MP:0000746 | weakness | "state of being infirm or less strong than littermates" [J:45400] |
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0000920 | abnormal myelination | "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0000951 | sporadic seizures | "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Adh1tm2Gdu/Adh1tm2Gdu,Adh7tm1Gdu/Adh7tm1Gdu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Adh1tm2Gdu/Adh1tm2Gdu,Adh7tm1Gdu/Adh7tm1Gdu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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MP:0001363 | increased anxiety-related response | "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060] |
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Allelic Composition: Grm1nmf373/Grm1nmf373 Genetic Background: C57BL/6J-Grm1nmf373/J
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MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+ Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0001429 | dehydration | "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053] |
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0001458 | abnormal object recognition memory | "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6ltm1Hta/Sez6ltm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta Genetic Background: involves: 129 * C57BL
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MP:0001473 | reduced long term potentiation | "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
Allelic Composition: Gabbr1tm3Bet/Gabbr1tm3Bet Genetic Background: BALB/c-Gabbr1tm3Bet
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MP:0001496 | audiogenic seizures | "a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Grm1nmf373/Grm1nmf373 Genetic Background: C57BL/6J-Grm1nmf373/J
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MP:0001501 | abnormal sleep pattern | "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Baxtm1Sjk/Bax+ Genetic Background: involves: 129X1/SvJ
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MP:0001504 | abnormal posture | "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984] |
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0001751 | increased circulating luteinizing hormone level | "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0001777 | abnormal body temperature regulation | "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hoxd13tm1Mrc/Hoxd13+ Genetic Background: involves: 129S7/SvEvBrd
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MP:0001923 | reduced female fertility | "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0001927 | abnormal oestrous cycle (sensu Rodentia) | "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
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Allelic Composition: Grm1nmf373/Grm1nmf373 Genetic Background: C57BL/6J-Grm1nmf373/J
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MP:0002064 | seizures | "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Grm1nmf373/Grm1nmf373 Genetic Background: C57BL/6J-Grm1nmf373/J
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0002206 | abnormal CNS synaptic transmission | "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Baxtm1Sjk/Bax+ Genetic Background: involves: 129X1/SvJ
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MP:0002272 | abnormal nervous system electrophysiology | "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
Allelic Composition: Gabbr1tm1Pngl/Gabbr1tm1Pngl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0002572 | abnormal emotion/affect behavior | "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0002651 | abnormal sciatic nerve | "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0002738 | hyperresponsive to tactile stimuli | "exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0002752 | abnormal somatic nervous system morphology | "malformation or absence of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0002805 | abnormal conditioned taste aversion behavior | "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Gabbr1tm3Bet/Gabbr1tm3Bet Genetic Background: BALB/c-Gabbr1tm3Bet
Allelic Composition: Gabbr1tm4Bet/Gabbr1tm4Bet Genetic Background: BALB/c-Gabbr1tm4Bet
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MP:0002910 | abnormal excitatory postsynaptic currents | "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
Allelic Composition: Gabbr1tm3Bet/Gabbr1tm3Bet Genetic Background: BALB/c-Gabbr1tm3Bet
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MP:0002911 | abnormal inhibitory postsynaptic potential | "defect in the membrane potential detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Gabbr1tm1Pngl/Gabbr1tm1Pngl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0002945 | abnormal inhibitory postsynaptic currents | "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
Allelic Composition: Gabbr1tm4Bet/Gabbr1tm4Bet Genetic Background: BALB/c-Gabbr1tm4Bet
Allelic Composition: Gabbr1tm2Bet/Gabbr1tm2Bet,Tg(HCRT-cre)1Stak/0 Genetic Background: involves: BALB/cA * C57BL/6 * DBA/1
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MP:0003216 | absence seizures | "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0003360 | depression-related behavior | |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0003635 | abnormal synaptic transmission | "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0003871 | abnormal myelin sheath morphology | "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0003996 | clonic seizures | "increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0003997 | tonic-clonic seizures | "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
Allelic Composition: Gabbr1tm1Pngl/Gabbr1tm1Pngl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0003998 | decreased thermal nociceptive threshold | "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0004000 | impaired passive avoidance behavior | "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
Allelic Composition: Gabbr1tm1Bet/Gabbr1+ Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0004811 | abnormal neuron physiology | "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Gabbr1tm2Bet/Gabbr1tm2Bet,Hdctm1.1(icre)Wwis/Hdc+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0005124 | increased circulating prolactin level | "greater than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0005402 | abnormal action potential | "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gabbr1tm1Pngl/Gabbr1tm1Pngl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0005498 | hyporesponsive to tactile stimuli | "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0006404 | abnormal lumbar dorsal root ganglion morphology | "any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the lumbar vertebrae" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0008843 | absent subcutaneous adipose tissue | "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0008874 | decreased sensitivity to xenobiotics | "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0009015 | short proestrus | "decrease in the length of the proestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0009017 | prolonged estrus | "increase in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0009141 | increased prepulse inhibition | "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gabbr1tm1Pngl/Gabbr1tm1Pngl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0009747 | impaired behavioral response to xenobiotic | "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gabbr1tm1Bet/Gabbr1tm1Bet Genetic Background: BALB/c-Gabbr1tm1Bet
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Gabbr1tm1Pngl/Gabbr1tm1Pngl Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Coq7tm1Hek/Coq7+ Genetic Background: B6.129-Coq7tm1Hek
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MP:0011620 | abnormal habituation to a new environment | "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment" [MGI:csmith] |
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Allelic Composition: Gabbr1tm2Bet/Gabbr1tm2Bet,Hdctm1.1(icre)Wwis/Hdc+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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