ENSG00000162989


Homo sapiens

Features
Gene ID: ENSG00000162989
  
Biological name :KCNJ3
  
Synonyms : KCNJ3 / P48549 / potassium voltage-gated channel subfamily J member 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q24.1
Gene start: 154698299
Gene end: 154858352
  
Corresponding Affymetrix probe sets: 207141_s_at (Human Genome U133 Plus 2.0 Array)   207142_at (Human Genome U133 Plus 2.0 Array)   233059_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295101
Ensembl peptide - ENSP00000438410
NCBI entrez gene - 3760     See in Manteia.
OMIM - 601534
RefSeq - NM_001260509
RefSeq - NM_001260508
RefSeq - NM_002239
RefSeq Peptide - NP_001247437
RefSeq Peptide - NP_001247438
RefSeq Peptide - NP_002230
swissprot - P48549
Ensembl - ENSG00000162989
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnj3aENSDARG00000077165Danio rerio
 kcnj3bENSDARG00000062217Danio rerio
 KCNJ3ENSGALG00000012537Gallus gallus
 Kcnj3ENSMUSG00000026824Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNJ5 / P48544 / potassium voltage-gated channel subfamily J member 5ENSG0000012045746
KCNJ6 / P48051 / potassium voltage-gated channel subfamily J member 6ENSG0000015754245
KCNJ9 / Q92806 / potassium voltage-gated channel subfamily J member 9ENSG0000016272844
KCNJ2 / P63252 / potassium voltage-gated channel subfamily J member 2ENSG0000012370038
KCNJ12 / Q14500 / potassium voltage-gated channel subfamily J member 12ENSG0000018418538
B7U540 / KCNJ18 / potassium voltage-gated channel subfamily J member 18ENSG0000026045837
KCNJ4 / P48050 / potassium voltage-gated channel subfamily J member 4ENSG0000016813537
KCNJ14 / Q9UNX9 / potassium voltage-gated channel subfamily J member 14ENSG0000018232434
KCNJ11 / Q14654 / potassium voltage-gated channel subfamily J member 11ENSG0000018748633
KCNJ8 / Q15842 / potassium voltage-gated channel subfamily J member 8ENSG0000012136133
KCNJ1 / P48048 / potassium voltage-gated channel subfamily J member 1ENSG0000015170430
KCNJ10 / P78508 / potassium voltage-gated channel subfamily J member 10ENSG0000017780728
KCNJ15 / Q99712 / potassium voltage-gated channel subfamily J member 15ENSG0000015755125


Protein motifs (from Interpro)
Interpro ID Name
 IPR003274  Potassium channel, inwardly rectifying, Kir3.1
 IPR013518  Potassium channel, inwardly rectifying, Kir, cytoplasmic
 IPR014756  Immunoglobulin E-set
 IPR016449  Potassium channel, inwardly rectifying, Kir


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport TAS
 biological_processGO:0010107 potassium ion import IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IC
 biological_processGO:0098914 membrane repolarization during atrial cardiac muscle cell action potential IC
 biological_processGO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential IEA
 biological_processGO:0099625 ventricular cardiac muscle cell membrane repolarization IC
 biological_processGO:1990573 potassium ion import across plasma membrane IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008076 voltage-gated potassium channel complex IDA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030315 T-tubule IEA
 molecular_functionGO:0005242 inward rectifier potassium channel activity IDA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015467 G-protein activated inward rectifier potassium channel activity TAS
 molecular_functionGO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization IC
 molecular_functionGO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IC


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex
 ENSG00000136928 GABBR2 / O75899 / gamma-aminobutyric acid type B receptor subunit 2  / complex
 ENSG00000172354 GNB2 / P62879 / G protein subunit beta 2  / complex
 ENSG00000111664 GNB3 / P16520 / G protein subunit beta 3  / complex
 ENSG00000162989 KCNJ3 / P48549 / potassium voltage-gated channel subfamily J member 3  / complex
 ENSG00000157542 KCNJ6 / P48051 / potassium voltage-gated channel subfamily J member 6  / complex
 ENSG00000204681 GABBR1 / Q9UBS5 / gamma-aminobutyric acid type B receptor subunit 1  / complex
 ENSG00000120457 KCNJ5 / P48544 / potassium voltage-gated channel subfamily J member 5  / complex
 ENSG00000162728 KCNJ9 / Q92806 / potassium voltage-gated channel subfamily J member 9  / complex






 

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