ENSG00000168135


Homo sapiens

Features
Gene ID: ENSG00000168135
  
Biological name :KCNJ4
  
Synonyms : KCNJ4 / P48050 / potassium voltage-gated channel subfamily J member 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q13.1
Gene start: 38426327
Gene end: 38455199
  
Corresponding Affymetrix probe sets: 208359_s_at (Human Genome U133 Plus 2.0 Array)   211451_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000306497
NCBI entrez gene - 3761     See in Manteia.
OMIM - 600504
RefSeq - NM_004981
RefSeq - NM_152868
RefSeq Peptide - NP_004972
RefSeq Peptide - NP_690607
swissprot - P48050
swissprot - A0A024R1L8
Ensembl - ENSG00000168135
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01079818.1ENSDARG00000068110Danio rerio
 KCNJ4ENSGALG00000012254Gallus gallus
 Kcnj4ENSMUSG00000044216Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNJ12 / Q14500 / potassium voltage-gated channel subfamily J member 12ENSG0000018418563
B7U540 / KCNJ18 / potassium voltage-gated channel subfamily J member 18ENSG0000026045863
KCNJ2 / P63252 / potassium voltage-gated channel subfamily J member 2ENSG0000012370060
KCNJ14 / Q9UNX9 / potassium voltage-gated channel subfamily J member 14ENSG0000018232452
KCNJ9 / Q92806 / potassium voltage-gated channel subfamily J member 9ENSG0000016272843
KCNJ5 / P48544 / potassium voltage-gated channel subfamily J member 5ENSG0000012045742
KCNJ6 / P48051 / potassium voltage-gated channel subfamily J member 6ENSG0000015754242
KCNJ3 / P48549 / potassium voltage-gated channel subfamily J member 3ENSG0000016298941
KCNJ11 / Q14654 / potassium voltage-gated channel subfamily J member 11ENSG0000018748638
KCNJ8 / Q15842 / potassium voltage-gated channel subfamily J member 8ENSG0000012136138
KCNJ1 / P48048 / potassium voltage-gated channel subfamily J member 1ENSG0000015170436
KCNJ10 / P78508 / potassium voltage-gated channel subfamily J member 10ENSG0000017780732
KCNJ15 / Q99712 / potassium voltage-gated channel subfamily J member 15ENSG0000015755131


Protein motifs (from Interpro)
Interpro ID Name
 IPR003273  Potassium channel, inwardly rectifying, Kir2.3
 IPR013518  Potassium channel, inwardly rectifying, Kir, cytoplasmic
 IPR014756  Immunoglobulin E-set
 IPR016449  Potassium channel, inwardly rectifying, Kir


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport TAS
 biological_processGO:0010107 potassium ion import IBA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0061337 cardiac conduction TAS
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008076 voltage-gated potassium channel complex TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005242 inward rectifier potassium channel activity TAS
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015467 G-protein activated inward rectifier potassium channel activity TAS
 molecular_functionGO:0030165 PDZ domain binding IPI


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Classical Kir channels
Phase 4 - resting membrane potential
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123700 KCNJ2 / P63252 / potassium voltage-gated channel subfamily J member 2  / complex
 ENSG00000136928 GABBR2 / O75899 / gamma-aminobutyric acid type B receptor subunit 2  / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex
 ENSG00000182324 KCNJ14 / Q9UNX9 / potassium voltage-gated channel subfamily J member 14  / complex
 ENSG00000111664 GNB3 / P16520 / G protein subunit beta 3  / complex
 ENSG00000168135 KCNJ4 / P48050 / potassium voltage-gated channel subfamily J member 4  / complex
 ENSG00000172354 GNB2 / P62879 / G protein subunit beta 2  / complex
 ENSG00000204681 GABBR1 / Q9UBS5 / gamma-aminobutyric acid type B receptor subunit 1  / complex
 ENSG00000153822 KCNJ16 / Q9NPI9 / potassium voltage-gated channel subfamily J member 16  / complex
 ENSG00000177807 KCNJ10 / P78508 / potassium voltage-gated channel subfamily J member 10  / complex
 ENSG00000184185 KCNJ12 / Q14500 / potassium voltage-gated channel subfamily J member 12  / complex






 

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