ENSMUSG00000009030


Mus musculus

Features
Gene ID: ENSMUSG00000009030
  
Biological name :Pdcl
  
Synonyms : Pdcl / Phosducin-like protein / Q9DBX2
  
Possible biological names infered from orthology : phosducin like / Q13371
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 37350074
Gene end: 37359332
  
Corresponding Affymetrix probe sets: 10482139 (MoGene1.0st)   1423599_a_at (Mouse Genome 430 2.0 Array)   1425149_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108562
Ensembl peptide - ENSMUSP00000145483
Ensembl peptide - ENSMUSP00000119372
Ensembl peptide - ENSMUSP00000009174
NCBI entrez gene - 67466     See in Manteia.
MGI - MGI:1914716
RefSeq - NM_026176
RefSeq - XM_006498252
RefSeq Peptide - NP_080452
swissprot - A2AVP3
swissprot - Q9DBX2
swissprot - A0A0N4SWE2
Ensembl - ENSMUSG00000009030
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdclENSDARG00000009480Danio rerio
 PDCLENSGALG00000001275Gallus gallus
 PDCLENSG00000136940Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdc / Q9QW08 / Phosducin / P20941*ENSMUSG0000000600737


Protein motifs (from Interpro)
Interpro ID Name
 IPR001200  Phosducin
 IPR023196  Phosducin, N-terminal domain superfamily
 IPR024253  Phosducin, thioredoxin-like domain
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0008616 queuosine biosynthetic process IBA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IMP
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:1902605 heterotrimeric G-protein complex assembly IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0008479 queuine tRNA-ribosyltransferase activity IBA


Pathways (from Reactome)
Pathway description
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0001999 photosensitivity "alterations in the response to sunlight or UV irradiation, especially sensitivity of the eyes" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0003011 delayed dark adaptation "increase in time required for the eye to recover its sensitivity in the dark following exposure to bright lights" [J:68444, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0006149 blurred vision "loss of visiual acuity or ability to distinguish small details" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023439 Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*  / complex
 ENSMUSG00000024387 Csnk2b / P67871 / Casein kinase II subunit beta / P67870* / casein kinase 2 beta*  / reaction
 ENSMUSG00000029713 Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*  / complex
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / reaction / complex
 ENSMUSG00000046707 O54833 / Csnk2a2 / Casein kinase II subunit alpha / P19784* / casein kinase 2 alpha 2*  / reaction
 ENSMUSG00000032192 Gnb5 / P62881 / guanine nucleotide binding protein (G protein), beta 5 / O14775* / G protein subunit beta 5*  / complex
 ENSMUSG00000027669 Gnb4 / P29387 / guanine nucleotide binding protein (G protein), beta 4 / Q9HAV0* / G protein subunit beta 4*  / complex
 ENSMUSG00000101523 Q60737 / Gm10031 / predicted pseudogene 10031 / Q8NEV1* / P68400* / CSNK2A1* / CSNK2A3* / casein kinase 2 alpha 1* / casein kinase 2 alpha 3*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr