ENSG00000184185


Homo sapiens

Features
Gene ID: ENSG00000184185
  
Biological name :KCNJ12
  
Synonyms : KCNJ12 / potassium voltage-gated channel subfamily J member 12 / Q14500
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p11.2
Gene start: 21376197
Gene end: 21419872
  
Corresponding Affymetrix probe sets: 207110_at (Human Genome U133 Plus 2.0 Array)   208567_s_at (Human Genome U133 Plus 2.0 Array)   232289_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000328150
Ensembl peptide - ENSP00000463778
NCBI entrez gene - 3768     See in Manteia.
OMIM - 602323
RefSeq - XM_011523831
RefSeq - NM_021012
RefSeq - XM_005256625
RefSeq Peptide - NP_066292
swissprot - Q14500
Ensembl - ENSG00000184185
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnj12aENSDARG00000104965Danio rerio
 F1NHE9ENSGALG00000004721Gallus gallus
 Kcnj12ENSMUSG00000042529Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B7U540 / KCNJ18 / potassium voltage-gated channel subfamily J member 18ENSG0000026045899
KCNJ2 / P63252 / potassium voltage-gated channel subfamily J member 2ENSG0000012370070
KCNJ4 / P48050 / potassium voltage-gated channel subfamily J member 4ENSG0000016813565
KCNJ14 / Q9UNX9 / potassium voltage-gated channel subfamily J member 14ENSG0000018232456
KCNJ9 / Q92806 / potassium voltage-gated channel subfamily J member 9ENSG0000016272845
KCNJ5 / P48544 / potassium voltage-gated channel subfamily J member 5ENSG0000012045744
KCNJ3 / P48549 / potassium voltage-gated channel subfamily J member 3ENSG0000016298943
KCNJ6 / P48051 / potassium voltage-gated channel subfamily J member 6ENSG0000015754243
KCNJ8 / Q15842 / potassium voltage-gated channel subfamily J member 8ENSG0000012136140
KCNJ11 / Q14654 / potassium voltage-gated channel subfamily J member 11ENSG0000018748640
KCNJ1 / P48048 / potassium voltage-gated channel subfamily J member 1ENSG0000015170437
KCNJ10 / P78508 / potassium voltage-gated channel subfamily J member 10ENSG0000017780734
KCNJ15 / Q99712 / potassium voltage-gated channel subfamily J member 15ENSG0000015755133


Protein motifs (from Interpro)
Interpro ID Name
 IPR003272  Potassium channel, inwardly rectifying, Kir2.2
 IPR013518  Potassium channel, inwardly rectifying, Kir, cytoplasmic
 IPR013673  Potassium channel, inwardly rectifying, Kir, N-terminal
 IPR014756  Immunoglobulin E-set
 IPR016449  Potassium channel, inwardly rectifying, Kir


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IDA
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0008016 regulation of heart contraction TAS
 biological_processGO:0010107 potassium ion import IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:0061337 cardiac conduction TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031224 intrinsic component of membrane IDA
 molecular_functionGO:0005242 inward rectifier potassium channel activity IDA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0015467 G-protein activated inward rectifier potassium channel activity TAS


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
Classical Kir channels
Phase 4 - resting membrane potential
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123700 KCNJ2 / P63252 / potassium voltage-gated channel subfamily J member 2  / complex
 ENSG00000168135 KCNJ4 / P48050 / potassium voltage-gated channel subfamily J member 4  / complex
 ENSG00000182324 KCNJ14 / Q9UNX9 / potassium voltage-gated channel subfamily J member 14  / complex
 ENSG00000184185 KCNJ12 / Q14500 / potassium voltage-gated channel subfamily J member 12  / complex
 ENSG00000111664 GNB3 / P16520 / G protein subunit beta 3  / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex
 ENSG00000172354 GNB2 / P62879 / G protein subunit beta 2  / complex
 ENSG00000204681 GABBR1 / Q9UBS5 / gamma-aminobutyric acid type B receptor subunit 1  / complex
 ENSG00000153822 KCNJ16 / Q9NPI9 / potassium voltage-gated channel subfamily J member 16  / complex
 ENSG00000136928 GABBR2 / O75899 / gamma-aminobutyric acid type B receptor subunit 2  / complex
 ENSG00000177807 KCNJ10 / P78508 / potassium voltage-gated channel subfamily J member 10  / complex






 

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