ENSG00000204681


Homo sapiens

Features
Gene ID: ENSG00000204681
  
Biological name :GABBR1
  
Synonyms : GABBR1 / gamma-aminobutyric acid type B receptor subunit 1 / Q9UBS5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p22.1
Gene start: 29555629
Gene end: 29633976
  
Corresponding Affymetrix probe sets: 203146_s_at (Human Genome U133 Plus 2.0 Array)   205890_s_at (Human Genome U133 Plus 2.0 Array)   238569_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419061
Ensembl peptide - ENSP00000417663
Ensembl peptide - ENSP00000419356
Ensembl peptide - ENSP00000420602
Ensembl peptide - ENSP00000419755
Ensembl peptide - ENSP00000348248
Ensembl peptide - ENSP00000366176
Ensembl peptide - ENSP00000366211
Ensembl peptide - ENSP00000366215
Ensembl peptide - ENSP00000366233
Ensembl peptide - ENSP00000417332
Ensembl peptide - ENSP00000417478
NCBI entrez gene - 2550     See in Manteia.
OMIM - 603540
RefSeq - XM_017010676
RefSeq - NM_001319053
RefSeq - NM_001470
RefSeq - NM_021903
RefSeq - NM_021904
RefSeq - XM_005248982
RefSeq - XM_006715047
RefSeq - XM_011514453
RefSeq - XM_011514455
RefSeq Peptide - NP_001461
RefSeq Peptide - NP_068703
RefSeq Peptide - NP_068704
RefSeq Peptide - NP_001305982
swissprot - F8WAS6
swissprot - F8WAV2
swissprot - F8WDC0
swissprot - F8WF38
swissprot - Q9UBS5
swissprot - Q5SUJ9
swissprot - A0A1U9X7R0
swissprot - C9JZG6
swissprot - C9J342
Ensembl - ENSG00000204681
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabbr1aENSDARG00000018967Danio rerio
 gabbr1bENSDARG00000016667Danio rerio
 Gabbr1ENSMUSG00000024462Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GABBR2 / O75899 / gamma-aminobutyric acid type B receptor subunit 2ENSG0000013692827
GPR156 / Q8NFN8 / G protein-coupled receptor 156ENSG000001756979


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR001828  Receptor, ligand binding region
 IPR002455  GPCR family 3, GABA-B receptor
 IPR002456  GPCR family 3, gamma-aminobutyric acid receptor, type B1
 IPR017978  GPCR family 3, C-terminal
 IPR028082  Periplasmic binding protein-like I
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity TAS
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0038037 G-protein coupled receptor dimeric complex IEA
 cellular_componentGO:0038039 G-protein coupled receptor heterodimeric complex IPI
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004965 G-protein coupled GABA receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
GABA B receptor activation
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111664 GNB3 / P16520 / G protein subunit beta 3  / complex
 ENSG00000123700 KCNJ2 / P63252 / potassium voltage-gated channel subfamily J member 2  / complex
 ENSG00000136928 GABBR2 / O75899 / gamma-aminobutyric acid type B receptor subunit 2  / complex
 ENSG00000162989 KCNJ3 / P48549 / potassium voltage-gated channel subfamily J member 3  / complex
 ENSG00000153822 KCNJ16 / Q9NPI9 / potassium voltage-gated channel subfamily J member 16  / complex
 ENSG00000172354 GNB2 / P62879 / G protein subunit beta 2  / complex
 ENSG00000168135 KCNJ4 / P48050 / potassium voltage-gated channel subfamily J member 4  / complex
 ENSG00000157551 KCNJ15 / Q99712 / potassium voltage-gated channel subfamily J member 15  / complex
 ENSG00000120457 KCNJ5 / P48544 / potassium voltage-gated channel subfamily J member 5  / complex
 ENSG00000184185 KCNJ12 / Q14500 / potassium voltage-gated channel subfamily J member 12  / complex
 ENSG00000162728 KCNJ9 / Q92806 / potassium voltage-gated channel subfamily J member 9  / complex
 ENSG00000177807 KCNJ10 / P78508 / potassium voltage-gated channel subfamily J member 10  / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex
 ENSG00000157542 KCNJ6 / P48051 / potassium voltage-gated channel subfamily J member 6  / complex






 

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