ENSMUSG00000039809


Mus musculus

Features
Gene ID: ENSMUSG00000039809
  
Biological name :Gabbr2
  
Synonyms : Gabbr2 / Gamma-aminobutyric acid type B receptor subunit 2 / Q80T41
  
Possible biological names infered from orthology : O75899
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B1
Gene start: 46662305
Gene end: 46991873
  
Corresponding Affymetrix probe sets: 10512807 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000146296
Ensembl peptide - ENSMUSP00000103378
NCBI entrez gene - 242425     See in Manteia.
MGI - MGI:2386030
RefSeq - NM_001081141
RefSeq Peptide - NP_001074610
swissprot - A0A0U1RQ90
swissprot - Q80T41
Ensembl - ENSMUSG00000039809
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabbr2ENSDARG00000061042Danio rerio
 GABBR2ENSGALG00000013200Gallus gallus
 GABBR2ENSG00000136928Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gabbr1 / Q9WV18 / Gamma-aminobutyric acid type B receptor subunit 1 / Q9UBS5*ENSMUSG0000002446227
Gpr156 / G protein-coupled receptor 156 / Q8NFN8*ENSMUSG0000004696110


Protein motifs (from Interpro)
Interpro ID Name
 IPR000337  GPCR, family 3
 IPR001828  Receptor, ligand binding region
 IPR002455  GPCR family 3, GABA-B receptor
 IPR002457  GPCR family 3, gamma-aminobutyric acid receptor, type B2
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0038039 G-protein coupled receptor heterodimeric complex IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1902710 GABA receptor complex IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004965 G-protein coupled GABA receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
GABA B receptor activation
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

Allelic Composition: Gabbr2tm1Bet/Gabbr2+
Genetic Background: BALB/c-Gabbr2tm1Bet

 MP:0002738 hyperresponsive to tactile stimuli "exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

Allelic Composition: Gabbr2tm1.1Stmo/Gabbr2tm1.1Stmo
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002911 abnormal inhibitory postsynaptic potential "defect in the membrane potential detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

Allelic Composition: Gabbr2tm1Arca/Gabbr2tm1Arca
Genetic Background: involves: 129P2/OlaHsd

 MP:0003360 depression-related behavior 
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Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

 MP:0003996 clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gabbr2tm1Arca/Gabbr2tm1Arca
Genetic Background: involves: 129P2/OlaHsd

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabbr2tm1.1Stmo/Gabbr2tm1.1Stmo
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

 MP:0008263 abnormal hippocampus CA1 region morphology 
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Allelic Composition: Gabbr2tm1.1Stmo/Gabbr2tm1.1Stmo
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabbr2tm1.1Stmo/Gabbr2tm1.1Stmo
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabbr2tm1.1Stmo/Gabbr2tm1.1Stmo
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Gabbr2tm1.1Stmo/Gabbr2tm1.1Stmo
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabbr1tm1Bet/Gabbr1+
Genetic Background: BALB/c-Gabbr1tm1Bet

 MP:0012006 abnormal hippocampus physiology "any functional anomaly related to processes in the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [MPD:Molly]
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Allelic Composition: Gabbr2tm1.1Stmo/Gabbr2tm1.1Stmo
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026824 Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*  / complex
 ENSMUSG00000029713 Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*  / complex
 ENSMUSG00000044216 Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*  / complex
 ENSMUSG00000043301 Kcnj6 / G protein-activated inward rectifier potassium channel 2 isoform Girk2B / P48051* / potassium voltage-gated channel subfamily J member 6*  / complex
 ENSMUSG00000044708 Kcnj10 / Q9JM63 / ATP-sensitive inward rectifier potassium channel 10 / P78508* / potassium voltage-gated channel subfamily J member 10*  / complex
 ENSMUSG00000062609 Kcnj15 / O88932 / ATP-sensitive inward rectifier potassium channel 15 / Q99712* / potassium voltage-gated channel subfamily J member 15*  / complex
 ENSMUSG00000051497 Kcnj16 / Q9Z307 / Inward rectifier potassium channel 16 / Q9NPI9* / potassium voltage-gated channel subfamily J member 16*  / complex
 ENSMUSG00000024462 Gabbr1 / Q9WV18 / Gamma-aminobutyric acid type B receptor subunit 1 / Q9UBS5*  / complex
 ENSMUSG00000042529 Kcnj12 / P52187 / ATP-sensitive inward rectifier potassium channel 12 / Q14500* / potassium voltage-gated channel subfamily J member 12*  / complex
 ENSMUSG00000038026 Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9 / Q92806* / potassium voltage-gated channel subfamily J member 9*  / complex
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex
 ENSMUSG00000032034 Kcnj5 / P48545 / G protein-activated inward rectifier potassium channel 4 / P48544* / potassium voltage-gated channel subfamily J member 5*  / complex
 ENSMUSG00000041695 Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2 / P63252* / potassium voltage-gated channel subfamily J member 2*  / complex
 ENSMUSG00000023439 Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*  / complex






 

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