Manteia

ENSMUSG00000023439

Mus musculus

Features

Gene ID:	ENSMUSG00000023439

Biological name :	Gnb3

Synonyms :	Gnb3 / guanine nucleotide binding protein (G protein), beta 3 / Q61011

Possible biological names infered from orthology :	G protein subunit beta 3 / P16520

Species:	Mus musculus

Chr. number:	6
Strand:	-1
Band:	F2
Gene start:	124834240
Gene end:	124840275

Corresponding Affymetrix probe sets:	10547858 (MoGene1.0st) 1449159_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000024206 NCBI entrez gene - 14695 See in Manteia. MGI - MGI:95785 RefSeq - NM_013530 RefSeq Peptide - NP_038558 swissprot - Q54AE3 swissprot - Q61011 Ensembl - ENSMUSG00000023439

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gnb3a	ENSDARG00000004358	Danio rerio
gnb3b	ENSDARG00000002696	Danio rerio
GNB3	ENSGALG00000034438	Gallus gallus
GNB3	ENSG00000111664	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*	ENSMUSG00000029064	83
Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*	ENSMUSG00000029713	80
Gnb4 / P29387 / guanine nucleotide binding protein (G protein), beta 4 / Q9HAV0* / G protein subunit beta 4*	ENSMUSG00000027669	79
Gnb5 / P62881 / guanine nucleotide binding protein (G protein), beta 5 / O14775* / G protein subunit beta 5*	ENSMUSG00000032192	51
Wdr47 / Q8CGF6 / WD repeat domain 47 / O94967*	ENSMUSG00000040389	26

Protein motifs (from Interpro)

Interpro ID	Name
IPR001632	G-protein, beta subunit
IPR001680	WD40 repeat
IPR011042	Six-bladed beta-propeller, TolB-like
IPR015943	WD40/YVTN repeat-like-containing domain superfamily
IPR016346	Guanine nucleotide-binding protein, beta subunit
IPR017986	WD40-repeat-containing domain
IPR019775	WD40 repeat, conserved site
IPR020472	G-protein beta WD-40 repeat
IPR036322	WD40-repeat-containing domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	TAS
cellular_component	GO:0005834	heterotrimeric G-protein complex	TAS
cellular_component	GO:0030425	dendrite	IDA
cellular_component	GO:0043005	neuron projection	IEA
cellular_component	GO:0044297	cell body	IEA
molecular_function	GO:0003924	GTPase activity	TAS
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0030507	spectrin binding	IEA
molecular_function	GO:0051020	GTPase binding	IEA

Pathways (from Reactome)

Pathway description

Activation of G protein gated Potassium channels

Glucagon signaling in metabolic regulation

G-protein activation

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

ADP signalling through P2Y purinoceptor 12

G beta:gamma signalling through PI3Kgamma

Prostacyclin signalling through prostacyclin receptor

Adrenaline,noradrenaline inhibits insulin secretion

Ca2+ pathway

G alpha (q) signalling events

G alpha (12/13) signalling events

G beta:gamma signalling through PLC beta

G alpha (s) signalling events

ADP signalling through P2Y purinoceptor 1

G alpha (i) signalling events

G alpha (z) signalling events

Glucagon-type ligand receptors

Thromboxane signalling through TP receptor

Vasopressin regulates renal water homeostasis via Aquaporins

Thrombin signalling through proteinase activated receptors (PARs)

Presynaptic function of Kainate receptors

Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001005	abnormal rod morphology	"structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0004021	abnormal rod electrophysiology	"anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0004022	abnormal cone electrophysiology	"anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0005551	abnormal eye electrophysiology	"abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]	Show Allelic Composition: Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0006074	abnormal retinal rod bipolar cell morphology	"anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]	Show Allelic Composition: Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000044216	Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*	/ complex
ENSMUSG00000026824	Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*	/ complex
ENSMUSG00000042529	Kcnj12 / P52187 / ATP-sensitive inward rectifier potassium channel 12 / Q14500* / potassium voltage-gated channel subfamily J member 12*	/ complex
ENSMUSG00000038026	Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9 / Q92806* / potassium voltage-gated channel subfamily J member 9*	/ complex
ENSMUSG00000062609	Kcnj15 / O88932 / ATP-sensitive inward rectifier potassium channel 15 / Q99712* / potassium voltage-gated channel subfamily J member 15*	/ complex
ENSMUSG00000051497	Kcnj16 / Q9Z307 / Inward rectifier potassium channel 16 / Q9NPI9* / potassium voltage-gated channel subfamily J member 16*	/ complex
ENSMUSG00000032034	Kcnj5 / P48545 / G protein-activated inward rectifier potassium channel 4 / P48544* / potassium voltage-gated channel subfamily J member 5*	/ complex
ENSMUSG00000041695	Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2 / P63252* / potassium voltage-gated channel subfamily J member 2*	/ complex
ENSMUSG00000009030	Pdcl / Q9DBX2 / Phosducin-like protein / Q13371* / phosducin like*	/ complex
ENSMUSG00000043301	Kcnj6 / G protein-activated inward rectifier potassium channel 2 isoform Girk2B / P48051* / potassium voltage-gated channel subfamily J member 6*	/ complex
ENSMUSG00000027523	Gnas / Q9Z0F1 / P63094 / Q6R0H6 / Q6R0H7 / GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus / P84996* / Q5JWF2* / O95467* / P63092* / GNAS complex locus*	/ complex
ENSMUSG00000044708	Kcnj10 / Q9JM63 / ATP-sensitive inward rectifier potassium channel 10 / P78508* / potassium voltage-gated channel subfamily J member 10*	/ complex
ENSMUSG00000043004	Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*	/ complex / reaction
ENSMUSG00000025127	Gcgr / Q61606 / Glucagon receptor / P47871*	/ reaction
ENSMUSG00000024462	Gabbr1 / Q9WV18 / Gamma-aminobutyric acid type B receptor subunit 1 / Q9UBS5*	/ complex
ENSMUSG00000028777	Gnat3 / Q3V3I2 / guanine nucleotide binding protein, alpha transducing 3 / A8MTJ3* / G protein subunit alpha transducin 3*	/ complex
ENSMUSG00000039809	Gabbr2 / Q80T41 / Gamma-aminobutyric acid type B receptor subunit 2 / O75899*	/ complex
ENSMUSG00000025739	Gng13 / Q9JMF3 / guanine nucleotide binding protein (G protein), gamma 13 / Q9P2W3* / G protein subunit gamma 13*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr