Manteia - Molecule gene

ENSMUSG00000025127

Mus musculus

Features

Gene ID:	ENSMUSG00000025127

Biological name :	Gcgr

Synonyms :	Gcgr / Glucagon receptor / Q61606

Possible biological names infered from orthology :	P47871

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	E2
Gene start:	120530699
Gene end:	120538986

Corresponding Affymetrix probe sets:	10383409 (MoGene1.0st) 1450127_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000026119 NCBI entrez gene - 14527 See in Manteia. MGI - MGI:99572 RefSeq - XM_017314269 RefSeq - NM_008101 RefSeq - XM_017314267 RefSeq - XM_017314268 RefSeq - XM_006532216 RefSeq - XM_006532217 RefSeq - XM_017314263 RefSeq - XM_017314264 RefSeq - XM_017314265 RefSeq - XM_017314266 RefSeq Peptide - NP_032127 swissprot - Q61606 Ensembl - ENSMUSG00000025127

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gcgra	ENSDARG00000104022	Danio rerio
gcgrb	ENSDARG00000036272	Danio rerio
GCGR	ENSGALG00000011219	Gallus gallus
GCGR	ENSG00000215644	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gipr / Q0P543 / Gastric inhibitory polypeptide receptor / P48546*	ENSMUSG00000030406	46
Glp1r / O35659 / Glucagon-like peptide 1 receptor / P43220*	ENSMUSG00000024027	44
Glp2r / Q5IXF8 / Glucagon-like peptide 2 receptor / O95838*	ENSMUSG00000049928	40
P70205 / Adcyap1r1 / adenylate cyclase activating polypeptide 1 receptor 1 / P41586* / ADCYAP receptor type I*	ENSMUSG00000029778	33
Sctr / Q5FWI2 / Secretin receptor / P47872*	ENSMUSG00000026387	33
Vipr1 / P97751 / vasoactive intestinal peptide receptor 1 / P32241*	ENSMUSG00000032528	33
Pth1r / P41593 / Parathyroid hormone/parathyroid hormone-related peptide receptor / Q03431* / parathyroid hormone 1 receptor*	ENSMUSG00000032492	31
Vipr2 / P41588 / vasoactive intestinal peptide receptor 2 / P41587*	ENSMUSG00000011171	31
Pth2r / Q91V95 / Parathyroid hormone 2 receptor / P49190*	ENSMUSG00000025946	28
Ghrhr / P32082 / Growth hormone-releasing hormone receptor / Q02643*	ENSMUSG00000004654	28

Protein motifs (from Interpro)

Interpro ID	Name
IPR000832	GPCR, family 2, secretin-like
IPR001879	GPCR, family 2, extracellular hormone receptor domain
IPR003290	GPCR, family 2, glucagon-like peptide-1/glucagon receptor
IPR003291	GPCR, family 2, glucagon receptor
IPR017981	GPCR, family 2-like
IPR017983	GPCR, family 2, secretin-like, conserved site
IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006887	exocytosis	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007166	cell surface receptor signaling pathway	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0009755	hormone-mediated signaling pathway	IEA
biological_process	GO:0042593	glucose homeostasis	IMP
biological_process	GO:0042594	response to starvation	IMP
biological_process	GO:0070873	regulation of glycogen metabolic process	IMP
biological_process	GO:0071377	cellular response to glucagon stimulus	IDA
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0004967	glucagon receptor activity	IDA
molecular_function	GO:0017046	peptide hormone binding	IEA

Pathways (from Reactome)

Pathway description

Glucagon signaling in metabolic regulation

G alpha (q) signalling events

G alpha (s) signalling events

Glucagon-type ligand receptors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000182	increased circulating LDL cholesterol level	"greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1 Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch,Slc38a5^{tm1(KOMP)Vlcg}/Slc38a5^{tm1(KOMP)Vlcg} Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * C57BL/6NTac * SJL
MP:0001261	obese	"excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch,Lepr^tm1Jke/Lepr^tm1Jke Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL
MP:0001780	decreased brown fat amount	"reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lhx4^tm1Ssp/Lhx4^tm1Ssp Genetic Background: involves: 129S2/SvPas * CF1
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hipk1^tm1Hko/Hipk1^tm1Hko,Hipk2^tm1Hko/Hipk2^tm1Hko,Trp53^tm2Mok/Trp53⁺ Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002310	resistance to fatty liver development	"less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002710	increased glucagon secretion	"greater than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL
MP:0002712	increased circulating glucagon level	"greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch,Slc38a5^{tm1(KOMP)Vlcg}/Slc38a5^{tm1(KOMP)Vlcg} Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * C57BL/6NTac * SJL
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch,Slc38a5^{tm1(KOMP)Vlcg}/Slc38a5^{tm1(KOMP)Vlcg} Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * C57BL/6NTac * SJL
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL
MP:0003365	glucagonoma	"a pancreatic islet alpha cell adenoma that secretes excess glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003450	enlarged pancreas	"increase of the size of the pancreas compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004789	increased bile salt level	"increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL
MP:0005215	abnormal islet of Langerhans morphology	"anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005216	abnormal pancreatic alpha cell morphology	"malformation of the cells of the pancreas that secrete glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch,Slc38a5^{tm1(KOMP)Vlcg}/Slc38a5^{tm1(KOMP)Vlcg} Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * C57BL/6NTac * SJL
MP:0005290	decreased oxygen consumption	"less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL
MP:0005311	abnormal circulating amino acid level	"aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch,Slc38a5^{tm1(KOMP)Vlcg}/Slc38a5^{tm1(KOMP)Vlcg} Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * C57BL/6NTac * SJL
MP:0005318	decreased triglyceride level	"lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0005491	islet cell hyperplasia	"increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch,Slc38a5^{tm1(KOMP)Vlcg}/Slc38a5^{tm1(KOMP)Vlcg} Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * C57BL/6NTac * SJL
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL
MP:0005659	resistance to diet-induced obesity	"less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL
MP:0005668	decreased circulating leptin level	"less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0006087	increased body mass index	"greater than normal average of a measure of weight for height" [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008853	decreased abdominal adipose tissue amount	"reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008964	decreased carbon dioxide production	"reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL
MP:0009108	increased pancreas weight	"increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL
MP:0009113	increased pancreatic beta cell mass	"greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL
MP:0009146	abnormal pancreatic acinar cell morphology	"any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009153	pancreas tumor	"tumors or cancer of the pancreas" [MESH:C04.588.274.761]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009171	enlarged pancreatic islets	"increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009176	increased pancreatic alpha cell number	"increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL
MP:0009179	abnormal pancreatic alpha cell differentiation	"atypical production of or inability to produce the cells of the pancreas that secrete glucagon, and/or accumulation of pancreatic alpha cell precursors" [MESH:A03.734.414.065]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009283	decreased gonadal fat pad weight	"less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0009295	decreased interscapular fat pad weight		Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch,Lepr^tm1Jke/Lepr^tm1Jke Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0010182	decreased susceptibility to weight gain	"smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129/Sv * C57BL/6J * SJL
MP:0011819	increased pancreatic beta cell proliferation	"increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL
MP:0013558	abnormal exocrine gland morphology	"any structural anomaly of any of the glands of the exocrine system that secrete their essential product by way of a duct to some environment external to itself, either inside the body or on a surface of the body; the duct portion may be branched (compound) or unbranched (simple); the glandular portion may be tubular or acinar, or may be a mix of the two (tubuloacinar or tubuloalveolar); if the glandular portion branches, then the gland is called a branched gland Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas" [http://en.wikipedia.org/wiki/Exocrine_gland, MGI:Anna]	Show Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0014109	increased pancreatic alpha cell proliferation	"increase in the ability of the glucagon-producing cells of the islets of Langerhans in the endocrine pancreas to undergo expansion by cell division" [MGI:Anna]	Show Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * DBA * SJL Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL
MP:0020090	decreased susceptibility to diet-induced non-insulin dependent diabetes	"decreased likelihood to develop diet-induced non-insulin-dependent diabetes" [GOC:NV]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL
MP:0030589	increased pancreatic alpha cell mass	"greater total physical bulk or volume of a pancreatic alpha cell compared to the normal state" [MGI:anna]	Show Allelic Composition: Gcgr^tm1Mjch/Gcgr^tm1Mjch Genetic Background: involves: 129 * C57BL/6J * SJL

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000027523	Gnas / Q9Z0F1 / P63094 / Q6R0H6 / Q6R0H7 / GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus / P84996* / Q5JWF2* / O95467* / P63092* / GNAS complex locus*	/ reaction
ENSMUSG00000023439	Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*	/ reaction
ENSMUSG00000029064	Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*	/ reaction
ENSMUSG00000029713	Gnb2 / P62880 / guanine nucleotide binding protein (G protein), beta 2 / P62879* / G protein subunit beta 2*	/ reaction
ENSMUSG00000027669	Gnb4 / P29387 / guanine nucleotide binding protein (G protein), beta 4 / Q9HAV0* / G protein subunit beta 4*	/ reaction
ENSMUSG00000000394	Gcg / P55095 / Glucagon Glicentin Glicentin-related polypeptide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like pepti...	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr