Manteia - Molecule gene

ENSMUSG00000043301

Mus musculus

Features

Gene ID:	ENSMUSG00000043301

Biological name :	Kcnj6

Synonyms :	G protein-activated inward rectifier potassium channel 2 isoform Girk2B / Kcnj6

Possible biological names infered from orthology :	P48051 / potassium voltage-gated channel subfamily J member 6

Species:	Mus musculus

Chr. number:	16
Strand:	-1
Band:	C4
Gene start:	94749266
Gene end:	94997696

Corresponding Affymetrix probe sets:	10441073 (MoGene1.0st) 1421581_at (Mouse Genome 430 2.0 Array) 1425044_at (Mouse Genome 430 2.0 Array) 1425707_a_at (Mouse Genome 430 2.0 Array) 1450294_a_at (Mouse Genome 430 2.0 Array) 1451868_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000093558 Ensembl peptide - ENSMUSP00000097108 Ensembl peptide - ENSMUSP00000130321 NCBI entrez gene - 16522 See in Manteia. MGI - MGI:104781 RefSeq - XM_011246104 RefSeq - NM_001025584 RefSeq - NM_001025585 RefSeq - NM_001025590 RefSeq - NM_010606 RefSeq Peptide - NP_001020755 RefSeq Peptide - NP_001020756 RefSeq Peptide - NP_001020761 RefSeq Peptide - NP_034736 swissprot - Q0VB45 swissprot - Q8C4T8 swissprot - A0A0R4J239 Ensembl - ENSMUSG00000043301

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
KCNJ6	ENSDARG00000058985	Danio rerio
KCNJ6	ENSGALG00000016054	Gallus gallus
KCNJ6	ENSG00000157542	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kcnj5 / P48545 / G protein-activated inward rectifier potassium channel 4 / P48544* / potassium voltage-gated channel subfamily J member 5*	ENSMUSG00000032034	68
Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9 / Q92806* / potassium voltage-gated channel subfamily J member 9*	ENSMUSG00000038026	64
Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*	ENSMUSG00000026824	53
Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2 / P63252* / potassium voltage-gated channel subfamily J member 2*	ENSMUSG00000041695	45
Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*	ENSMUSG00000044216	44
Kcnj12 / P52187 / ATP-sensitive inward rectifier potassium channel 12 / Q14500* / potassium voltage-gated channel subfamily J member 12*	ENSMUSG00000042529	44
Kcnj8 / P97794 / potassium inwardly-rectifying channel, subfamily J, member 8 / Q15842* / potassium voltage-gated channel subfamily J member 8*	ENSMUSG00000030247	40
Kcnj14 / Q8JZN3 / ATP-sensitive inward rectifier potassium channel 14 / Q9UNX9* / potassium voltage-gated channel subfamily J member 14*	ENSMUSG00000058743	40
Kcnj11 / Q61743 / ATP-sensitive inward rectifier potassium channel 11 / Q14654* / potassium voltage-gated channel subfamily J member 11*	ENSMUSG00000096146	40
Kcnj1 / O88335 / ATP-sensitive inward rectifier potassium channel 1 / P48048* / potassium voltage-gated channel subfamily J member 1*	ENSMUSG00000041248	35
Kcnj10 / Q9JM63 / ATP-sensitive inward rectifier potassium channel 10 / P78508* / potassium voltage-gated channel subfamily J member 10*	ENSMUSG00000044708	32
Kcnj15 / O88932 / ATP-sensitive inward rectifier potassium channel 15 / Q99712* / potassium voltage-gated channel subfamily J member 15*	ENSMUSG00000062609	29

Protein motifs (from Interpro)

Interpro ID	Name
IPR003275	Potassium channel, inwardly rectifying, Kir3.2
IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
IPR014756	Immunoglobulin E-set
IPR016449	Potassium channel, inwardly rectifying, Kir

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006813	potassium ion transport	IEA
biological_process	GO:0034220	ion transmembrane transport	IEA
biological_process	GO:0034765	regulation of ion transmembrane transport	IEA
biological_process	GO:0071805	potassium ion transmembrane transport	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0005242	inward rectifier potassium channel activity	IEA
molecular_function	GO:0005244	voltage-gated ion channel activity	IEA
molecular_function	GO:0015467	G-protein activated inward rectifier potassium channel activity	IEA

Pathways (from Reactome)

Pathway description

Activation of G protein gated Potassium channels

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6J Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6 * CBA/CaGnLe Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0000852	small cerebellum	"reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6 * CBA/CaGnLe
MP:0000854	abnormal cerebellum development	"malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0000864	abnormal vermis	"malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6J Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0000872	abnormal external granule cell layer	"malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe
MP:0000875	abnormal cerebellar Purkinje cell layer	"any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: B6CBACa A^w-J/A-Kcnj6^wv/J Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6J Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6 * CBA/CaGnLe Allelic Composition: Kcnj6^tm1Stf/Kcnj6^wv Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0000877	abnormal Purkinje cell	"any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Adra1a^tm1Pcs/Adra1a⁺ Genetic Background: involves: 129X1/SvJ * FVB/N Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6J
MP:0000879	increased Purkinje cell number	"greater than normal number of neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0000880	decreased Purkinje cell number	"fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Cav1^tm1Mls/Cav1^tm1Mls,Cav3^tm1Mls/Cav3^tm1Mls Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0000884	delaminated Purkinje cell layer	"splitting or disorganization of the layer of large neuron cell bodies between the molecular and granular layers of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: B6CBACa A^w-J/A-Kcnj6^wv/J
MP:0000885	ectopic Purkinje cell	"Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0000886	abnormal cerebellar granule layer	"any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6J Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6 * CBA/CaGnLe
MP:0000889	abnormal cerebellar molecular layer	"any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6J Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6
MP:0001154	seminiferous tubule degeneration	"a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe
MP:0001156	abnormal spermatogenesis	"incomplete maturation or aberrant formation of the male gametes" [J:58959]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: B6CBA A^w-J/A-Kcnj6^wv
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: B6CBACa A^w-J/A-Kcnj6^wv/J
MP:0001386	abnormal maternal nurturing	"failure of mothers to tend offspring" [J:39801]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0001392	abnormal locomotor activity	"altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nnt^G745D/Nnt^G745D Genetic Background: involves: BALB/c * C3H/HeH
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0001523	impaired righting response	"reduced ability or greater amount of time needed to recover from supine position" [J:25565]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe
MP:0001765	abnormal ion homeostasis	"anomaly in the state of equilibrium in the body with respect to charged molecules in the fluids and tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd2^tm1Dwo/Pkd2^tm1Dwo Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0002066	abnormal motor capabilities/coordination/movement	"altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: B6CBACa A^w-J/A-Kcnj6^wv/J
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd2^tm1Dwo/Pkd2^tm1Dwo Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0002204	abnormal neurotransmitter physiology	"aberrant function or production of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cav1^tm1Mls/Cav1^tm1Mls,Cav3^tm1Mls/Cav3^tm1Mls Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0002206	abnormal CNS synaptic transmission	"defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cav1^tm1Mls/Cav1^tm1Mls,Cav3^tm1Mls/Cav3^tm1Mls Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0002216	abnormal seminiferous tubule morphology	"malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe
MP:0002272	abnormal nervous system electrophysiology	"anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ncr1^m1J/Ncr1^m1J,Pepc^b/Pepc^b,Ptprc^a/Ptprc^a Genetic Background: B6.SJL-Ptprc^a Pepc^b/BoyJ
MP:0002573	behavioral despair	"depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]	Show Allelic Composition: Ncr1^m1J/Ncr1^m1J,Pepc^b/Pepc^b,Ptprc^a/Ptprc^a Genetic Background: B6.SJL-Ptprc^a Pepc^b/BoyJ
MP:0002631	abnormal epididymis morphology	"malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe
MP:0002674	abnormal sperm motility	"anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: B6CBA A^w-J/A-Kcnj6^wv
MP:0002686	globozoospermia	"malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: B6CBA A^w-J/A-Kcnj6^wv
MP:0002761	abnormal hippocampal mossy fiber morphology	"absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0002784	abnormal Sertoli cell morphology	"malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0002906	susceptibility to pharmacologically induced seizures	"inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]	Show Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Tg(Drd1a-cre)AGsc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0003091	abnormal cell migration	"defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6J Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0003313	abnormal locomotor activation	"altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0003635	abnormal synaptic transmission	"defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pkd2^tm1Dwo/Pkd2^tm1Dwo Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) Allelic Composition: Kcnj6^tm1Stf/Kcnj6^tm1Stf Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003964	abnormal noradrenaline level	"aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe
MP:0003997	tonic-clonic seizures	"increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^tm1Stf/Kcnj6^tm1Stf Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004097	abnormal cerebellar cortex morphology	"any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6J
MP:0004098	abnormal granule neuron	"any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6
MP:0004144	hypotonia	"decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe
MP:0004494	abnormal synaptic glutamate release	"aberrant secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6
MP:0005159	azoospermia	"absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe
MP:0005643	decreased dopamine level	"less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6J Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0006097	abnormal cerebellar lobule formation	"anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0006098	absent cerebellar lobules	"missing lobes of the cerebellum" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0006099	thin granule layer	"reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]	Show Allelic Composition: Kcnj6^tm1Stf/Kcnj6^wv Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0006362	abnormal male germ cell morphology	"any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: B6CBA A^w-J/A-Kcnj6^wv
MP:0006380	abnormal spermatid morphology	"anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: B6CBA A^w-J/A-Kcnj6^wv
MP:0008284	abnormal hippocampus pyramidal cell layer		Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0008572	abnormal Purkinje cell dendrite morphology	"any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: B6CBACa A^w-J/A-Kcnj6^wv/J
MP:0008911	induced hyperactivity	"increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0008913	listing	"momentary, slow motions of the whole body from side to side sometimes followed by a sudden drop from an erect position" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0009268	absent cerebellum fissure	"absence of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0009358	environmentally induced seizures	"relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnj6^tm1Stf/Kcnj6^tm1Stf Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010011	ectopic hippocampus pyramidal cells	"the hippocampus pyramidal cell body resides in places other than the pyramidal cell layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J
MP:0010323	retropulsion	"a tendency to step or walk backwards" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6 * CBA/CaGnLe
MP:0011084	partial lethality at weaning	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0011448	decreased dopaminergic neuron number	"fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0011750	abnormal seminiferous tubule epithelium morphology	"any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: B6CBA A^w-J/A-Kcnj6^wv
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: C57BL/6J-Kcnj6^wv
MP:0012490	abnormal cochlear VIII nucleus morphology	"any structural anomaly of two paired brainstem nuclei, the dorsal cochlear nucleus and the ventral cochlear nucleus, that lie dorsal and ventral, respectively, to the inferior cerebellar peduncle at the rostral pole of the medulla; the cochlear nuclei receive input from the cochlear nerve and send projections to the inferior colliculus, the medial geniculate, and other forebrain structures" [MGI:csmith]	Show Allelic Composition: Kcnj6^wv/Kcnj6^wv Genetic Background: involves: C57BL/6
MP:0013219	abnormal substantia nigra pars compacta morphology	"any structural anomaly of the posterior (dorsal) part of grey matter of the substantia nigra which contains large, polygonal, and densely packed dopamine-producing cells; pars compacta neurons are pigmented in many species" [MGI:anna]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J Allelic Composition: Kcnj6^wv/Kcnj6⁺ Genetic Background: involves: C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000023439	Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*	/ complex
ENSMUSG00000024462	Gabbr1 / Q9WV18 / Gamma-aminobutyric acid type B receptor subunit 1 / Q9UBS5*	/ complex
ENSMUSG00000029713	Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*	/ complex
ENSMUSG00000029064	Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*	/ complex
ENSMUSG00000026824	Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*	/ complex
ENSMUSG00000038026	Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9 / Q92806* / potassium voltage-gated channel subfamily J member 9*	/ complex
ENSMUSG00000043301	Kcnj6 / G protein-activated inward rectifier potassium channel 2 isoform Girk2B / P48051* / potassium voltage-gated channel subfamily J member 6*	/ complex
ENSMUSG00000032034	Kcnj5 / P48545 / G protein-activated inward rectifier potassium channel 4 / P48544* / potassium voltage-gated channel subfamily J member 5*	/ complex
ENSMUSG00000039809	Gabbr2 / Q80T41 / Gamma-aminobutyric acid type B receptor subunit 2 / O75899*	/ complex

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