2 alpha 1* / casein kinase 2 alpha 3*  / reaction






 

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