Manteia

ENSMUSG00000032034

Mus musculus

Features

Gene ID:	ENSMUSG00000032034

Biological name :	Kcnj5

Synonyms :	G protein-activated inward rectifier potassium channel 4 / Kcnj5 / P48545

Possible biological names infered from orthology :	P48544 / potassium voltage-gated channel subfamily J member 5

Species:	Mus musculus

Chr. number:	9
Strand:	-1
Band:	A4
Gene start:	32314707
Gene end:	32344350

Corresponding Affymetrix probe sets:	10592061 (MoGene1.0st) 1421762_at (Mouse Genome 430 2.0 Array) 1441590_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000034533 Ensembl peptide - ENSMUSP00000149000 Ensembl peptide - ENSMUSP00000149461 NCBI entrez gene - 16521 See in Manteia. MGI - MGI:104755 RefSeq - XM_017313155 RefSeq - NM_010605 RefSeq - XM_006510039 RefSeq - XM_017313153 RefSeq Peptide - NP_034735 swissprot - A0A1L1SRH1 swissprot - P48545 Ensembl - ENSMUSG00000032034

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
kcnj5	ENSDARG00000061014	Danio rerio
KCNJ5	ENSGALG00000001181	Gallus gallus
KCNJ5	ENSG00000120457	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kcnj6 / G protein-activated inward rectifier potassium channel 2 isoform Girk2B / P48051* / potassium voltage-gated channel subfamily J member 6*	ENSMUSG00000043301	69
Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9 / Q92806* / potassium voltage-gated channel subfamily J member 9*	ENSMUSG00000038026	61
Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*	ENSMUSG00000026824	54
Kcnj12 / P52187 / ATP-sensitive inward rectifier potassium channel 12 / Q14500* / potassium voltage-gated channel subfamily J member 12*	ENSMUSG00000042529	46
Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*	ENSMUSG00000044216	45
Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2 / P63252* / potassium voltage-gated channel subfamily J member 2*	ENSMUSG00000041695	45
Kcnj14 / Q8JZN3 / ATP-sensitive inward rectifier potassium channel 14 / Q9UNX9* / potassium voltage-gated channel subfamily J member 14*	ENSMUSG00000058743	42
Kcnj8 / P97794 / potassium inwardly-rectifying channel, subfamily J, member 8 / Q15842* / potassium voltage-gated channel subfamily J member 8*	ENSMUSG00000030247	39
Kcnj1 / O88335 / ATP-sensitive inward rectifier potassium channel 1 / P48048* / potassium voltage-gated channel subfamily J member 1*	ENSMUSG00000041248	38
Kcnj11 / Q61743 / ATP-sensitive inward rectifier potassium channel 11 / Q14654* / potassium voltage-gated channel subfamily J member 11*	ENSMUSG00000096146	38
Kcnj10 / Q9JM63 / ATP-sensitive inward rectifier potassium channel 10 / P78508* / potassium voltage-gated channel subfamily J member 10*	ENSMUSG00000044708	33
Kcnj15 / O88932 / ATP-sensitive inward rectifier potassium channel 15 / Q99712* / potassium voltage-gated channel subfamily J member 15*	ENSMUSG00000062609	30

Protein motifs (from Interpro)

Interpro ID	Name
IPR003277	Potassium channel, inwardly rectifying, Kir3.4
IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
IPR014756	Immunoglobulin E-set
IPR016449	Potassium channel, inwardly rectifying, Kir

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006813	potassium ion transport	IEA
biological_process	GO:0010107	potassium ion import	ISO
biological_process	GO:0034220	ion transmembrane transport	IEA
biological_process	GO:0034765	regulation of ion transmembrane transport	IEA
biological_process	GO:0071805	potassium ion transmembrane transport	IEA
biological_process	GO:0086091	regulation of heart rate by cardiac conduction	ISO
biological_process	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential	ISO
biological_process	GO:1990573	potassium ion import across plasma membrane	ISO
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0008076	voltage-gated potassium channel complex	ISO
cellular_component	GO:0009897	external side of plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030315	T-tubule	IEA
molecular_function	GO:0005242	inward rectifier potassium channel activity	ISO
molecular_function	GO:0005244	voltage-gated ion channel activity	IEA
molecular_function	GO:0015467	G-protein activated inward rectifier potassium channel activity	IEA
molecular_function	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	ISO

Pathways (from Reactome)

Pathway description

Activation of G protein gated Potassium channels

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001629	abnormal heart rate	"greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Igf2^tm1Kel/Igf2⁺,Phlda2^tm2Bty/Phlda2⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0002626	increased heart rate	"greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Tph2^tm2.1Pasq/Tph2^tm2.2Pasq,Tg(CMV-cre/ERT)1Ipc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000023439	Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*	/ complex
ENSMUSG00000024462	Gabbr1 / Q9WV18 / Gamma-aminobutyric acid type B receptor subunit 1 / Q9UBS5*	/ complex
ENSMUSG00000029713	Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*	/ complex
ENSMUSG00000032034	Kcnj5 / P48545 / G protein-activated inward rectifier potassium channel 4 / P48544* / potassium voltage-gated channel subfamily J member 5*	/ complex
ENSMUSG00000029064	Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*	/ complex
ENSMUSG00000038026	Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9 / Q92806* / potassium voltage-gated channel subfamily J member 9*	/ complex
ENSMUSG00000026824	Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*	/ complex
ENSMUSG00000043301	Kcnj6 / G protein-activated inward rectifier potassium channel 2 isoform Girk2B / P48051* / potassium voltage-gated channel subfamily J member 6*	/ complex
ENSMUSG00000039809	Gabbr2 / Q80T41 / Gamma-aminobutyric acid type B receptor subunit 2 / O75899*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr