ENSMUSG00000042529


Mus musculus

Features
Gene ID: ENSMUSG00000042529
  
Biological name :Kcnj12
  
Synonyms : ATP-sensitive inward rectifier potassium channel 12 / Kcnj12 / P52187
  
Possible biological names infered from orthology : potassium voltage-gated channel subfamily J member 12 / Q14500
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B2
Gene start: 61022564
Gene end: 61071131
  
Corresponding Affymetrix probe sets: 10376747 (MoGene1.0st)   1422871_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041696
Ensembl peptide - ENSMUSP00000086588
Ensembl peptide - ENSMUSP00000104357
NCBI entrez gene - 16515     See in Manteia.
MGI - MGI:108495
RefSeq - XM_006532318
RefSeq - NM_001267593
RefSeq - NM_010603
RefSeq Peptide - NP_001254522
RefSeq Peptide - NP_034733
swissprot - P52187
swissprot - B1ATI1
Ensembl - ENSMUSG00000042529
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnj12aENSDARG00000104965Danio rerio
 F1NHE9ENSGALG00000004721Gallus gallus
 KCNJ12ENSG00000184185Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2 / P63252* / potassium voltage-gated channel subfamily J member 2*ENSMUSG0000004169557
Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*ENSMUSG0000004421653
Kcnj14 / Q8JZN3 / ATP-sensitive inward rectifier potassium channel 14 / Q9UNX9* / potassium voltage-gated channel subfamily J member 14*ENSMUSG0000005874346
Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9 / Q92806* / potassium voltage-gated channel subfamily J member 9*ENSMUSG0000003802637
Kcnj5 / P48545 / G protein-activated inward rectifier potassium channel 4 / P48544* / potassium voltage-gated channel subfamily J member 5*ENSMUSG0000003203436
Kcnj6 / G protein-activated inward rectifier potassium channel 2 isoform Girk2B / P48051* / potassium voltage-gated channel subfamily J member 6*ENSMUSG0000004330135
Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*ENSMUSG0000002682435
Kcnj11 / Q61743 / ATP-sensitive inward rectifier potassium channel 11 / Q14654* / potassium voltage-gated channel subfamily J member 11*ENSMUSG0000009614633
Kcnj8 / P97794 / potassium inwardly-rectifying channel, subfamily J, member 8 / Q15842* / potassium voltage-gated channel subfamily J member 8*ENSMUSG0000003024733
Kcnj1 / O88335 / ATP-sensitive inward rectifier potassium channel 1 / P48048* / potassium voltage-gated channel subfamily J member 1*ENSMUSG0000004124831
Kcnj10 / Q9JM63 / ATP-sensitive inward rectifier potassium channel 10 / P78508* / potassium voltage-gated channel subfamily J member 10*ENSMUSG0000004470828
Kcnj15 / O88932 / ATP-sensitive inward rectifier potassium channel 15 / Q99712* / potassium voltage-gated channel subfamily J member 15*ENSMUSG0000006260926


Protein motifs (from Interpro)
Interpro ID Name
 IPR003272  Potassium channel, inwardly rectifying, Kir2.2
 IPR013518  Potassium channel, inwardly rectifying, Kir, cytoplasmic
 IPR013673  Potassium channel, inwardly rectifying, Kir, N-terminal
 IPR014756  Immunoglobulin E-set
 IPR016449  Potassium channel, inwardly rectifying, Kir


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport ISO
 biological_processGO:0010107 potassium ion import IBA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051289 protein homotetramerization ISO
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031224 intrinsic component of membrane ISS
 molecular_functionGO:0005242 inward rectifier potassium channel activity ISO
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Classical Kir channels
Phase 4 - resting membrane potential
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023439 Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*  / complex
 ENSMUSG00000024462 Gabbr1 / Q9WV18 / Gamma-aminobutyric acid type B receptor subunit 1 / Q9UBS5*  / complex
 ENSMUSG00000029713 Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*  / complex
 ENSMUSG00000041695 Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2 / P63252* / potassium voltage-gated channel subfamily J member 2*  / complex
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex
 ENSMUSG00000044708 Kcnj10 / Q9JM63 / ATP-sensitive inward rectifier potassium channel 10 / P78508* / potassium voltage-gated channel subfamily J member 10*  / complex
 ENSMUSG00000042529 Kcnj12 / P52187 / ATP-sensitive inward rectifier potassium channel 12 / Q14500* / potassium voltage-gated channel subfamily J member 12*  / complex
 ENSMUSG00000058743 Kcnj14 / Q8JZN3 / ATP-sensitive inward rectifier potassium channel 14 / Q9UNX9* / potassium voltage-gated channel subfamily J member 14*  / complex
 ENSMUSG00000044216 Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*  / complex
 ENSMUSG00000039809 Gabbr2 / Q80T41 / Gamma-aminobutyric acid type B receptor subunit 2 / O75899*  / complex
 ENSMUSG00000051497 Kcnj16 / Q9Z307 / Inward rectifier potassium channel 16 / Q9NPI9* / potassium voltage-gated channel subfamily J member 16*  / complex






 

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