ENSDARG00000036272


Danio rerio

Features
Gene ID: ENSDARG00000036272
  
Biological name :gcgrb
  
Synonyms : gcgrb / glucagon receptor b
  
Possible biological names infered from orthology : GCGR / glucagon receptor / P47871 / Q61606
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 56344651
Gene end: 56363108
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000013211
NCBI entrez gene - 565237     See in Manteia.
swissprot - F1RCQ6
ZFIN ID - ZDB-GENE-050516-2
Ensembl - ENSDARG00000036272
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GCGRENSGALG00000011219Gallus gallus
 GCGRENSG00000215644Homo sapiens
 GcgrENSMUSG00000025127Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gcgra / glucagon receptor a / GCGR* / P47871* / glucagon receptor*ENSDARG0000010402261
gipr / gastric inhibitory polypeptide receptor / P48546* / Q0P543*ENSDARG0000002547848
pth1ra / parathyroid hormone 1 receptor a / PTH1R* / Q03431* / P41593* / parathyroid hormone 1 receptor* / Parathyroid hormone/parathyroid hormone-related peptide receptor *ENSDARG0000002095731
vipr2 / vasoactive intestinal peptide receptor 2 / P41587* / P41588*ENSDARG0000001235331
adcyap1r1a / adcyap1r1b / adenylate cyclase activating polypeptide 1b (pituitary) receptor type I / P70205* / P41586* / ADCYAP1R1* / ADCYAP receptor type I* / adenylate cyclase activating p...ENSDARG0000005372430
vipr1a / vasoactive intestinal peptide receptor 1a / VIPR1* / P32241* / P97751* / vasoactive intestinal peptide receptor 1*ENSDARG0000002887830
si:dkeyp-4h4.1 / PTH2R* / P49190* / Q91V95* / parathyroid hormone 2 receptor*ENSDARG0000002118629
vipr1b / vasoactive intestinal peptide receptor 1b / VIPR1* / P32241* / P97751* / vasoactive intestinal peptide receptor 1*ENSDARG0000005905829
pth2r / parathyroid hormone 2 receptor / P49190* / Q91V95*ENSDARG0000000667828
pth1rb / parathyroid hormone 1 receptor bENSDARG0000001841828
ghrhra / growth hormone releasing hormone receptor a / GHRHR* / Q02643* / P32082* / growth hormone releasing hormone receptor*ENSDARG0000010496128
ghrhrb / growth hormone releasing hormone receptor b / GHRHR* / Q02643* / P32082* / growth hormone releasing hormone receptor*ENSDARG0000005370827
ghrhr2 / growth hormone releasing hormone receptor 2 / GHRHR* / Q02643* / P32082* / growth hormone releasing hormone receptor*ENSDARG0000009921827
SCTR / secretin receptor / P47872*ENSDARG0000010107725
adcyap1r1a / adenylate cyclase activating polypeptide 1a (pituitary) receptor type I / P70205* / P41586* / ADCYAP1R1* / ADCYAP receptor type I* / adenylate cyclase activating polypeptide 1 ...ENSDARG0000010520123


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001749  GPCR, family 2, gastric inhibitory polypeptide receptor
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0010906 regulation of glucose metabolic process IMP
 biological_processGO:0038192 gastric inhibitory peptide signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0016519 gastric inhibitory peptide receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IPI


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
G alpha (q) signalling events
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000140 pancreas pancreas has extra parts of type pancreatic A cell , abnormal
pancreas has extra parts of type pancreatic A cell , ameliorated
Show

 ZFA:0001094 whole organism whole organism decreased amount , abnormal
whole organism increased amount , abnormal
Show

 ZFA:0005754 primary islet primary islet pancreatic A cell increased amount , abnormal
Show

 ZFA:0009104 pancreatic A cell pancreatic A cell hyperplastic , abnormal
pancreatic A cell cell proliferation increased rate , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000040907 gcgb / glucagon b / GCG* / P01275* / P55095* / glucagon* / Glucagon Glicentin Glicentin-related polypeptide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Gluc...  / complex / reaction
 ENSDARG00000079296 gcga / glucagon a / GCG* / P01275* / P55095* / glucagon* / Glucagon Glicentin Glicentin-related polypeptide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Gluc...  / complex / reaction






 

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