ENSMUSG00000044708


Mus musculus

Features
Gene ID: ENSMUSG00000044708
  
Biological name :Kcnj10
  
Synonyms : ATP-sensitive inward rectifier potassium channel 10 / Kcnj10 / Q9JM63
  
Possible biological names infered from orthology : P78508 / potassium voltage-gated channel subfamily J member 10
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 172341210
Gene end: 172374085
  
Corresponding Affymetrix probe sets: 10351781 (MoGene1.0st)   1419601_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054356
NCBI entrez gene - 16513     See in Manteia.
MGI - MGI:1194504
RefSeq - XM_006496677
RefSeq - NM_001039484
RefSeq Peptide - NP_001034573
swissprot - Q56VN0
swissprot - Q9JM63
Ensembl - ENSMUSG00000044708
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704813.1ENSDARG00000105022Danio rerio
 kcnj10aENSDARG00000090815Danio rerio
 KCNJ10ENSG00000177807Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnj15 / O88932 / ATP-sensitive inward rectifier potassium channel 15 / Q99712* / potassium voltage-gated channel subfamily J member 15*ENSMUSG0000006260960
Kcnj1 / O88335 / ATP-sensitive inward rectifier potassium channel 1 / P48048* / potassium voltage-gated channel subfamily J member 1*ENSMUSG0000004124846
Kcnj12 / P52187 / ATP-sensitive inward rectifier potassium channel 12 / Q14500* / potassium voltage-gated channel subfamily J member 12*ENSMUSG0000004252939
Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2 / P63252* / potassium voltage-gated channel subfamily J member 2*ENSMUSG0000004169538
Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9 / Q92806* / potassium voltage-gated channel subfamily J member 9*ENSMUSG0000003802637
Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*ENSMUSG0000004421637
Kcnj14 / Q8JZN3 / ATP-sensitive inward rectifier potassium channel 14 / Q9UNX9* / potassium voltage-gated channel subfamily J member 14*ENSMUSG0000005874337
Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*ENSMUSG0000002682436
Kcnj5 / P48545 / G protein-activated inward rectifier potassium channel 4 / P48544* / potassium voltage-gated channel subfamily J member 5*ENSMUSG0000003203436
Kcnj8 / P97794 / potassium inwardly-rectifying channel, subfamily J, member 8 / Q15842* / potassium voltage-gated channel subfamily J member 8*ENSMUSG0000003024735
Kcnj6 / G protein-activated inward rectifier potassium channel 2 isoform Girk2B / P48051* / potassium voltage-gated channel subfamily J member 6*ENSMUSG0000004330135
Kcnj11 / Q61743 / ATP-sensitive inward rectifier potassium channel 11 / Q14654* / potassium voltage-gated channel subfamily J member 11*ENSMUSG0000009614635


Protein motifs (from Interpro)
Interpro ID Name
 IPR003269  Potassium channel, inwardly rectifying, Kir1.2
 IPR013518  Potassium channel, inwardly rectifying, Kir, cytoplasmic
 IPR014756  Immunoglobulin E-set
 IPR016449  Potassium channel, inwardly rectifying, Kir


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IDA
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0010107 potassium ion import IBA
 biological_processGO:0014003 oligodendrocyte development IMP
 biological_processGO:0022010 central nervous system myelination IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IMP
 biological_processGO:0051935 glutamate reuptake IMP
 biological_processGO:0055075 potassium ion homeostasis IMP
 biological_processGO:0060075 regulation of resting membrane potential IMP
 biological_processGO:0071805 potassium ion transmembrane transport ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005242 inward rectifier potassium channel activity ISO
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015272 ATP-activated inward rectifier potassium channel activity IBA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Potassium transport channels
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0000048 abnormal stria vascularis "anomalous structure of the layer of highly vascularized pigmented granular cells on the outer wall of the cochlear duct" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Kcnj10tm1Lst/Kcnj10tm1Lst
Genetic Background: involves: 129S1/Sv

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kcnj10tm1Lst/Kcnj10tm1Lst
Genetic Background: involves: 129S1/Sv

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnj10tm1Lst/Kcnj10tm1Lst
Genetic Background: involves: 129S1/Sv

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0002923 increased post-tetanic potential "increase in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0002986 hypocalciuria "excretion of abnormally low amounts of calcium in the urine" [J:83000]
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Allelic Composition: Kcnj10tm1Lst/Kcnj10tm1Lst
Genetic Background: involves: 129S1/Sv

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0003169 abnormal scala media morphology "any malformation or absence of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)" [J:23837, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0004298 vestibular ganglion degeneration "loss of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0004324 vestibular hair cell degeneration "degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0004331 saccular macula degeneration "degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0004334 utricular macular degeneration "degeneration or loss of the neuroepithelial sensory receptor in the inferolateral wall of the utricle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0004409 abnormal neuroepithelium of ampullary crest "any structural abnormality in the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0004410 absent endocochlear potential "absence of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea, indicating a primary defect in fluid homeostasis of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0004716 abnormal cochlear nerve morphology "any structural abnormality in the part of the vestibulocochlear nerve [CN VIII] peripheral to the cochlear root; composed of the central nerve processes of the bipolar neurons of the spiral ganglion, which have their peripheral processes on the four rows of neuroepithelial cells (hair cells) of the spiral organ" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0005176 eyelids fail to open "eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0005424 jerky movement "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0006021 abnormal Reissner membrane morphology "any strutural alteration in Reissner s membrane which separates the cochlear duct from the vestibular canal, i.e. the endolymph of the scala media from the perilymph of the scala vestibuli; the Reissner membrane consists of squamous epithelial cells with microvilli toward the ductus, a basement membrane, and a thin layer of connective tissue toward the scala. " [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0006024 collapsed Reissner membrane "the Reissner s membrane, which normally separates the scala media from the scala vestibuli, has collapsed onto the spiral limbus and the tectorial membrane of the organ of Corti" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:37461:]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0006025 distended Reissner membrane "an increase in the volume of endolymphatic fluid that results in distortion of the vestibular membrane" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcnj10tm1Lst/Kcnj10tm1Lst
Genetic Background: involves: 129S1/Sv

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0006403 abnormal cochlear endolymph ionic homeostasis "anomaly in the state of equilibrium in the cochlear endolymph with respect to charged molecules; cochlear endolymph is not only an unusual extracellular fluid for its high potassium ion and low sodium ion concentration but also for its low calcium ion concentration, high HCO3- concentration and low protein content" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0008027 abnormal spinal cord white matter morphology "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Kcnj10tm1Lst/Kcnj10tm1Lst
Genetic Background: involves: 129S1/Sv

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Kcnj10tm1Lst/Kcnj10tm1Lst
Genetic Background: involves: 129S1/Sv

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023439 Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*  / complex
 ENSMUSG00000024462 Gabbr1 / Q9WV18 / Gamma-aminobutyric acid type B receptor subunit 1 / Q9UBS5*  / complex
 ENSMUSG00000029713 Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*  / complex
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex
 ENSMUSG00000042529 Kcnj12 / P52187 / ATP-sensitive inward rectifier potassium channel 12 / Q14500* / potassium voltage-gated channel subfamily J member 12*  / complex
 ENSMUSG00000044708 Kcnj10 / Q9JM63 / ATP-sensitive inward rectifier potassium channel 10 / P78508* / potassium voltage-gated channel subfamily J member 10*  / complex
 ENSMUSG00000041695 Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2 / P63252* / potassium voltage-gated channel subfamily J member 2*  / complex
 ENSMUSG00000044216 Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*  / complex
 ENSMUSG00000039809 Gabbr2 / Q80T41 / Gamma-aminobutyric acid type B receptor subunit 2 / O75899*  / complex
 ENSMUSG00000051497 Kcnj16 / Q9Z307 / Inward rectifier potassium channel 16 / Q9NPI9* / potassium voltage-gated channel subfamily J member 16*  / complex






 

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