Manteia

ENSMUSG00000041695

Mus musculus

Features

Gene ID:	ENSMUSG00000041695

Biological name :	Kcnj2

Synonyms :	Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2

Possible biological names infered from orthology :	P63252 / potassium voltage-gated channel subfamily J member 2

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	E2
Gene start:	111066164
Gene end:	111076821

Corresponding Affymetrix probe sets:	10382321 (MoGene1.0st) 1450503_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000037192 NCBI entrez gene - 16518 See in Manteia. MGI - MGI:104744 RefSeq - NM_008425 RefSeq Peptide - NP_032451 swissprot - P35561 swissprot - Q543W5 Ensembl - ENSMUSG00000041695

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
kcnj2a	ENSDARG00000019418	Danio rerio
kcnj2b	ENSDARG00000104389	Danio rerio
KCNJ2	ENSGALG00000004376	Gallus gallus
KCNJ2	ENSG00000123700	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kcnj12 / P52187 / ATP-sensitive inward rectifier potassium channel 12 / Q14500* / potassium voltage-gated channel subfamily J member 12*	ENSMUSG00000042529	71
Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*	ENSMUSG00000044216	62
Kcnj14 / Q8JZN3 / ATP-sensitive inward rectifier potassium channel 14 / Q9UNX9* / potassium voltage-gated channel subfamily J member 14*	ENSMUSG00000058743	58
Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*	ENSMUSG00000026824	45
Kcnj6 / G protein-activated inward rectifier potassium channel 2 isoform Girk2B / P48051* / potassium voltage-gated channel subfamily J member 6*	ENSMUSG00000043301	44
Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9 / Q92806* / potassium voltage-gated channel subfamily J member 9*	ENSMUSG00000038026	44
Kcnj5 / P48545 / G protein-activated inward rectifier potassium channel 4 / P48544* / potassium voltage-gated channel subfamily J member 5*	ENSMUSG00000032034	44
Kcnj8 / P97794 / potassium inwardly-rectifying channel, subfamily J, member 8 / Q15842* / potassium voltage-gated channel subfamily J member 8*	ENSMUSG00000030247	42
Kcnj11 / Q61743 / ATP-sensitive inward rectifier potassium channel 11 / Q14654* / potassium voltage-gated channel subfamily J member 11*	ENSMUSG00000096146	39
Kcnj1 / O88335 / ATP-sensitive inward rectifier potassium channel 1 / P48048* / potassium voltage-gated channel subfamily J member 1*	ENSMUSG00000041248	37
Kcnj10 / Q9JM63 / ATP-sensitive inward rectifier potassium channel 10 / P78508* / potassium voltage-gated channel subfamily J member 10*	ENSMUSG00000044708	34
Kcnj15 / O88932 / ATP-sensitive inward rectifier potassium channel 15 / Q99712* / potassium voltage-gated channel subfamily J member 15*	ENSMUSG00000062609	33

Protein motifs (from Interpro)

Interpro ID	Name
IPR003271	Potassium channel, inwardly rectifying, Kir2.1
IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
IPR013673	Potassium channel, inwardly rectifying, Kir, N-terminal
IPR014756	Immunoglobulin E-set
IPR016449	Potassium channel, inwardly rectifying, Kir

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006813	potassium ion transport	ISO
biological_process	GO:0010107	potassium ion import	IEA
biological_process	GO:0014861	regulation of skeletal muscle contraction via regulation of action potential	IEA
biological_process	GO:0015693	magnesium ion transport	IDA
biological_process	GO:0034765	regulation of ion transmembrane transport	IEA
biological_process	GO:0051289	protein homotetramerization	IEA
biological_process	GO:0055119	relaxation of cardiac muscle	IEA
biological_process	GO:0060306	regulation of membrane repolarization	IEA
biological_process	GO:0071260	cellular response to mechanical stimulus	IEA
biological_process	GO:0071805	potassium ion transmembrane transport	IEA
biological_process	GO:0086001	cardiac muscle cell action potential	IMP
biological_process	GO:0086002	cardiac muscle cell action potential involved in contraction	IEA
biological_process	GO:0086004	regulation of cardiac muscle cell contraction	IEA
biological_process	GO:0086011	membrane repolarization during action potential	IEA
biological_process	GO:0086013	membrane repolarization during cardiac muscle cell action potential	IEA
biological_process	GO:0086091	regulation of heart rate by cardiac conduction	IEA
biological_process	GO:0090076	relaxation of skeletal muscle	IEA
biological_process	GO:1901381	positive regulation of potassium ion transmembrane transport	IEA
cellular_component	GO:0005790	smooth endoplasmic reticulum	IEA
cellular_component	GO:0005791	rough endoplasmic reticulum	IEA
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0008076	voltage-gated potassium channel complex	IEA
cellular_component	GO:0014704	intercalated disc	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030315	T-tubule	IEA
cellular_component	GO:0030425	dendrite	IEA
cellular_component	GO:0031224	intrinsic component of membrane	IEA
cellular_component	GO:0043025	neuronal cell body	IEA
cellular_component	GO:0043197	dendritic spine	IEA
molecular_function	GO:0005242	inward rectifier potassium channel activity	ISO
molecular_function	GO:0005244	voltage-gated ion channel activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IEA
molecular_function	GO:0042802	identical protein binding	IPI
molecular_function	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	IEA

Pathways (from Reactome)

Pathway description

Activation of G protein gated Potassium channels

Classical Kir channels

Phase 4 - resting membrane potential

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001429	dehydration	"excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]	Show Allelic Composition: Plxna3^tm1Matl/Y Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)
MP:0001436	abnormal suckling behavior	"reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]	Show Allelic Composition: Plxna3^tm1Matl/Y Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Plxna3^tm1Matl/Y Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)
MP:0001613	abnormal vasodilation	"anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Plxna3^tm1Matl/Y Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Plxna3^tm1Matl/Y Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)
MP:0009888	palatal shelves fail to meet at midline	"polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]	Show Allelic Composition: Plxna3^tm1Matl/Y Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Plxna3^tm1Matl/Y Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Plxna3^tm1Matl/Y Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)
MP:0030248	narrow maxilla	"reduced width of the upper bony framework of the mouth where the superior teeth are held" [MGI:anna]	Show Allelic Composition: Plxna3^tm1Matl/Y Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000023439	Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*	/ complex
ENSMUSG00000024462	Gabbr1 / Q9WV18 / Gamma-aminobutyric acid type B receptor subunit 1 / Q9UBS5*	/ complex
ENSMUSG00000029713	Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*	/ complex
ENSMUSG00000041695	Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2 / P63252* / potassium voltage-gated channel subfamily J member 2*	/ complex
ENSMUSG00000058743	Kcnj14 / Q8JZN3 / ATP-sensitive inward rectifier potassium channel 14 / Q9UNX9* / potassium voltage-gated channel subfamily J member 14*	/ complex
ENSMUSG00000042529	Kcnj12 / P52187 / ATP-sensitive inward rectifier potassium channel 12 / Q14500* / potassium voltage-gated channel subfamily J member 12*	/ complex
ENSMUSG00000029064	Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*	/ complex
ENSMUSG00000044708	Kcnj10 / Q9JM63 / ATP-sensitive inward rectifier potassium channel 10 / P78508* / potassium voltage-gated channel subfamily J member 10*	/ complex
ENSMUSG00000044216	Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*	/ complex
ENSMUSG00000039809	Gabbr2 / Q80T41 / Gamma-aminobutyric acid type B receptor subunit 2 / O75899*	/ complex
ENSMUSG00000051497	Kcnj16 / Q9Z307 / Inward rectifier potassium channel 16 / Q9NPI9* / potassium voltage-gated channel subfamily J member 16*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr