ENSMUSG00000024387


Mus musculus

Features
Gene ID: ENSMUSG00000024387
  
Biological name :Csnk2b
  
Synonyms : Casein kinase II subunit beta / Csnk2b / P67871
  
Possible biological names infered from orthology : casein kinase 2 beta / P67870
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 35116196
Gene end: 35122053
  
Corresponding Affymetrix probe sets: 10450435 (MoGene1.0st)   1416728_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025246
Ensembl peptide - ENSMUSP00000133684
Ensembl peptide - ENSMUSP00000134673
Ensembl peptide - ENSMUSP00000133425
Ensembl peptide - ENSMUSP00000134413
Ensembl peptide - ENSMUSP00000134218
Ensembl peptide - ENSMUSP00000133826
Ensembl peptide - ENSMUSP00000134523
NCBI entrez gene - 13001     See in Manteia.
MGI - MGI:88548
RefSeq - NM_001303446
RefSeq - NM_009975
RefSeq - NM_001303445
RefSeq - NM_001303476
RefSeq Peptide - NP_001290375
RefSeq Peptide - NP_001290374
RefSeq Peptide - NP_034105
RefSeq Peptide - NP_001290405
swissprot - P67871
swissprot - G3UWU5
swissprot - G3UXG7
swissprot - G3UXU2
swissprot - G3UZA4
swissprot - G3UZJ5
swissprot - G3UZX4
Ensembl - ENSMUSG00000024387
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csnk2bENSDARG00000077776Danio rerio
 CSNK2BENSG00000204435Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000704  Casein kinase II, regulatory subunit
 IPR016149  Casein kinase II, regulatory subunit, N-terminal
 IPR035991  Casein kinase II subunit beta-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0032927 positive regulation of activin receptor signaling pathway IEA
 biological_processGO:0033211 adiponectin-activated signaling pathway IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0061154 endothelial tube morphogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005956 protein kinase CK2 complex IEA
 cellular_componentGO:0031519 PcG protein complex IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019887 protein kinase regulator activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PC
WNT mediated activation of DVL
Condensation of Prometaphase Chromosomes
Signal transduction by L1
Neutrophil degranulation
Regulation of TP53 Activity through Phosphorylation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Receptor Mediated Mitophagy
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027067 Ssrp1 / Q08943 / FACT complex subunit SSRP1 / Q08945* / structure specific recognition protein 1*  / complex / reaction
 ENSMUSG00000025040 Fundc1 / Q9DB70 / FUN14 domain-containing protein 1 / Q8IVP5* / FUN14 domain containing 1*  / reaction
 ENSMUSG00000035726 Supt16 / suppressor of Ty 16 / Q9Y5B9* / SUPT16H* / SPT16 homolog, facilitates chromatin remodeling subunit*  / reaction / complex
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000013663 Pten / O08586 / phosphatase and tensin homolog / P60484*  / reaction
 ENSMUSG00000009030 Pdcl / Q9DBX2 / Phosducin-like protein / Q13371* / phosducin like*  / reaction
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / reaction
 ENSMUSG00000029071 Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*  / reaction
 ENSMUSG00000024387 Csnk2b / P67871 / Casein kinase II subunit beta / P67870* / casein kinase 2 beta*  / complex
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / reaction
 ENSMUSG00000030688 Q9JMD3 / Stard10 / START domain containing 10 / Q9Y365* / StAR related lipid transfer domain containing 10*  / reaction
 ENSMUSG00000046707 O54833 / Csnk2a2 / Casein kinase II subunit alpha / P19784* / casein kinase 2 alpha 2*  / complex
 ENSMUSG00000101523 Q60737 / Gm10031 / predicted pseudogene 10031 / Q8NEV1* / P68400* / CSNK2A1* / CSNK2A3* / casein kinase 2 alpha 1* / casein kinase 2 alpha 3*  / complex






 

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