Manteia - Molecule gene

ENSMUSG00000038026

Mus musculus

Features

Gene ID:	ENSMUSG00000038026

Biological name :	Kcnj9

Synonyms :	Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9

Possible biological names infered from orthology :	potassium voltage-gated channel subfamily J member 9 / Q92806

Species:	Mus musculus

Chr. number:	1
Strand:	-1
Band:	H3
Gene start:	172320501
Gene end:	172329318

Corresponding Affymetrix probe sets:	10360297 (MoGene1.0st) 1426115_a_at (Mouse Genome 430 2.0 Array) 1428602_at (Mouse Genome 430 2.0 Array) 1433029_at (Mouse Genome 430 2.0 Array) 1450712_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000060110 Ensembl peptide - ENSMUSP00000141633 NCBI entrez gene - 16524 See in Manteia. MGI - MGI:108007 RefSeq - XM_006496678 RefSeq - NM_008429 RefSeq Peptide - NP_032455 swissprot - P48543 swissprot - Q544N3 Ensembl - ENSMUSG00000038026

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
kcnj9	ENSDARG00000061636	Danio rerio
KCNJ9	ENSG00000162728	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kcnj6 / G protein-activated inward rectifier potassium channel 2 isoform Girk2B / P48051* / potassium voltage-gated channel subfamily J member 6*	ENSMUSG00000043301	69
Kcnj5 / P48545 / G protein-activated inward rectifier potassium channel 4 / P48544* / potassium voltage-gated channel subfamily J member 5*	ENSMUSG00000032034	65
Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*	ENSMUSG00000026824	56
Kcnj12 / P52187 / ATP-sensitive inward rectifier potassium channel 12 / Q14500* / potassium voltage-gated channel subfamily J member 12*	ENSMUSG00000042529	50
Kcnj2 / P35561 / potassium inwardly-rectifying channel, subfamily J, member 2 / P63252* / potassium voltage-gated channel subfamily J member 2*	ENSMUSG00000041695	48
Kcnj4 / potassium voltage-gated channel subfamily J member 4 / P48050*	ENSMUSG00000044216	48
Kcnj14 / Q8JZN3 / ATP-sensitive inward rectifier potassium channel 14 / Q9UNX9* / potassium voltage-gated channel subfamily J member 14*	ENSMUSG00000058743	47
Kcnj11 / Q61743 / ATP-sensitive inward rectifier potassium channel 11 / Q14654* / potassium voltage-gated channel subfamily J member 11*	ENSMUSG00000096146	42
Kcnj8 / P97794 / potassium inwardly-rectifying channel, subfamily J, member 8 / Q15842* / potassium voltage-gated channel subfamily J member 8*	ENSMUSG00000030247	41
Kcnj1 / O88335 / ATP-sensitive inward rectifier potassium channel 1 / P48048* / potassium voltage-gated channel subfamily J member 1*	ENSMUSG00000041248	38
Kcnj10 / Q9JM63 / ATP-sensitive inward rectifier potassium channel 10 / P78508* / potassium voltage-gated channel subfamily J member 10*	ENSMUSG00000044708	36
Kcnj15 / O88932 / ATP-sensitive inward rectifier potassium channel 15 / Q99712* / potassium voltage-gated channel subfamily J member 15*	ENSMUSG00000062609	30

Protein motifs (from Interpro)

Interpro ID	Name
IPR003276	Potassium channel, inwardly rectifying, Kir3.3
IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
IPR014756	Immunoglobulin E-set
IPR016449	Potassium channel, inwardly rectifying, Kir

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006813	potassium ion transport	IEA
biological_process	GO:0010107	potassium ion import	IBA
biological_process	GO:0034220	ion transmembrane transport	IEA
biological_process	GO:0034765	regulation of ion transmembrane transport	IEA
biological_process	GO:0071805	potassium ion transmembrane transport	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0005242	inward rectifier potassium channel activity	IBA
molecular_function	GO:0005244	voltage-gated ion channel activity	IEA
molecular_function	GO:0015467	G-protein activated inward rectifier potassium channel activity	IEA

Pathways (from Reactome)

Pathway description

Activation of G protein gated Potassium channels

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd2^tm1Dwo/Pkd2^tm1Dwo Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd2^tm1Dwo/Pkd2^tm1Dwo Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0003635	abnormal synaptic transmission	"defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pkd2^tm1Dwo/Pkd2^tm1Dwo Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) Allelic Composition: Kcnj6^tm1Stf/Kcnj6^tm1Stf,Kcnj9^tm1Kwn/Kcnj9^tm1Kwn Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000023439	Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*	/ complex
ENSMUSG00000024462	Gabbr1 / Q9WV18 / Gamma-aminobutyric acid type B receptor subunit 1 / Q9UBS5*	/ complex
ENSMUSG00000029713	Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*	/ complex
ENSMUSG00000029064	Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*	/ complex
ENSMUSG00000038026	Kcnj9 / P48543 / potassium inwardly-rectifying channel, subfamily J, member 9 / Q92806* / potassium voltage-gated channel subfamily J member 9*	/ complex
ENSMUSG00000032034	Kcnj5 / P48545 / G protein-activated inward rectifier potassium channel 4 / P48544* / potassium voltage-gated channel subfamily J member 5*	/ complex
ENSMUSG00000026824	Kcnj3 / P63250 / G protein-activated inward rectifier potassium channel 1 / P48549* / potassium voltage-gated channel subfamily J member 3*	/ complex
ENSMUSG00000043301	Kcnj6 / G protein-activated inward rectifier potassium channel 2 isoform Girk2B / P48051* / potassium voltage-gated channel subfamily J member 6*	/ complex
ENSMUSG00000039809	Gabbr2 / Q80T41 / Gamma-aminobutyric acid type B receptor subunit 2 / O75899*	/ complex

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr