ENSGALG00000004376


Gallus gallus

Features
Gene ID: ENSGALG00000004376
  
Biological name :KCNJ2
  
Synonyms : inward rectifier potassium channel 2 / KCNJ2
  
Possible biological names infered from orthology : P35561 / P63252 / potassium inwardly-rectifying channel, subfamily J, member 2 / potassium voltage-gated channel subfamily J member 2
  
Species: Gallus gallus
  
Chr. number: 18
Strand: 1
Band:
Gene start: 8259055
Gene end: 8265799
  
Corresponding Affymetrix probe sets: Gga.254.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000006967
NCBI entrez gene - 396328     See in Manteia.
RefSeq - NM_205370
RefSeq Peptide - NP_990701
swissprot - O42229
Ensembl - ENSGALG00000004376
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnj2aENSDARG00000019418Danio rerio
 kcnj2bENSDARG00000104389Danio rerio
 KCNJ2ENSG00000123700Homo sapiens
 Kcnj2ENSMUSG00000041695Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F1NHE9 / ATP-sensitive inward rectifier potassium channel 12 / KCNJ18* / P52187* / Q14500* / B7U540* / KCNJ12* / potassium voltage-gated channel subfamily J member 18* / potassium voltage-...ENSGALG0000000472171
KCNJ4 / potassium voltage-gated channel subfamily J member 4 / P48050*ENSGALG0000001225464
KCNJ5 / potassium voltage-gated channel subfamily J member 5 / P48544* / P48545* / G protein-activated inward rectifier potassium channel 4 *ENSGALG0000000118144
KCNJ6 / potassium voltage-gated channel subfamily J member 6 / P48051* / G protein-activated inward rectifier potassium channel 2 isoform Girk2B *ENSGALG0000001605444
KCNJ3 / G protein-activated inward rectifier potassium channel 1 / P48549* / P63250* / potassium voltage-gated channel subfamily J member 3*ENSGALG0000001253744
ENSGALG0000000993543
KCNJ8 / ATP-sensitive inward rectifier potassium channel 8 / P97794* / Q15842* / potassium voltage-gated channel subfamily J member 8* / potassium inwardly-rectifying channel, subfamily J, member 8*ENSGALG0000002637342
KCNJ11 / potassium voltage-gated channel subfamily J member 11 / Q14654* / Q61743* / ATP-sensitive inward rectifier potassium channel 11 *ENSGALG0000002050541
ENSGALG0000000692237
KCNJ1 / potassium voltage-gated channel subfamily J member 1 / O88335* / P48048* / ATP-sensitive inward rectifier potassium channel 1 *ENSGALG0000000116736
KCNJ15 / potassium voltage-gated channel subfamily J member 15 / O88932* / Q99712* / ATP-sensitive inward rectifier potassium channel 15 *ENSGALG0000001605534


Protein motifs (from Interpro)
Interpro ID Name
 IPR003271  Potassium channel, inwardly rectifying, Kir2.1
 IPR013518  Potassium channel, inwardly rectifying, Kir, cytoplasmic
 IPR013673  Potassium channel, inwardly rectifying, Kir, N-terminal
 IPR014756  Immunoglobulin E-set
 IPR016449  Potassium channel, inwardly rectifying, Kir


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0010107 potassium ion import IEA
 biological_processGO:0014861 regulation of skeletal muscle contraction via regulation of action potential IEA
 biological_processGO:0015693 magnesium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0055119 relaxation of cardiac muscle IEA
 biological_processGO:0060306 regulation of membrane repolarization IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0086001 cardiac muscle cell action potential IEA
 biological_processGO:0086002 cardiac muscle cell action potential involved in contraction IEA
 biological_processGO:0086011 membrane repolarization during action potential IEA
 biological_processGO:0086013 membrane repolarization during cardiac muscle cell action potential IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IEA
 biological_processGO:0090076 relaxation of skeletal muscle IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031224 intrinsic component of membrane IEA
 molecular_functionGO:0005242 inward rectifier potassium channel activity IBA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization IEA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Classical Kir channels
Phase 4 - resting membrane potential
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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